Omnicef vs. Cedax for Ear Infection and Upper Respiratory Infection: Important Differences and Potential Risks.

Key takeaways

Cefdinir (Omnicef) and ceftibuten (Cedax) are both cephalosporin antibiotics used to treat bacterial infections, such as those affecting the lungs, ears, and throat. However, there are several differences between these medications. Cefdinir is still available in generic form and can be prescribed for both adults and children, while ceftibuten is no longer available in the U.S. Cefdinir comes in capsules and oral suspension, whereas ceftibuten was available as an oral suspension before being discontinued. Cefdinir is FDA-approved for a wider range of infections, including pneumonia and skin infections, while ceftibuten was primarily used for bronchitis, otitis media, and throat infections. Common side effects of cefdinir include diarrhea, nausea, and rash, and it has specific drug interactions with antacids and iron supplements. In contrast, ceftibuten's side effects and interactions are not detailed due to its discontinuation. Additionally, cefdinir can be used off-label for urinary tract infections, especially in children, which is not mentioned for ceftibuten.

Cefdinir

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Cedax

(ceftibuten)

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Summary for Omnicef

Prescription only

Cefdinir, also known by its brand name Omnicef, is a cephalosporin antibiotic that can treat several types of bacterial infections, such as pneumonia, sinus infections, and ear infections. Although the brand name is no longer available, its generic can still be prescribed for adults and children. Cefdinir comes as capsules and a suspension that are taken once or twice per day by mouth. Side effects can include diarrhea, nausea, and rash.

Indications for Omnicef

Pneumonia
Lung infections related to long-term bronchitis
Sinus infections
Strep throat
Tonsil infections
Skin infections
Ear infections - for children only

Pros and Cons for Omnicef

Pros

Available as a capsule and oral suspension
Can be used for children and adults
Might be able to take once per day, depending on the infection
Can keep oral suspension at room temperature for up to 10 days

Cons

Might not be able to take this antibiotic if you've had a severe allergic reaction to penicillins or other cephalosporin antibiotics
Must separate when you take cefdinir and antacids or iron supplements by at least 2 hours
Oral suspension contains sugar, so people with diabetes might have higher blood sugar levels while they're taking the antibiotic
Not recommended for the cold or flu, since they're not caused by a bacterial infection

Common Side Effects for Omnicef

Diarrhea (up to 15%)

Warnings for Omnicef

Severe allergic reactions
Diarrhea from Clostridioides difficile infection
Possible development of drug-resistant bacteria

Summary for Cedax

Discontinued

Cedax (ceftibuten) is a cephalosporin antibiotic that treats bacterial infections of the lungs (bronchitis), ears (otitis media), and throat (strep throat and tonsillitis). It is no longer available in the U.S.