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Compare Nayzilam vs. Fycompa

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Nayzilam (midazolam) and Fycompa (perampanel) are both medications used to treat seizures, but they have some key differences. Nayzilam is a benzodiazepine nasal spray used for quick relief during seizure attacks in people 12 years and older. It works by slowing down brain activity and is only available as a brand-name medication. On the other hand, Fycompa is an antiepileptic taken orally, either as a liquid or tablet, and is used for long-term control of partial-onset seizures in people 4 years and older and generalized tonic-clonic seizures in people 12 years and older. Fycompa is also only available as a brand-name medication. While Nayzilam is used on an as-needed basis for immediate seizure control, Fycompa is taken once daily to prevent seizures. Both medications can cause drowsiness and have risks of misuse and dependence, but Fycompa also has a higher risk of mood changes and weight gain. Additionally, Nayzilam is a Schedule IV controlled substance, whereas Fycompa is a Schedule III controlled substance, indicating a higher potential for misuse with Fycompa.

  • Nayzilam (midazolam)
    Fycompa (perampanel)
  • Nayzilam (midazolam)
    Fycompa (perampanel)

  • Summary of Nayzilam vs. Fycompa

    Summary for Benzodiazepine
    Prescription only

    Nayzilam (midazolam) is a nasal spray that quickly treats seizure attacks in people with a seizure condition called epilepsy. It comes in a ready-to-use spray device, but the person giving the medication must know when and how to give it properly. Nayzilam (midazolam) commonly causes drowsiness, throat irritation, and nasal discomfort. Nayzilam (midazolam) is only available as a brand-name medication.

    Summary for Antiepileptic
    Prescription only

    Fycompa (perampanel) is an antiseizure medication that's used to control certain types of seizures. It's available as a liquid and tablet that's taken by mouth. While it's convenient because the dosage is taken once per day, Fycompa (perampanel) is a schedule III controlled substance and can have a lot of side effects, including sleepiness, dizziness, and weight gain. This medication is not yet available as a lower-cost generic.

  • Indications of Nayzilam vs. Fycompa

    Indications for
    •Seizure attacks in people with epilepsy who are 12 years of age and older
    Indications for
    •Partial-onset seizures in people ages 4 years and older
    •Generalized tonic-clonic seizures in people ages 12 years and older (add-on therapy to other seizure medications)

  • Pros and Cons of Nayzilam vs. Fycompa

    Pros and Const for Benzodiazepine
    Pros
    •Works within 10 minutes to treat seizure attacks
    •Might help prevent another seizure attack from happening within 24 hours
    •Good option for someone who can't take anything by mouth, such as in the middle of a seizure attack
    Cons
    •Only for treating seizure attacks, not for long-term seizure control
    •Caregivers need special training to know when and how to give the medication properly.
    •Can't use in children younger than 12 years of age
    •Only available as a brand-name medication
    Pros and Const for Antiepileptic
    Pros
    •Works well for seizures
    •Only taken once per day
    •Available as a liquid and tablet
    Cons
    •Causes dizziness and raises your risk of falls
    •Can cause dangerous changes in mood, thoughts, or behavior
    •Might not be a safe choice for pregnant women

  • Common Side Effects of Nayzilam vs. Fycompa

    Common Side Effects for
    •Drowsiness (10%)
    •Nasal discomfort (9%)
    •Headache (4%)
    •Throat irritation (3%)
    •Runny nose (3%)
    Common Side Effects for
    •Dizziness (up to 43%)
    •Sleepiness (up to 18%)
    •Headache (up to 13%)
    •Feeling irritable (up to 12%)
    •Tiredness (up to 12%)
    •Falls (up to 10%)
    •Nausea or vomiting (up to 8%)
    •Difficulty with movement or coordination (up to 8%)

  • Warnings of Nayzilam vs. Fycompa

    Common Side Effects for
    •Extreme sleepiness and difficulty breathing
    •Misuse and addiction
    •Dependence and withdrawal
    •Suicidal thoughts or behaviors
    •Difficulty with concentration, focus, and memory
    •Rise in eye pressure in people with glaucoma
    Common Side Effects for
    •Abnormal mood, thoughts, or behavior
    •Suicidal thoughts or behavior
    •Difficulty concentrating, extreme sleepiness, dizziness, and loss of balance
    •Severe allergic and skin reactions
    •Risk of seizures and withdrawal symptoms if stopped suddenly

  • Prices with our coupons for Nayzilam vs. Fycompa

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