Key takeaways
Dextromethorphan (Delsym) and brompheniramine / phenylephrine (Dimetapp Cold and Allergy) are both over-the-counter medications used to relieve symptoms of the common cold. However, they belong to different medication classes and have distinct uses. Dextromethorphan is an antitussive, which means it helps suppress coughs by acting on the brain's cough center. It is available in both extended-release and immediate-release forms and is typically taken every 6 to 12 hours. Common side effects include nausea and stomach upset, with drowsiness being less common. On the other hand, brompheniramine / phenylephrine is a combination of an antihistamine and a decongestant, used to relieve symptoms like nasal congestion, runny nose, and itchy eyes. It can be taken every 4 hours and can cause dizziness, sleepiness, and dry mouth. While dextromethorphan can interact with medications that raise serotonin levels, brompheniramine / phenylephrine can worsen conditions like high blood pressure and should not be taken with monoamine oxidase inhibitors (MAOIs). Both medications should be used with caution to avoid overdose, especially since they are common ingredients in many cold and flu products.
