Key takeaways
Aczone (dapsone) and Differin (adapalene) are both topical treatments for acne, but they work in different ways and belong to different drug classes. Aczone is a sulfone antibiotic that likely reduces acne by killing bacteria and reducing inflammation, while Differin is a retinoid that helps by replacing old skin cells with new ones and unclogging pores. Aczone is available in two strengths and can be applied once or twice a day, whereas Differin is typically applied once daily at bedtime. Differin can be found over-the-counter in its lower strength, while Aczone requires a prescription. Common side effects of Aczone include redness and dryness at the application site, whereas Differin often causes skin irritation, burning, and increased sensitivity to sunlight. Both medications can take several weeks to show full effects, up to 12 weeks.
