Key takeaways
Granisetron (generic name) and Metoclopramide (generic name, brand name Reglan) are both used to manage nausea and vomiting, but they work differently and are used for different conditions. Granisetron is an antiemetic that blocks serotonin to prevent nausea and vomiting caused by chemotherapy and radiation. It is available in oral and intravenous forms and is typically taken only on treatment days. Common side effects include headaches and constipation. Metoclopramide, on the other hand, is a dopamine antagonist used to treat gastroesophageal reflux disease (GERD) and diabetic gastroparesis. It can also be used off-label for nausea and vomiting from chemotherapy, but it is not a first-choice option due to its risk of serious side effects like tardive dyskinesia. Metoclopramide is available in various forms, including tablets and nasal spray, and must be taken multiple times a day. It can cause drowsiness and other side effects like restlessness and depression. While both medications are available in generic forms, Metoclopramide has a broader range of uses but comes with more significant risks.
