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Simbrinza vs. Combigan

Simbrinza is a combination eye drop containing two medications: brinzolamide (a carbonic anhydrase inhibitor) and brimonidine (an alpha-2 agonist). It's used to treat glaucoma and high pressure in the eye. The dosage for the eye drops is placed 1 drop placed directly into the eye(s) three times per day to lower the pressure in the eye. Simbrinza is not yet available as a lower-cost generic. Side effects include eye irritation, blurry vision, and changes in taste.

Treatment of high pressure in the eye in people ages 2 years and older with:

• Ocular hypertension
• Open-angle glaucoma

Reported in up to 5% of people:

• Blurry vision
• Eye irritation
• Changes in taste (e.g., bad taste in mouth)
• Dry mouth
• Eye allergy

• Only use in the eye
• Severe allergic reactions
• Risk for swelling of the cornea in certain people
• Risk for worsening of poor blood flow
• Risk for eye infection (from contamination)
• Take out soft contact lenses before using

Combigan is a combination eye drop containing brimonidine (an alpha agonist) and timolol (a beta blocker). It's used to lower high pressure inside the eye in adults with conditions like glaucoma or ocular hypertension. Typically, you apply one drop to the affected eye(s) twice daily, about 12 hours apart. Common side effects include eye redness, itching, or dryness. Combigan (brimonidine / timolol) is available as both a brand-name and generic medication.

Treatment of high pressure in the eye in people ages 2 years and older with:

• Ocular hypertension
• Open-angle glaucoma

Reported in up to 15% of people in clinical studies:

• Eye redness
• Eye itching
• Eye burning or stinging

• Only use in the eye
• Allergic reaction of the eye
• Interaction with inhaled beta agonists for asthma or COPD
• Worsening heart problems
• Worsening of other medical conditions
• Masked symptoms of low blood sugar in people with diabetes
• Masked symptoms of high thyroid hormone levels (hyperthyroidism)