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Exforge vs. Twynsta

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Exforge (amlodipine/valsartan) and telmisartan/amlodipine (Twynsta) are both combination medications used to treat high blood pressure in adults, but they have some differences. Exforge combines amlodipine, a calcium channel blocker (CCB), with valsartan, an angiotensin II receptor blocker (ARB). On the other hand, telmisartan/amlodipine combines amlodipine with telmisartan, another ARB. Both medications are taken once daily and are available as generics, making them more affordable. However, the brand name for telmisartan/amlodipine, Twynsta, has been discontinued. Common side effects for both include swelling and dizziness, but telmisartan/amlodipine can also cause back pain. Neither medication is safe to use during pregnancy or breastfeeding. Both medications are effective and provide the convienence of combining two medications into one pill.

Exforge

(amlodipine / valsartan)

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telmisartan / amlodipine

 

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Summary for Exforge

Prescription only

Exforge is a combination blood pressure medication for adults. It contains amlodipine (a calcium channel blocker, or CCB) and valsartan (an angiotensin receptor blocker, or ARB). It comes as a tablet that's taken by mouth, typically once per day. Some side effects of Exforge (amlodipine / valsartan) include swelling throughout the body and dizziness. This medication is available as generics.

Indications for Exforge

Pros and Cons for Exforge

Pros

  • Convenient to take a combination of two medications in one pill
  • Only taken once a day
  • Available as a lower-cost generic

Cons

  • Not safe to take while pregnant or breastfeeding
  • Might not be a good choice for people with liver problems
  • Can cause swelling in the arms and legs

Common Side Effects for Exforge

  • Swelling in legs or arms (5%)
  • Sore throat, runny nose, and other cold-like symptoms (3-4%)
  • Dizziness (2%)

Warnings for Exforge

  • Harm to unborn baby
  • Low blood pressure
  • Risk of heart attack or chest pain
  • Possible kidney damage in certain people
  • High potassium levels

Summary for Twynsta

Prescription only

Telmisartan / amlodipine is a combination medication containing an angiotensin II receptor blocker (telmisartan) and a calcium channel blocker (amlodipine). It's used to treat adults with high blood pressure. The typical dosage is to take one tablet by mouth once a day. Common side effects include swelling and dizziness. Although the brand Twynsta has been discontinued, the generic medication is still available.

Indications for Twynsta

  • High blood pressure

Pros and Cons for Twynsta

Pros

  • Contains two first-choice medications for treating high blood pressure
  • Convenient to take a single pill that's a combination of two medications
  • Taken once a day by mouth with or without food
  • Available as a lower-cost generic

Cons

  • Can cause swelling in the arms and legs
  • More difficult to adjust the amount of each individual ingredient in the medication
  • Can interact with other medications
  • Not safe in pregnancy or breastfeeding

Common Side Effects for Twynsta

  • Swelling (5%)
  • Dizziness (3%)
  • Back pain (2%)

Warnings for Twynsta

  • Harm to unborn baby
  • Low blood pressure
  • High potassium levels
  • Risk of heart attack or chest pain
  • Possible kidney damage in certain people

Prices with our coupons for Exforge vs. Twynsta

Price Card Drug Icon
Amlodipine/Valsartan90 tablets / 5mg/160mg
$53.35$281.74
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Price Card Drug Icon
Telmisartan/Amlodipine90 tablets / 40mg/5mg
$123.36$528.45
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