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Flonase vs. Zyrtec

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Flonase (fluticasone) and Zyrtec (cetirizine) are both used to treat allergy symptoms, but they have several differences. Flonase is a corticosteroid nasal spray that reduces inflammation in your nose to relieve symptoms like congestion, runny nose, and sneezing. It is available both by prescription and over-the-counter (OTC). On the other hand, Zyrtec is an antihistamine taken orally, either as a tablet or liquid, that blocks histamine to relieve symptoms like itchy eyes, runny nose, and sneezing. Zyrtec is also available in generic form and can be taken once a day. While Flonase is used daily and can take several days to show full benefits, Zyrtec starts working within 20 to 60 minutes. Flonase can cause side effects like nosebleeds and sore throat, while Zyrtec can make you sleepy and cause dry mouth. Additionally, Flonase is safe for children as young as 2 years old in some formulations, whereas Zyrtec is not recommended for children under 6 years old in pill form.

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fluticasone nasal spray

 

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Cetirizine

(Zyrtec)

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Summary for Flonase

Prescription or over-the-counter

Fluticasone nasal spray is used to treat allergy symptoms, like runny nose and sneezing. Fluticasone nasal spray comes in brand and generic forms, and is available by a prescription or over-the-counter (OTC). Fluticasone nasal spray must be used daily in order for you to experience the maximum benefits. But if you're using OTC versions of this medication, don't use it for more than 6 months at a time (or 2 months at a time, for children) without first speaking to your provider.

Indications for Flonase

Nasal symptoms from allergies, such as:

  • Congestion
  • Runny nose
  • Sneezing
  • Itchy nose
  • Itchy, watery eyes

Pros and Cons for Flonase

Pros

  • Only has to be used once a day and can last up to 24 hours
  • Available OTC
  • Some formulations have generic versions
  • Can be used safely in children as young as 4 years old
  • Flonase Sensimist is a gentler version that can be used in children as young as 2 years old

Cons

  • Not a good option if you have an injured nose or had recent nasal surgery
  • Can raise the risk of bleeding and fungal infections in the nose
  • Can slow down growth rate in children if used for longer than 2 months per year
  • Can raise the risk for certain eye problems

Common Side Effects for Flonase

  • Headache (7-16%)
  • Sore throat (6-8%)
  • Nosebleeds (6-7%)
  • Asthma symptoms (3-7%)

Warnings for Flonase

  • Nasal problems
  • Slowed growth rate in children
  • Eye problems
  • Higher risk of infections
  • Stress hormone problems (adrenal gland problems)
  • Serious allergic reactions

Summary for Zyrtec

Prescription or over-the-counter

Cetirizine (Zyrtec) is an antihistamine. It's used for relief of allergy symptoms, such as runny nose or watery eyes, in adults and children. Cetirizine (Zyrtec) is also a safe option for people who are pregnant. This medication is available in different formulations, including tablets and liquid solutions. Typically, cetirizine (Zyrtec) is taken by mouth once per day. The most common side effect of cetirizine (Zyrtec) is sleepiness. But it's less likely to make you drowsy compared to some other antihistamines, such as diphenhydramine (Benadryl).

Indications for Zyrtec

  • Short-term relief of allergy symptoms (sneezing, runny nose, itchy or watery eyes, itching of the nose or throat)
  • Relief of itchiness due to chronic (long-term) hives in children ages 6 months to under 6 years old - certain liquid solutions only

Pros and Cons for Zyrtec

Pros

  • First-choice option for relieving allergy symptoms
  • Taken once per day
  • Available in several formulations (e.g., pills, chewable tablets, orally disintegrating tablets, liquids)
  • Safe to take while pregnant

Cons

  • Can cause you to feel sleepy
  • Higher risk of side effects in people with liver or kidney problems
  • Pills can't be used in children younger than 6 years.

Common Side Effects for Zyrtec

People 12 years of age and older:

  • Sleepiness (14%)
  • Tiredness (6%)
  • Dry mouth (5%)

Children age 6 to under 12 years:

  • Headache (11-14%)
  • Sore throat (3-6%)
  • Stomach pain (4-6%)
  • Cough (3-4%)
  • Sleepiness (2-4%)

Warnings for Zyrtec

  • Sleepiness
  • Accidentally taking too much medication

Prices with our coupons for Flonase vs. Zyrtec

Price Card Drug Icon
Fluticasone Propionate1 nasal spray / 16g of 50mcg
$14.67$47.00
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Cetirizine90 tablets / 24 hour of 10mg
$9.11$14.04
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