Key takeaways
Paroxetine (Paxil) and mirtazapine (Remeron) are both medications used to treat depression, but they belong to different classes and have distinct characteristics. Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that also treats various anxiety disorders, while mirtazapine is an atypical antidepressant specifically for major depressive disorder (MDD). Paroxetine can cause side effects like nausea, sexual problems, and weight gain, and it may take several weeks to feel its full benefits. In contrast, mirtazapine is more likely to cause sleepiness and weight gain but is less likely to cause nausea or sexual issues. Both medications can lead to withdrawal symptoms if stopped abruptly. Paroxetine is available in both immediate-release and extended-release tablets. Mirtazapine is typically taken once daily at night and is available as a dissolvable tablet, which can be helpful if you have trouble swallowing pills.
