Key takeaways
Guanfacine (Intuniv) and Vyvanse (lisdexamfetamine) are both medications that can be used to treat attention-deficit hyperactivity disorder (ADHD), but they belong to different medication classes. Guanfacine is an alpha-2 adrenergic receptor agonist; its immediate-release form is used to treat high blood pressure, and its extended-release form (Intuniv) is approved for ADHD. Vyvanse, on the other hand, is a stimulant and is FDA-approved for ADHD and binge eating disorder (BED) in adults. Guanfacine is typically taken once a day in the morning or evening, while Vyvanse is taken once a day in the morning. Both medications are available as a lower-cost generic and a brand-name medication. Vyvanse is a controlled substance with a high risk of misuse and dependence. Common side effects of guanfacine include sleepiness and dizziness, while Vyvanse can cause difficulty sleeping and loss of appetite. Guanfacine can interact with medications that cause drowsiness, while Vyvanse has many potential drug interactions, including with medications that affect serotonin levels.
