Key takeaways
Nifedipine ER (Procardia XL) and hydrochlorothiazide (Microzide) are both used to treat high blood pressure, but they work in different ways and belong to different medication classes. Nifedipine ER is a calcium channel blocker (CCB) that relaxes blood vessels to improve blood flow and reduce chest pain, while hydrochlorothiazide is a diuretic (water pill) that helps your body get rid of extra fluid and certain electrolytes to lower blood pressure and reduce swelling. Nifedipine ER is taken once daily, whereas hydrochlorothiazide is typically taken once or sometimes twice daily. Common side effects of nifedipine ER include swelling in the legs, dizziness, and headaches, while hydrochlorothiazide often causes dizziness, increased urination, and sensitivity to sunlight. Nifedipine ER is available in a lower-cost generic form, and hydrochlorothiazide is also available as a cheaper generic. Hydrochlorothiazide can cause electrolyte imbalances and may raise blood sugar levels, while nifedipine ER can cause low blood pressure and, in rare cases, heart failure or stomach issues.
