Brompheniramine/phenylephrine is a combination medication that helps to temporarily relieve symptoms of cold and allergies, such as watery eyes, stuffy nose, and itchy throat. It's taken by mouth and available in both a liquid and a tablet form, and as lower-cost generic medications.
Short-term relief of symptoms from allergies and the common cold:
Nasal congestion
Runny nose
Sneezing
Itching of the nose or throat
Itchy or watery eyes
Brompheniramine/phenylephrine is a combination of two medications that work together to relieve symptoms caused by allergies and the common cold.
Brompheniramine (an antihistamine) blocks histamine, a chemical that causes sneezing, itching, and other allergy or cold symptoms.
Phenylephrine (a decongestant) makes the blood vessels around your nose and sinus more narrow, which helps to relieve congestion and pressure.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Combines two medications into one product for convenience
Can treat multiple allergy and common cold symptoms
Available over the counter without a prescription
Might need to take multiple times a day to relieve symptoms
More difficult to customize the dose since it's a fixed combination
Might not be a good choice for people over 65 years old or people with glaucoma, breathing problems, stomach problems, or urinary problems
Brompheniramine/phenylephrine liquid comes with a medication dosing cup. Be sure to use this cup to measure your dose of brompheniramine/phenylephrine. Don't use household spoons to measure because they're not accurate and might cause you to take the wrong dose.
Don't drink alcohol while taking this medication because it can make you more tired and dizzy. Don't drive or do anything that needs a lot of focus until you know how this medication affects you.
Brompheniramine/phenylephrine can raise your blood pressure. If you have heart problems or high blood pressure, ask your provider if it's safe for you to take brompheniramine/phenylephrine.
Stop using brompheniramine/phenylephrine and contact your provider if you get nervous, dizzy, or can't sleep. Contact your provider also if your symptoms don't get better within a week of starting brompheniramine/phenylephrine or if you develop a fever. These might be signs that you need more medical attention.
Don't start any new medications while taking brompheniramine/phenylephrine, especially other antihistamines or decongestants, without talking to your provider or pharmacist first. Doing so can raise your risk of overdose and severe side effects, including seizures, hallucinations (seeing things that are not real), daytime sleepiness, dizziness, and high blood pressure, or even death.
Don't take brompheniramine/phenylephrine if you're taking or have taken an monoamine oxidase inhibitor (MAOI), such as selegiline (Eldepryl) or phenelzine (Nardil), within the past 2 weeks. This combination can cause dangerous changes to your blood pressure. If you have taken an MAOI in the past 2 weeks, contact your provider for other options to treat your symptoms.
Store brompheniramine/phenylephrine up and away and out of children's reach and sight. Always put medication away every time you use it. This prevents them from accidentally swallowing any medication that was left out. If you think that your child might’ve accidentally swallowed brompheniramine/phenylephrine, call your Poison Control Center at 1-800-222-1222 right away even if you aren't completely sure.
Brompheniramine/phenylephrine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Glaucoma | Heart problems | High blood pressure | Thyroid problems | High blood sugar | Breathing problems | Urinary problems
Don't take brompheniramine/phenylephrine if you have any of the risk factors listed above unless your provider said it was safe to do so. Taking brompheniramine/phenylephrine can worsen your condition(s) and cause serious side effects. Make sure your provider knows about all medical conditions you have or have had in the past before starting brompheniramine/phenylephrine.
Brompheniramine/phenylephrine contains an antihistamine (brompheniramine) and a decongestant (phenylephrine), which are in many other over-the-counter products. Using more than one medication containing an antihistamine or decongestant, including products used on the skin, can lead to an accidental overdose and cause rare, but serious side effects, including high blood pressure, daytime sleepiness, dizziness, seizures, hallucinations (seeing things that are not real), or even death. Don't start any new medications while taking brompheniramine/phenylephrine without talking to your provider or pharmacist. If you're not sure if a product has an antihistamine or a decongestant, ask your pharmacist. If you or your loved one experiences an accidental overdose, get medical help right away or contact a poison control center at 1-800-222-1222.
Brompheniramine/phenylephrine made by different manufacturers might have different directions and age-cutoffs. To make sure you're taking this medication correctly, follow the specific product instructions on the package or talk with your provider or pharmacist about how to take it. Some examples include:
Each 10 mL of Dimetapp Cold & Allergy contains 2 mg of brompheniramine and 5 mg of phenylephrine
Adult and children age 12 years and older: The typical dose is 20 mL by mouth every 4 hours. Don't take more than 6 doses in a 24-hour period.
Children age 6 years to under 12 years old: The typical dose is 10 mL by mouth every 4 hours. Don't take more than 6 doses in a 24-hour period.
Children age younger than 6 years old: Don't take.
Each tablet of Ru-Hist D contains 4 mg of brompheniramine and 10 mg of phenylephrine
Adult and children age 12 years and older: The typical dose is 1 tablet by mouth every 4 hours. Don't take more than 6 tablets in a 24-hour period.
Children age 6 years to under 12 years: The typical dose is 1/2 tablet by mouth every 4 hours. Don't take more than 3 tablets in a 24-hour period.
Children age less than 6 years: Ask your child's provider.
Use as a sedative for children
Taking a MAOI in the last 14 days
Short-term relief of symptoms from allergies and the common cold:
Nasal congestion
Runny nose
Sneezing
Itching of the nose or throat
Itchy or watery eyes
Runny nose
Sneezing
Itching of the nose or throat
Itchy or watery eyes
Nasal and sinus congestion
Runny nose
Sneezing
Itchy or watery eyes
Itchy nose or throat
Stuffy nose
Sinus congestion and pressure
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Centers for Disease Control and Prevention. (2023). Put your medicines up and away out of sight.
Foundation Consumer Brands. (2022). DIMETAPP COLD AND ALLERGY- brompheniramine maleate and phenylephrine hydrochloride elixir [package insert]. DailyMed.
Gilboa, S. M., et al. (2013). Use of antihistamine medications during early pregnancy and isolated major malformations. Birth Defects Research, Part A, Clinical and Molecular Teratology.
MedlinePlus. (2021). Enlarged prostate.
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