Key takeaways
Amlodipine (Norvasc) and Nisoldipine (Sular) are both calcium channel blockers used to treat high blood pressure. Amlodipine is also approved for treating coronary artery disease, while Nisoldipine is not. Amlodipine is available in both tablet and liquid forms, making it easier for people who have trouble swallowing pills, whereas Nisoldipine only comes as a tablet and must be swallowed whole and cannot be crushed or chewed. Amlodipine is available as a lower-cost generic, while Nisoldipine, even in its generic form, tends to be more expensive. Common side effects of Amlodipine include swelling and tiredness, while Nisoldipine often causes headaches in addition to swelling in the legs and feet. Both medications can cause dizziness, especially when starting or increasing the dose, but Nisoldipine requires you to avoid grapefruit products, which can increase the chance of side effects.
