Key takeaways
Nayzilam (midazolam) and Fycompa (perampanel) are both medications used to treat seizures, but they have some key differences. Nayzilam is a benzodiazepine nasal spray used for quick relief during seizure attacks in people 12 years and older. It works by slowing down brain activity and is only available as a brand-name medication. On the other hand, Fycompa is an antiepileptic taken orally, either as a liquid or tablet, and is used for long-term control of partial-onset seizures in people 4 years and older and generalized tonic-clonic seizures in people 12 years and older. Fycompa is also only available as a brand-name medication. While Nayzilam is used on an as-needed basis for immediate seizure control, Fycompa is taken once daily to prevent seizures. Both medications can cause drowsiness and have risks of misuse and dependence, but Fycompa also has a higher risk of mood changes and weight gain. Additionally, Nayzilam is a Schedule IV controlled substance, whereas Fycompa is a Schedule III controlled substance, indicating a higher potential for misuse with Fycompa.
