Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Fluvoxamine (Luvox) and sertraline (Zoloft) are both selective serotonin reuptake inhibitors (SSRIs) used to treat mental health conditions, but they have some key differences. Fluvoxamine is primarily used to treat obsessive-compulsive disorder and is available only in generic form, while Zoloft is used to treat a wider range of conditions, including major depressive disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, and social anxiety disorder. Fluvoxamine can be taken once or twice daily, depending on the form, whereas Zoloft is typically taken once daily. Both medications can cause side effects like nausea and sleep problems, but fluvoxamine is more likely to cause side effects such as diarrhea and has a higher risk of medication interactions. Zoloft, on the other hand, is less likely to cause weight gain compared to some other SSRIs and has fewer interactions. Both medications shouldn't be stopped abruptly to avoid withdrawal symptoms, and alcohol should be avoided while taking them.
Fluvoxamine
Sertraline (Zoloft)
Fluvoxamine
Sertraline (Zoloft)
Summary of Luvox vs. Zoloft
Summary for SSRI
Prescription only
Fluvoxamine maleate is an SSRI, or a selective serotonin reuptake inhibitor. It's approved to treat obsessive-compulsive disorder (OCD) in people ages 8 years and up. Fluvoxamine comes as immediate-release tablets taken by mouth once or twice a day. For adults, it also comes as extended-release capsules taken once a day. Your specific dosage depends on which form you're taking. Side effects include nausea, sleepiness or trouble sleeping, and headache. Fluvoxamine is a generic medication; the brand name Luvox is no longer available.
Summary for SSRI
Prescription only
Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI). It's used to treat different mental health conditions, including depression and certain types of anxiety disorder, such as panic disorder. It's typically taken by mouth once per day. This medication is available as both a tablet and liquid. Common side effects of sertraline (Zoloft) include nausea, diarrhea, and dry mouth. It's best to avoid alcohol while taking sertraline (Zoloft) because this combination can worsen side effects of sertraline (Zoloft).