Key takeaways
Captopril (Capoten) and lisinopril (Zestril) are both ACE inhibitor medications used to treat high blood pressure and heart failure. They also help improve survival after a heart attack. However, there are some differences between them. Captopril is taken two to three times a day on an empty stomach, while lisinopril is usually taken once daily and can be taken with or without food. Captopril is only available as a generic tablet, whereas lisinopril is available as both a tablet and an oral solution. Lisinopril can be used in children as young as 6 years old for high blood pressure, but captopril is typically prescribed for adults. Common side effects of both medications include a dry cough and dizziness, but lisinopril may be more likely to cause headaches. Both medications should not be taken with NSAIDs like ibuprofen (Motrin) or naproxen (Aleve). Both medications are also not recommended during pregnancy.
