Alpha-2 agonist / beta blocker combinations are used to treat conditions like glaucoma and ocular hypertension. These medications work by combining the effects of alpha-2 agonists and beta blockers. The alpha-2 agonist and beta blocker both reduce the production of aqueous humor in the eye. The alpha-2 agonist also helps aqueous humor drain out of the eye. This dual action helps to lower intraocular pressure in the eye. These medications are typically available in eye drop form. An example is brimonidine/timolol (Combigan). You can use these medications to effectively manage your condition as prescribed by a healthcare professional.