Key takeaways
Dovato (dolutegravir/lamivudine) and Odefsey (emtricitabine/rilpivirine/tenofovir alafenamide) are both used to treat HIV, but they have some key differences. Dovato combines two antiretrovirals (ARVs) into one pill, while Odefsey combines three ARVs. Dovato is taken once daily and can be taken with or without food, whereas Odefsey must be taken with a meal containing at least 400 calories. Dovato is not recommended for people with severe kidney or liver problems, while Odefsey is safer for your kidneys and bones compared to older treatments like Complera. However, Odefsey has more dietary restrictions. Both medications have interactions with other medications, such as those for tuberculosis and seizures. Both medications can cause side effects like headaches and sleep problems, but Dovato has a higher risk of weight gain and serious allergic reactions.
