Key takeaways
Flutamide (Eulexin) and Nilutamide (Nilandron) are both androgen receptor inhibitors used to treat metastatic prostate cancer. Flutamide is taken three times a day, while Nilutamide is taken once a day, making Nilutamide more convenient. Flutamide must be used with another hormonal medication that targets LHRH, whereas Nilutamide is often used with surgical or medical castration. Both medications can cause hot flashes and liver problems, but Nilutamide can also cause difficulty with night vision and serious lung issues. Flutamide can also cause diarrhea and has interactions with warfarin. Both medications are available as lower-cost generics.
