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Oxymetazoline vs. Phenylephrine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Oxymetazoline

(Afrin)

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phenylephrine eye drops

 

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Summary for Oxymetazoline

Over-the-counter

Oxymetazoline (Afrin) is a nasal decongestant spray. More specifically, it's an alpha-1 receptor agonist. Oxymetazoline (Afrin) is sprayed into the nostrils up to twice daily to help relieve stuffy noses. But you should avoid using it for longer than 3 days in a row because doing so can raise the risk for rebound congestion. There are oxymetazoline products for children and adults that differ in dosage, so read the label on your specific product to make sure it's appropriate for you. Some side effects of this medication might include mild burning or stinging in the nose.

Indications for Oxymetazoline

  • Short-term relief of nasal and sinus congestion and pressure

Pros and Cons for Oxymetazoline

Pros

  • Starts working within minutes and lasts for up to 12 hours
  • Typically fewer side effects than oral decongestants
  • Children's product can be used by those as young as 2 years old (check product labeling)
  • Available over the counter and as a lower-cost generic

Cons

  • Some nasal spray might drip out of nose, which can be messy
  • Can't use longer than 3 days due to rebound congestion
  • Might not be a good choice for people with high blood pressure
  • Not recommended during pregnancy

Common Side Effects for Oxymetazoline

  • Burning in the nose
  • Stinging in the nose
  • Rebound nasal congestion (if using longer than 3 days)

Warnings for Oxymetazoline

  • Rebound congestion
  • Might not be safe for people with certain medical conditions
  • For use in the nose only

Summary for Phenylephrine

Prescription only

Phenylephrine eye drops are used to dilate (widen) pupils for eye exams or certain eye procedures. Side effects include temporary burning or stinging in the eye, blurry vision, and possibly raise your blood pressure. Let your provider know if your pregnant or breastfeeding because you might need to use a different medication.

Indications for Phenylephrine

  • Dilate (widen) pupils

Pros and Cons for Phenylephrine

Pros

  • Can be used in adults and children
  • Starts working quickly (within 15 minutes)
  • Available as a lower-cost generic medication

Cons

  • Can cause eye pain and stinging
  • Dilating effects can last for up to 7 hours (or longer)
  • The 10% strength can raise blood pressure in people with certain heart or thyroid problems

Common Side Effects for Phenylephrine

  • Temporary stinging or burning in your eye
  • Temporary blurry vision
  • Sensitivity to light

Warnings for Phenylephrine

  • For use in the eyes only
  • Heart problems
  • High blood pressure
  • Rebound pupil constriction

Prices with our coupons for Oxymetazoline vs. Phenylephrine

Price Card Drug Icon
Oxymetazoline1 nasal spray / 15ml of 0.05%
$10.91-
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Price Card Drug Icon
Phenylephrine1 eye dropper / 2ml of 2.5%
$21.67$40.99
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