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Ibuprofen vs. Plavix

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ibuprofen (Advil, Motrin) and clopidogrel (Plavix) are both medications that can be used to manage conditions related to the heart and blood vessels, but they belong to different medication classes and have distinct uses. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain, reduce fever, and alleviate inflammation. It is available over-the-counter and by prescription, and it can be taken in various oral forms such as tablets, capsules, and liquid. Clopidogrel, on the other hand, is a P2Y12 inhibitor, which is a type of antiplatelet medication used to prevent heart attacks and strokes by helping treat and prevent blood clots. It is only available by prescription and is typically taken as a tablet once a day. While ibuprofen can cause side effects like nausea and stomach pain, clopidogrel's most common side effects include bleeding and bruising. Additionally, ibuprofen can interact with other NSAIDs and blood pressure medications, and clopidogrel can interact with NSAIDs as well as medications like omeprazole and certain antidepressants. It's important to note that ibuprofen is not a blood thinner, but it can increase bleeding risk, especially when taken with clopidogrel or other blood thinners.

Ibuprofen

 

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Clopidogrel

(Plavix)

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Summary for Ibuprofen

Prescription or over-the-counter

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that's used to temporarily relieve fever, pains, and aches in adults and children. In general, ibuprofen is taken by mouth every 4 to 8 hours, though the dosage depends on your age, weight, and other medical problems. Ibuprofen side effects include nausea, heartburn, and stomach pain, but taking it with food might help prevent these side effects. Ibuprofen is available over the counter and by prescription, depending on the strength you need.

Indications for Ibuprofen

Over-the-counter ibuprofen:

Prescription ibuprofen:

Pros and Cons for Ibuprofen

Pros

  • Works well for fever, pain, and swelling
  • Available over the counter and by prescription and as lower-cost generics
  • Available as tablets, capsules, chewable tablets, and an oral liquid
  • Chewable tablets and liquid can be used in children

Cons

  • Lasts for only about 6 hours, so might need to take multiple doses throughout the day
  • Might not be the best option if you're 65 years or older or if you have kidney, heart, liver, or bleeding problems
  • Has risk of stomach bleeding, stomach ulcers, and kidney problems
  • Shouldn't take other NSAIDs at the same time because of higher risk for side effects

Common Side Effects for Ibuprofen

The following side effects were reported in up to 9% of people in clinical studies.

  • Nausea
  • Stomach pain
  • Heartburn
  • Dizziness
  • Rash

Warnings for Ibuprofen

  • Stomach bleeding and ulcers
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Kidney damage
  • Liver problems
  • Severe allergic reactions
  • Harm to unborn babies
  • Caution use in people with phenylketonuria (PKU) - chewable tablets only

Summary for Plavix

Prescription only

Clopidogrel (Plavix) is a prescription antiplatelet medication that helps lower your risk of heart attack or stroke. It works by stopping platelets in your blood from sticking together and forming clots. You take it as a tablet by mouth once a day, and it might be used alone or with aspirin in some situations. Since it's a blood thinner, the most common side effect is bleeding.

Indications for Plavix

Pros and Cons for Plavix

Pros

  • Good choice for lowering the risk of heart attack or stroke
  • Tablet that's taken once a day by mouth
  • Can be taken with or without food

Cons

  • Can cause major bleeding or bruising
  • Has many interactions with other medications
  • Might not work as well for people with East Asian descent

Common Side Effects for Plavix

  • Minor bleeding (5%)
  • Major bleeding (4%)

Warnings for Plavix

  • Clopidogrel (Plavix) not working as well
  • Bleeding
  • Risk of heart attack or stroke if stopped suddenly
  • Blood clotting condition
  • Allergic reaction

Prices with our coupons for Ibuprofen vs. Plavix

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Ibuprofen30 tablets / 800mg
$8.92$16.20
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Clopidogrel30 tablets / 75mg
$10.83$89.67
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