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Cleocin vs. MetroGel-Vaginal

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Cleocin (clindamycin) and Metrogel (metronidazole) are both antibiotics, but they are used for different conditions and come in different forms. Cleocin (clindamycin) is a lincosamide antibiotic used as a vaginal suppository to treat bacterial vaginosis, while Metrogel (metronidazole) is a nitroimidazole antibiotic used topically to treat rosacea, a type of adult acne. Cleocin is only available as a brand-name medication, making it potentially more expensive, whereas Metrogel is available in generic forms, which can be more affordable. Cleocin is typically used once daily for 3 days, whereas Metrogel needs to be applied daily and may take 3-4 weeks to show significant improvement. Cleocin can cause local side effects like vaginal irritation and yeast infections, while Metrogel can cause skin dryness, stinging, and irritation. Additionally, Cleocin should not be used with tampons or during vaginal sex, as it can weaken condoms and diaphragms, whereas Metrogel allows for the use of makeup and moisturizers.

Cleocin

(clindamycin)

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Metrogel

(metronidazole)

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Summary for Cleocin

Prescription only

Cleocin (clindamycin) vaginal ovule is an antibiotic suppository that treats bacterial vaginosis (BV), a type of vaginal infection. This medication can be prescribed for adults or adolescent females who've started their menstrual periods. But it's not approved for people who are pregnant. Cleocin (clindamycin) vaginal suppository is inserted vaginally once daily, typically at bedtime, for 3 days. Side effects aren't common, but can include vaginal discomfort, such as irritation and pain.

Indications for Cleocin

Pros and Cons for Cleocin

Pros

  • Only used once a day
  • Typically only used for 3 days
  • Applicator can be washed and reused for each insertion
  • Can be inserted without using an applicator

Cons

  • Vaginal application can be uncomfortable for some people
  • Might cause vaginal yeast infections
  • Can't use condoms, diaphragms, or tampons during and up to 3 days after treatment
  • Recommended to use at bedtime to prevent medication from leaking

Common Side Effects for Cleocin

Warnings for Cleocin

  • Severe diarrhea
  • Vaginal yeast infections
  • Damage to vaginal contraceptives

Summary for MetroGel-Vaginal

Prescription only

Metrogel (metronidazole) is used on the skin to treat a certain skin disorder known as rosacea, a type of adult acne. It may help to decrease redness, swelling and the number of pimples caused by rosacea.

Indications for MetroGel-Vaginal

  • Adult acne

Pros and Cons for MetroGel-Vaginal

Pros

  • Works well to lower the swelling due to adult acne.
  • It has fewer side effects than oral tablets.
  • It is available as a generic product.
  • There are different strengths of Metrogel (metronidazole) available.
  • Available as a gel, lotion and cream.
  • Can still wear make-up under Metrogel (metronidazole).
  • Can be used in elderly people.

Cons

  • Can cause stinging, dryness, or irritation when applied.
  • It takes about 3-4 weeks to see significant improvement while using this medication.
  • Has to be used daily to see benefits from this medication.
  • Safety has not be studied in children.

Common Side Effects for MetroGel-Vaginal

  • Nasopharyngitis - a common cold that affects the nose and throat (3%)
  • Upper respiratory tract infection - a cold that affects the nose, throat, and lungs (3%)
  • Headache (2%)

Source: DailyMed

Warnings for MetroGel-Vaginal

  • EYE IRRITATION
  • WEAKNESS AND TINGLING SENSATION IN THE HANDS AND FEET
  • SKIN RASH

Prices with our coupons for Cleocin vs. MetroGel-Vaginal

Price Card Drug Icon
Clindamycin30 capsules / 300mg
$16.95-
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Metronidazole1 tube / 45g of 0.75%
$26.98$153.39
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