Key takeaways
Fluticasone nasal spray (Flonase, Flonase Sensimist) and brompheniramine/phenylephrine (Dimetapp Cold and Allergy) are both used to treat allergy symptoms, but they belong to different medication classes. Fluticasone is a corticosteroid that reduces inflammation in the nose, while brompheniramine/phenylephrine is a combination of an antihistamine and a decongestant that relieves symptoms like sneezing and congestion. Fluticasone is available as a nasal spray, either by prescription or over-the-counter, and is used daily for ongoing relief. In contrast, brompheniramine/phenylephrine is taken orally in liquid or tablet form and can be used as needed. Both medications are available in generic form and are available over-the-counter without a prescription. Common side effects of fluticasone include headaches and nosebleeds, whereas brompheniramine/phenylephrine can cause dizziness and sleepiness. Additionally, brompheniramine/phenylephrine may not be suitable for people with certain health conditions like high blood pressure, while fluticasone may increase the risk of nasal and eye problems with long-term use.
