Key takeaways
Cefpodoxime and cephalexin are both cephalosporin antibiotics used to treat bacterial infections, including urinary tract infections (UTIs) and ear infections. However, they differ in several ways. Cefpodoxime, available as a generic, is typically taken twice a day and is used for a wider range of infections, such as gonorrhea. Cephalexin, also available as a generic, is taken 2 to 4 times a day and is used for infections like bone and reproductive system infections. While both medications can cause side effects like diarrhea and nausea, cephalexin may also cause indigestion and dizziness. Cefpodoxime should be taken with food to improve absorption, whereas cephalexin can be taken with or without food. Both medications can interact with other drugs like probenecid, but cephalexin has specific interactions with metformin. Additionally, cephalexin carries a risk of seizures and bleeding, especially in people with kidney problems or those taking high doses.
