The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
The following side effects were reported in adults taking Tafinlar (dabrafenib). Side effects might differ depending on the cancer you have and in children.
- High blood sugar (up to 71%)
- Higher liver enzymes in the blood (up to 64%)
- Fever (up to 63%)
- Tiredness (up to 59%)
- Changes in other blood test results (up to 57%)
- Rash (up to 42%)
- Nausea (up to 45%)
- Headache (up to 39%)
- Chills (up to 37%)
- Diarrhea (up to 33%)
- Vomiting (up to 33%)
- Cough (up to 29%)
- Muscle or joint pain (up to 28%)
- Constipation (up to 27%)
Less Common Side Effects
- Skin thickening
- Dry skin
- Rash on hands and feet
- Papilloma (non-cancerous, wart-like skin growth)
- Lower appetite
- Swelling in legs
- Bleeding
- Hair loss
- Trouble breathing
Tafinlar serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Bleeding: nosebleed, blood in stool, sudden and severe headache
- Serious eye problems: sudden and severe eye pain, sudden vision loss
- Serious skin reactions: painful blisters, skin wounds, peeling skin, fever, muscle aches
- Serious blood problems: fever, severe tiredness, weakness, trouble breathing
Source: DailyMed
The following Tafinlar side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Bleeding gums
bloody or cloudy urine
blurred vision
coughing up blood
difficulty in breathing or swallowing
dizziness
flushed, dry skin
fruit-like breath odor
greatly decreased frequency of urination or amount of urine
headache
increased hunger
increased thirst
increased urination
lump or growth on the skin
nosebleed
prolonged bleeding from cuts
red or black, tarry stools
red or dark brown urine
redness, swelling, or pain of the skin
scaling of the skin on the hands and feet
skin blisters
skin rash
stomach pain
sweating
swelling of the feet or lower legs
tingling of the hands and feet
ulceration of the skin
unable to move
unexplained weight loss
unusual tiredness or weakness
vomiting
Less common
Blurred vision or other change in vision
change in color vision
difficulty seeing at night
increased sensitivity of the eyes to sunlight
redness of the eye
tearing
Incidence not known
Blistering, peeling, loosening of the skin
chills
joint or muscle pain
red skin lesions, often with a purple center
sores, ulcers, or white spots in the mouth or on lips
swollen, painful, or tender lymph glands in the neck, armpit, or groin
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Back pain
difficulty having a bowel movement
fast heartbeat
hair loss or thinning of the hair
headache
indigestion
loss of appetite
muscle ache or stiffness
pains in the stomach, side, or abdomen, possibly radiating to the back
stuffy or runny nose
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
