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Lunesta vs. Ativan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lunesta (eszopiclone) and Lorazepam (Ativan) are both medications used to help with sleep and anxiety, but they work in different ways and are used for different purposes. Lunesta is a sedative-hypnotic used to treat insomnia, helping you fall asleep faster and stay asleep longer. It is taken right before bedtime and can cause side effects like a bad taste in your mouth and headaches. Lorazepam, on the other hand, is a benzodiazepine used for short-term treatment of anxiety and is also available as an injection for seizures. It can cause sleepiness and dizziness and has a higher risk of dependence and withdrawal symptoms compared to Lunesta. While both medications are controlled substances, Lorazepam is more likely to be habit-forming. Additionally, Lorazepam should not be taken with alcohol or opioid pain medications due to the risk of severe side effects, including trouble breathing.

Lunesta

(eszopiclone)

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Lorazepam

(Ativan)

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Summary for Lunesta

Prescription only

Lunesta (eszopiclone) is used to treat insomnia in people over the age of 18. This medication can help you fall asleep faster and wake up fewer times during the night. Lunesta (eszopiclone) belongs to a drug class called sedative-hypnotics, and it's a controlled substance so there are restrictions on how it can be filled and refilled at the pharmacy. You typically only need to take a dose right before bedtime, but it can cause a headache or leave a bad taste in your mouth as a side effect.

Indications for Lunesta

  • Insomnia (trouble falling or staying asleep)

Pros and Cons for Lunesta

Pros

  • Available as a lower-cost generic
  • Can help you fall asleep and stay asleep
  • Fewer side effects and less addicting than some other sleep medications

Cons

  • Can cause sedation, dizziness, and poor coordination the next day, especially at higher doses
  • Can lead to rebound insomnia after stopping the medication, especially if you've taken it for a long time
  • Risk of abnormal sleep behaviors, such as sleepwalking or sleep driving

Common Side Effects for Lunesta

Warnings for Lunesta

  • Abnormal sleep behaviors
  • Poor mental alertness
  • Behavior changes and abnormal thinking
  • Severe allergic reactions
  • Follow up with provider to check for other reasons for insomnia
  • Withdrawal
  • Use with caution in older adults and people with certain health conditions

Summary for Ativan

Prescription only

Lorazepam (Ativan) is a benzodiazepine used for short-term treatment of anxiety. The oral tablets and solution are taken by mouth, typically 1 to 3 times daily, depending on the formulation. Lorazepam is also available as an injectable medication that's given by healthcare professionals in a hospital setting to control seizures. Sleepiness and dizziness are the most common side effects of lorazepam (Ativan).

Indications for Ativan

Pros and Cons for Ativan

Pros

  • Taken by mouth
  • Might start to work within 30 minutes to manage anxiety symptoms
  • Available as oral solution, good option for those who can't swallow tablets
  • Some forms available as a lower-cost generic

Cons

  • Short-term use only because risk of dependence and memory problems
  • Can drowsiness, and dizziness
  • Can cause withdrawal symptoms if stopped suddenly
  • Can't take with alcohol

Common Side Effects for Ativan

  • Sleepiness (16%)
  • Dizziness (7%)
  • Weakness (4%)
  • Unsteadiness (3%)

Warnings for Ativan

  • Sedation and difficulty breathing
  • Misuse, dependence, and withdrawal
  • Depression and suicidal thoughts or behaviors
  • Effect on driving and concentration
  • Trouble breathing
  • Risk of agitation and restlessness
  • Harm to babies
  • Serious allergic reaction (Loreev XR only)

Prices with our coupons for Lunesta vs. Ativan

Price Card Drug Icon
Eszopiclone30 tablets / 3mg
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Lorazepam30 tablets / 1mg
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