The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
The side effects below were reported by people with melanoma during clinical studies. Side effects might differ for people with Erdheim-Chester disease.
- Joint pain (up to 67%)
- Tiredness (up to 54%)
- Rash (up to 52%)
- Sun sensitivity (up to 49%)
- Hair loss (up to 45%)
- Nausea (up to 37%)
- Itching (up to 30%)
- Skin papilloma (non-cancerous, wart-like skin growth; up to 30%)
- Diarrhea (up to 29%)
- Thickened skin (up to 28%)
- Headache (up to 27%)
- Vomiting (up to 26%)
Less Common Side Effects
- Muscle or back pain
- Pain in arms or legs
- Swelling in arms or legs
- Low appetite
- Constipation
- Fever
- Dry skin
- Sunburn
- Rash
- New skin cancers
- Changes in taste
- Cough
- Weakness
- Changes in liver enzyme levels in blood
Zelboraf serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reactions: rash, fever, trouble breathing, swelling of the face or mouth
- Serious skin reactions: painful blisters, skin wounds, peeling skin
- Serious liver problems: upper stomach pain, yellow skin, yellow around the whites of the eyes
- Changes in heart rhythm: lightheadedness, blurry vision, fainting, seizures, loss of consciousness
- Serious reaction in people who’ve received radiation therapy: see Warnings for more details
Source: DailyMed
The following Zelboraf side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Blistering, peeling, or loosening of the skin
bloating or swelling of the face, arms, hands, lower legs, or feet
bloody urine
blurred vision or other change in vision
chills
decreased frequency or amount of urine
dizziness
fainting
fast or irregular heartbeat
increased sensitivity of the skin to sunlight
increased thirst
itching or skin rash
joint or muscle pain
loss of appetite
lower back or side pain
lump or growth on the skin
pain in the ankles or knees
painful, red lumps under the skin, mostly on the legs
paralysis of the nerves
rapid weight gain
rash with flat lesions or small raised lesions on the skin
red skin lesions, often with a purple center
red, irritated eyes
redness or other discoloration of the skin
redness, soreness, swelling, or itching of the skin
scaling of the skin on the hands and feet
sensitivity of the eye to light
severe sunburn
sores, ulcers, or white spots in the mouth or on the lips
sores, welts, or blisters
tearing
tingling of the hands and feet
tiredness
trouble breathing
ulceration of the skin
unusual tiredness or weakness
unusual weight gain or loss
vomiting
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Back or bone pain
burning, itching, and pain in the hairy areas, or pus at the root of the hair
change in taste
decreased appetite
decreased weight
difficulty having a bowel movement
difficulty with moving
hair loss or thinning of the hair
headache
lack or loss of strength
loss of taste
muscle stiffness
pain in the arms or legs
sunburn
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
