Key takeaways
Mesalamine (Rowasa) and mesalamine delayed-release (DR) oral forms like Apriso, Asacol HD, Delzicol, Lialda, and Pentasa are both used to treat ulcerative colitis (UC), but they differ in their administration and some side effects. Rowasa is a rectal enema, which means you insert it into your rectum, while the DR oral forms are taken by mouth as pills or capsules. Rowasa works directly in your colon and is a good option if you have trouble swallowing pills, but it can be uncomfortable to use and may cause rectal pain or soreness. On the other hand, the DR oral forms are easier to take since you just swallow them, but you might need to take multiple pills each day, and it can take a few weeks to feel their effects. Both forms can cause kidney problems and make your skin more sensitive to the sun, but Rowasa can also cause allergic reactions if you're sensitive to sulfites. Additionally, the DR oral forms have specific instructions on whether to take them with or without food, and some forms should not be taken with antacids. Both medications have lower-cost generic options available.
