The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
The side effects you might experience can differ depending on the type of cancer you have and whether you’re taking Braftovi (encorafenib) with Mektovi (binimetinib) or Erbitux (cetuximab).
- Fatigue (up to 51%)
- Nausea (up to 41%)
- Lower red blood cells (anemia, up to 36%)
- Vomiting (up to 30%)
- Stomach pain (up to 30%)
- Higher liver enzymes in blood (up to 29%)
- Joint pain (up to 27%)
- Lower white blood cell count (up to 24%)
- Muscle pain (up to 23%)
- Constipation (up to 22%)
- Rash (up to 26%)
- Headache (up to 22%)
Less Common Side Effects
- Fever
- Bleeding
- Dry skin
- Thickened skin
- Numbness and tingling in fingers and toes
- Dizziness
- Diarrhea
- Lower appetite
Braftovi serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Bleeding: blood in stool, bleeding from rectum, sudden headache
- Changes in heart rhythm: lightheadedness, fainting, seizures, loss of consciousness
Source: DailyMed
The following Braftovi side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
- Eye pain, redness, irritation, or discharge with blurry or decreased vision
- Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
- Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Redness, swelling, and blistering of the skin over hands and feet
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
