Key takeaways
Ibuprofen / famotidine and naproxen (Aleve, Naprosyn) are both medications used to treat conditions like rheumatoid arthritis and osteoarthritis. They belong to the non-steroidal anti-inflammatory drug (NSAID) class, which helps reduce pain and inflammation. However, ibuprofen / famotidine is a combination medication that also includes famotidine, a histamine H2 antagonist, to help protect against stomach ulcers. Ibuprofen / famotidine is taken as a single tablet three times a day, while naproxen can be taken two to three times a day, depending on the condition being treated. Naproxen is available in both tablet and liquid forms, whereas ibuprofen / famotidine is only available as a tablet. Ibuprofen / famotidine used to be available as brand-name Duexis, but this product was discontinued. Common side effects of ibuprofen / famotidine include headache and nausea, while naproxen can cause heartburn and drowsiness. Both medications can increase the risk of stomach bleeding, especially when taken with other NSAIDs or alcohol. Naproxen is available over-the-counter in lower doses, but ibuprofen / famotidine requires a prescription.
