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Compare Simbrinza vs. Combigan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Simbrinza (brinzolamide / brimonidine)
    Combigan (brimonidine / timolol)
  • Simbrinza (brinzolamide / brimonidine)
    Combigan (brimonidine / timolol)

  • Summary of Simbrinza vs. Combigan

    Summary for Carbonic anhydrase inhibitor / Alpha agonist
    Prescription only

    Simbrinza is a combination eye drop containing two medications: brinzolamide (a carbonic anhydrase inhibitor) and brimonidine (an alpha-2 agonist). It's used to treat glaucoma and high pressure in the eye. The dosage for the eye drops is placed 1 drop placed directly into the eye(s) three times per day to lower the pressure in the eye. Simbrinza is not yet available as a lower-cost generic. Side effects include eye irritation, blurry vision, and changes in taste.

    Summary for Alpha agonist / Beta blocker
    Prescription only

    Combigan is a combination eye drop containing brimonidine (an alpha agonist) and timolol (a beta blocker). It's used to lower high pressure inside the eye in adults with conditions like glaucoma or ocular hypertension. Typically, you apply one drop to the affected eye(s) twice daily, about 12 hours apart. Common side effects include eye redness, itching, or dryness. Combigan (brimonidine / timolol) is available as both a brand-name and generic medication.

  • Indications of Simbrinza vs. Combigan

    Indications for

    Treatment of high pressure in the eye in people ages 2 years and older with:

    •Ocular hypertension
    •Open-angle glaucoma
    Indications for

    Treatment of high pressure in the eye in people ages 2 years and older with:

    •Ocular hypertension
    •Open-angle glaucoma

  • Pros and Cons of Simbrinza vs. Combigan

    Pros and Const for Carbonic anhydrase inhibitor / Alpha agonist
    Pros
    •Works well to lower eye pressure
    •Conveniently combines two medications into one eye drop
    •Can use in children as young as 2 years old
    Cons
    •Must use three times a day
    •Might not be safe if you're allergic to sulfa medications
    •Not available as a lower-cost generic
    Pros and Const for Alpha agonist / Beta blocker
    Pros
    •Convenient to have a single eye drop that combines two different medications
    •Can be stored at room temperature
    •Possible option for children older than 2 years old
    Cons
    •Used twice a day
    •Can cause tiredness or drowsiness in some people
    •Not for people with asthma, severe chronic obstructive pulmonary disease (COPD), or certain heart-related problems

  • Common Side Effects of Simbrinza vs. Combigan

    Common Side Effects for

    Reported in up to 5% of people:

    •Blurry vision
    •Eye irritation
    •Changes in taste (e.g., bad taste in mouth)
    •Dry mouth
    •Eye allergy
    Common Side Effects for

    Reported in up to 15% of people in clinical studies:

    •Eye redness
    •Eye itching
    •Eye burning or stinging

  • Warnings of Simbrinza vs. Combigan

    Common Side Effects for
    •Only use in the eye
    •Severe allergic reactions
    •Risk for swelling of the cornea in certain people
    •Risk for worsening of poor blood flow
    •Risk for eye infection (from contamination)
    •Take out soft contact lenses before using
    Common Side Effects for
    •Only use in the eye
    •Allergic reaction of the eye
    •Interaction with inhaled beta agonists for asthma or COPD
    •Worsening heart problems
    •Worsening of other medical conditions
    •Masked symptoms of low blood sugar in people with diabetes
    •Masked symptoms of high thyroid hormone levels (hyperthyroidism)

  • Prices with our coupons for Simbrinza vs. Combigan

    Learn more about Simbrinza
    Learn more about Combigan

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