FDA Approves First Liquid Spironolactone

Roni Shye
Roni Shye, PharmD BCGP BCACP, is a licensed pharmacist in the states of Florida, Ohio, and Pennsylvania.
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Currently, spironolactone is only available in tablet form, which is not an option for those who have difficulty swallowing pills. In order to make this drug more accessible to all, the FDA approved CaroSpir, the 1st liquid version of spironolactone.    

What is CaroSpir indicated for?

CaroSpir is for the treatment of heart failure, high blood pressure, and water retention (edema) in certain patient populations.

How is CaroSpir sold?

CaroSpir is available as a liquid suspension in a 118 ml bottle with a strength of 25 mg/5 ml. It is banana flavored and can be stored at room temperature.

Before the approval of CaroSpir, what did patients do?

Before the approval of CaroSpir, if a patient needed liquid spironolactone the medication would need to be compounded.  The compounding pharmacy would crush up spironolactone tablets and place them into a suspension formula typically using water for irrigation or propylene glycol and cherry flavored syrup.  

The main disadvantage to compounded spironolactone liquid is dosing inconsistency which has been a persistent challenge for physicians.   

How much will CaroSpir cost?

At the moment, patients can use a GoodRx Coupon and get CaroSpir for around $1000. Not cheap.

However, there is a way to make it more affordable! CaroSpir has a prescription savings program called the EasyPay Program so patients can lower the out-of-pocket costs associated with a CaroSpir prescription. Patients can save up to $75 on each prescription using their EasyPay Card.

For more information, see the CaroSpir website here.

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