Key takeaways
Ibuprofen (Advil, Motrin) and etodolac (Lodine) are both nonsteroidal anti-inflammatory drugs (NSAIDs) used to relieve pain and inflammation. However, there are some key differences between them. Ibuprofen is available both over-the-counter and by prescription, while etodolac is only available by prescription. Ibuprofen can be used for a variety of short-term pains, such as headaches and muscle aches, and is also used to reduce fever. Etodolac, on the other hand, is primarily used for osteoarthritis, rheumatoid arthritis, and short-term pain, with an extended-release form available for children with juvenile idiopathic arthritis. Ibuprofen is taken every 4 to 8 hours, whereas etodolac's immediate-release form is taken every 6 to 8 hours, and the extended-release form is taken once daily. Both medications can cause stomach pain and other gastrointestinal issues, but etodolac has a higher risk of causing constipation. Additionally, neither medication should be taken during the second half of pregnancy due to potential risks to the unborn baby.
