Key takeaways
Loratadine (Claritin) and acetaminophen/dextromethorphan/phenylephrine (Dayquil Cold and Flu) are both over-the-counter medications, but they have some important differences. Loratadine is an antihistamine used primarily for allergy symptoms like runny nose and itchy eyes, while Dayquil Cold and Flu is a combination medication that includes an analgesic, a cough suppressant, and a decongestant to treat cold and flu symptoms such as cough, sore throat, and fever. Loratadine is typically taken once daily and is available in various forms like tablets and oral solutions, whereas Dayquil Cold and Flu is taken every 4 hours and comes in pills and liquid form. Loratadine is less likely to cause drowsiness compared to other antihistamines, but it can still cause headaches and tiredness. Dayquil Cold and Flu can cause stomach upset and nervousness, and it may affect your sleep due to its decongestant component. You should avoid taking loratadine with other antihistamines and Dayquil Cold and Flu with other medications containing acetaminophen to prevent overdose.
