Key takeaways
Clozapine (Clozaril) and haloperidol (Haldol) are both used to treat schizophrenia, but they have some key differences. Clozapine is an atypical antipsychotic taken orally and is often reserved for cases where other treatments have failed due to its risk of severe side effects, such as low white blood cell count and seizures. It requires regular blood tests and is part of a special monitoring program. Haloperidol, on the other hand, is a typical antipsychotic given as an injection, either monthly for long-term treatment or as a quick-acting shot for acute agitation. Haloperidol has a higher risk of movement-related side effects but is less likely to cause weight gain compared to clozapine. While clozapine can cause drowsiness and weight gain, haloperidol is less likely to make you sleepy and has a lower risk of weight gain. Both medications carry a risk of serious heart problems and should not be used in older adults with dementia-related psychosis.
