Key takeaways
Quinine (Qualaquin) and doxycycline hyclate (Vibramycin, Doryx) are both used to treat malaria caused by the parasite *Plasmodium falciparum*, but they belong to different medication classes. Quinine is an antimalarial medication, while doxycycline hyclate is a tetracycline antibiotic. Quinine is specifically FDA-approved for treating uncomplicated malaria in people aged 16 and older, whereas doxycycline hyclate is used both to treat and prevent malaria, as well as a variety of bacterial infections like respiratory tract infections, sexually transmitted infections, and severe acne. Quinine is taken as a capsule every 8 hours for 7 days, while doxycycline hyclate is typically taken once or twice daily, depending on the condition being treated. Both medications are available as lower-cost generics. Quinine has many side effects, such as nausea, dizziness, and serious heart rhythm problems. Doxycycline hyclate also has side effects, including stomach upset and increased sensitivity to sunlight. Doxycycline can interact with blood thinners and birth control pills, while quinine can interact with blood thinners and seizure medications. Both medications require a prescription, and it's important to follow your healthcare provider's instructions when taking them.
