Androderm (testosterone patch) is a testosterone replacement therapy that acts like the natural sex hormone testosterone. It raises testosterone levels in adult males who are diagnosed with low testosterone, also known as hypogonadism. Androderm (testosterone patch) is a patch that's applied to your skin once a day. Some common effects of this medication include skin irritation, itching, and burning.
Please note: Androderm (testosterone patch) has been discontinued and is no longer available in the United States. Talk to your primary care provider about alternative testosterone replacement therapies available to treat low testosterone.
Low testosterone levels in adult males (hypogonadism)
Androderm (testosterone patch) is a testosterone replacement therapy that acts like the natural sex hormone, testosterone. Testosterone is responsible for the development and maintenance of many male features and functions, such as muscle and bone strength and growth, and regulating sex drive and sperm production.
Androderm (testosterone patch) works by raising testosterone to normal and healthy levels in males with low testosterone.
Androderm (testosterone patch) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: History of heart conditions
Testosterone replacement therapy can raise your red blood cell (RBC) count. This is thought to raise the risk of blood clots, including strokes and heart attacks. But more information is needed to understand whether there is a link. Your prescriber will order blood tests before you start Androderm (testosterone patch) and every 3 to 6 months to check if your RBC count is within a safe range. If your RBC level is too high, they might ask you to stop Androderm (testosterone patch) until it becomes lower.
In addition, Androderm (testosterone patch) itself might be linked to a higher risk of heart attack, stroke, or sudden cardiac (heart-related) death. Get emergency help right away if you have chest pain, cold sweats, left arm pain, difficulty breathing, trouble walking, trouble speaking, or weakness on one side of the body, since you might have to stop taking the medication.
There have been reports of Androderm (testosterone patch) causing blood clots in your legs or lungs. Symptoms of a blood clot in the legs include leg pain, swelling, or redness. Symptoms of a blood clot in the lungs include difficulty breathing or chest pain. Let your prescriber know if you have any of these symptoms and seek medical help right away as you might have to stop the medication.
Risk factors: Taking more Androderm (testosterone patch) than prescribed | Taking Androderm (testosterone patch) with other testosterones
Androderm (testosterone patch) is a controlled substance, because it has a risk of misuse and addiction, especially if you use higher doses than prescribed or use it with other testosterones. Only take Androderm (testosterone patch) as prescribed to lower the risk of misuse, dependency, and addiction.
Risk factors: History of enlarged prostate
Taking Androderm (testosterone patch) can worsen certain symptoms in people with an enlarged prostate, or benign prostatic hyperplasia (BPH). Let your prescriber know if you experience any changes in your urinary routine, such as more urination at night, feeling like you need to urinate more often or immediately, trouble urinating, accidentally urinating, or urinating slowly.
Androderm (testosterone patch) can raise your risk of prostate cancer. Your prescriber might have you perform occasional blood tests and physical check-ups before and during treatment with Androderm (testosterone patch) . Androderm (testosterone patch) isn't recommended if you have prostate cancer because it can worsen your cancer.
Using certain forms of testosterone, such as methyltestosterone and testosterone enanthate intramuscular injection, for long periods of time can cause life-threatening liver problems. This isn't a known risk of Androderm (testosterone patch) but it's important to look out for signs and symptoms of liver damage. Let your care team know if you're experiencing stomach pain, light-colored stools, dark urine, or if your skin or the whites of your eyes turn yellow because you might need to stop the medication.
*Risk factors: Higher doses of Androderm (testosterone patch) *
Androderm (testosterone patch) can lower sperm count, which might affect your ability to have a baby (fertility). There's a chance these effects can be permanent. Let your prescriber know if you're thinking of having a baby before you start Androderm (testosterone patch) .
Risk factors: History of heart, liver, or kidney conditions | Taking other medications that cause swelling like corticosteroids
Androderm (testosterone patch) can cause your body to hold onto more salt and water, which can lead to swelling in your legs or arms and sudden weight gain. This is more likely to happen if you're taking other medications that cause swelling, such as corticosteroids (e.g., prednisone, methylprednisolone (Medrol)). It can be more serious in people with heart, liver, or kidney conditions. Talk to your prescriber if you have any of these symptoms because you might need to stop the medication.
Risk factors: History of sleep apnea | Identified as obese | History of lung disease
Androderm (testosterone patch) can worsen symptoms in people who have breathing problems in their sleep. This is called sleep apnea. This is more likely to happen to people who also have a history of obesity or lung disease, like asthma or chronic obstructive pulmonary disease (COPD). If you experience more daytime sleepiness or if your partner notices that you stop breathing in your sleep more often, talk to your prescriber.
Risk factors: History of cancer | Taking other medications that cause high calcium in the blood
Androderm (testosterone patch) can cause high calcium in the blood (hypercalcemia), especially in people with cancer or people who take medications that raise calcium. High calcium levels can lead to muscle weakness and kidney problems, such as frequent urination, thirst, stomach pain, and blood in the urine. During treatment with Androderm (testosterone patch) , your prescriber might have you perform regular blood tests to make sure your calcium levels are within the normal range.
Source: DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Skin itching, blistering, or redness at the application site
Less common
Blistering, burning, crusting, dryness, or flaking of the skin
bloody or black, tarry stools
burning feeling at the application site
difficult urination
hardening or thickening of the skin under patch
itching, scaling, severe redness, soreness, or swelling of the skin
pelvic pain
severe stomach pain
vomiting of blood or material that looks like coffee grounds
Rare
Bladder pain
bloody or cloudy urine
blurred vision
difficult, burning, or painful urination
dizziness
frequent urge to urinate
headache
lower back or side pain
nervousness
pounding in the ears
slow or fast heartbeat
testicular problems
Incidence not known
Pain, redness, or swelling in the arm or leg
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Discouragement
feeling sad or empty
irritability
lack of appetite
loss of interest or pleasure
rash
tiredness
trouble concentrating
trouble sleeping
Rare
Accelerated growth
blemishes on the skin
body pain
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
cold hands and feet
contamination of the application site
decreased interest in sexual intercourse
fear
feeling of constant movement of self or surroundings
inability to have or keep an erection
increased appetite
lightheadedness
loss in sexual ability, desire, drive, or performance
loss of bladder control
mood or mental changes
sensation of spinning
thinking abnormalities
weakness
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Compared to testosterone gel, there’s a lower risk of accidentally exposing others to testosterone
Doesn't need to be removed during sex or while showering or bathing
Applied to your skin
Applied once a day
Can cause skin irritation
Need to remember to rotate application sites every night
Heavy exercise or sweating too much might cause the patch to loosen or fall off
Need to wait 3 hours before you can shower, swim, or bathe
Mark your appointments in your calendar to see your healthcare professional (HCP) and get any needed blood tests done while taking Androderm (testosterone patch) . The test results can let your HCP know whether they need to adjust your dose of Androderm (testosterone patch) .
Testosterone replacement therapy like Androderm (testosterone patch) can cause growth, pain, or tenderness in the breast area of males. This might continue throughout treatment. Let your HCP know if this becomes bothersome.
Testosterone replacement therapy like Androderm (testosterone patch) can lower your blood sugar levels. People with diabetes might need to monitor their blood sugar more often while taking this medication. If needed, your HCP might adjust the dose of your blood sugar medications.
Taking testosterone replacement therapy like Androderm (testosterone patch) together with blood thinners like warfarin (Coumadin) might cause you to bleed more easily. Your HCP might monitor your blood clotting time more often while taking this medication. Let your care team know if you experience bleeding that takes longer to stop, bruising, blood in your urine, or dark stools because your dose might need to be adjusted.
Adults: The typical starting dose is one 4 mg patch applied every night to your back, stomach, upper arms, or thighs. Your prescriber might adjust your dose depending on how your testosterone levels respond to the medication.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Males with breast cancer or prostate cancer
Currently pregnant
Low testosterone levels in adult males (hypogonadism)
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Allergan, Inc. (2020). Androderm- testosterone patch [package insert]. DailyMed.
American Society of Health-System Pharmacists. (2023). Testosterone transdermal system.
Drugs@FDA: FDA-Approved Drugs. (n.d.). Androderm. U.S. Food and Drug Administration.
Saad, F., et al. (2011). Onset of effects of testosterone treatment and time span until maximum effects are achieved. European Journal of Endocrinology.
Sizar, O., et al. (2024). Male hypogonadism. StatPearls.
You and Your Hormones. (2020). Testosterone.
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