Key takeaways
Ibuprofen (Advil, Motrin) and naproxen (Naprosyn, Aleve) are both nonsteroidal anti-inflammatory drugs (NSAIDs) used to relieve pain and inflammation, but they have some differences. One key difference is that ibuprofen is available both over-the-counter and by prescription, while naproxen is typically prescription-only, though an over-the-counter version (Aleve) exists. Ibuprofen is usually taken every 4 to 6 hours, whereas naproxen is taken less frequently, every 8 to 12 hours, due to its longer-lasting effects. Both medications can cause side effects like stomach pain, nausea, and heartburn, but naproxen is more likely to cause drowsiness. Additionally, both medications can raise blood pressure and have risks of stomach bleeding, but naproxen may also cause constipation. It's important to take either medication with food or milk to minimize stomach issues and to avoid taking them together or with other NSAIDs to reduce the risk of serious side effects.
