Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Valtoco vs. Nayzilam

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Valtoco (diazepam) and Nayzilam (midazolam) are both benzodiazepines used to treat seizure attacks in people with epilepsy, but they have some key differences. Valtoco is approved for use in children as young as 6 years old, while Nayzilam is only for those 12 and older. Valtoco comes in multiple doses (5 mg, 10 mg, 15 mg, and 20 mg), whereas Nayzilam is available in a single 5 mg dose. Valtoco can be used up to twice in a 24-hour period, and Nayzilam allows for a second dose if the seizure isn't controlled after 10 minutes. Both medications are nasal sprays and work quickly, but Valtoco typically works within 4 minutes, while Nayzilam can take up to 10 minutes. Additionally, Valtoco and Nayzilam are only available as a brand-name medication. Common side effects for both include drowsiness, headache, and nasal discomfort.

  • Valtoco (diazepam)
    Nayzilam (midazolam)
  • Valtoco (diazepam)
    Nayzilam (midazolam)

  • Summary of Valtoco vs. Nayzilam

    Summary for Benzodiazepine
    Prescription only

    Valtoco (diazepam) is a prescription medication that's used for short-term treatment of seizures in adults and children 2 years of age and older. It comes as a ready-to-use nasal spray device, but the person giving the medication must know when and how to give it correctly. Common side effects of Valtoco (diazepam) include feeling sleepy, headache, and nasal discomfort.

    Summary for Benzodiazepine
    Prescription only

    Nayzilam (midazolam) is a nasal spray that quickly treats seizure attacks in people with a seizure condition called epilepsy. It comes in a ready-to-use spray device, but the person giving the medication must know when and how to give it properly. Nayzilam (midazolam) commonly causes drowsiness, throat irritation, and nasal discomfort. Nayzilam (midazolam) is only available as a brand-name medication.

  • Indications of Valtoco vs. Nayzilam

    Indications for
    •Seizures in people with epilepsy who are 2 years and older
    Indications for
    •Seizure attacks in people with epilepsy who are 12 years of age and older

  • Pros and Cons of Valtoco vs. Nayzilam

    Pros and Const for Benzodiazepine
    Pros
    •Approved for people 2 years of age and older
    •Works quickly treat seizures typically within 4 minutes
    •Might help prevent another seizure attack from happening within 24 hours
    •Easy for someone to give the medication as a nasal spray
    •Good option for someone who can't take anything by mouth, such as in the middle of a seizure attack
    Cons
    •Can cause sleepiness, headache, and nasal discomfort
    •Might not be the safest option during pregnancy or breastfeeding
    •Only for treatment of seizure attacks, not for long-term seizure control
    •Care partners need special training to know when and how to give it correctly
    •Potentially interact with many medications
    Pros and Const for Benzodiazepine
    Pros
    •Works within 10 minutes to treat seizure attacks
    •Might help prevent another seizure attack from happening within 24 hours
    •Good option for someone who can't take anything by mouth, such as in the middle of a seizure attack
    Cons
    •Only for treating seizure attacks, not for long-term seizure control
    •Caregivers need special training to know when and how to give the medication properly.
    •Can't use in children younger than 12 years of age
    •Only available as a brand-name medication

  • Common Side Effects of Valtoco vs. Nayzilam

    Common Side Effects for
    •Feeling sleepy or drowsy (23%)
    •Nasal discomfort (6%)
    •Headache (5%)
    •Diarrhea (4%)
    •Changes in taste (3%)
    Common Side Effects for
    •Drowsiness (10%)
    •Nasal discomfort (9%)
    •Headache (4%)
    •Throat irritation (3%)
    •Runny nose (3%)

  • Warnings of Valtoco vs. Nayzilam

    Common Side Effects for
    •Sedation and difficulty breathing
    •Risk of misuse and addiction
    •Dependence and withdrawal
    •Difficulty with concentration and focus
    •Suicidal thoughts or behaviors
    •Rise in eye pressure in people with glaucoma
    •Do not give to babies
    Common Side Effects for
    •Extreme sleepiness and difficulty breathing
    •Misuse and addiction
    •Dependence and withdrawal
    •Suicidal thoughts or behaviors
    •Difficulty with concentration, focus, and memory
    •Rise in eye pressure in people with glaucoma

  • Prices with our coupons for Valtoco vs. Nayzilam

    Learn more about Valtoco
    Learn more about Nayzilam

Compare other Epilepsy drugs

Valtoco vs NayzilamImitrex vs KeppraKeppra vs BriviactKeppra vs DepakoteKeppra vs VimpatLamictal vs KeppraLasix vs KeppraNayzilam vs FycompaNayzilam vs KeppraNayzilam vs PotigaNeptazene vs KeppraNeurontin vs KeppraPropranolol vs KeppraTegretol vs KeppraTimolol vs KeppraTopamax vs KeppraTrileptal vs KeppraTrusopt vs Keppra
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.