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Androderm

testosterone patch
Used for Testosterone Replacement
Used for Testosterone Replacement

Androderm (testosterone patch) is a testosterone replacement therapy that acts like the natural sex hormone testosterone. It raises testosterone levels in adult males who are diagnosed with low testosterone, also known as hypogonadism. Androderm (testosterone patch) is a patch that's applied to your skin once a day. Some common effects of this medication include skin irritation, itching, and burning.

Please note: Androderm (testosterone patch) has been discontinued and is no longer available in the United States. Talk to your primary care provider about alternative testosterone replacement therapies available to treat low testosterone.

Last reviewed on May 20, 2024
Androderm (testosterone patch) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Androderm (testosterone patch) ?

What is Androderm (testosterone patch) used for?

How Androderm (testosterone patch) works

Androderm (testosterone patch) is a testosterone replacement therapy that acts like the natural sex hormone, testosterone. Testosterone is responsible for the development and maintenance of many male features and functions, such as muscle and bone strength and growth, and regulating sex drive and sperm production.

Androderm (testosterone patch) works by raising testosterone to normal and healthy levels in males with low testosterone.

Are you looking for information on testosterone gel (Androgel) instead?
When does Androderm (testosterone patch) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsAndroderm
Drug ClassTestosterone replacement
Controlled Substance ClassificationSchedule III
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
warings-icon

What are the risks and warnings for Androderm (testosterone patch) ?

Androderm (testosterone patch) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Higher red blood cell count and high risk of heart attack or stroke

  • Risk factors: History of heart conditions

    Testosterone replacement therapy can raise your red blood cell (RBC) count. This is thought to raise the risk of blood clots, including strokes and heart attacks. But more information is needed to understand whether there is a link. Your prescriber will order blood tests before you start Androderm (testosterone patch) and every 3 to 6 months to check if your RBC count is within a safe range. If your RBC level is too high, they might ask you to stop Androderm (testosterone patch) until it becomes lower.

    In addition, Androderm (testosterone patch) itself might be linked to a higher risk of heart attack, stroke, or sudden cardiac (heart-related) death. Get emergency help right away if you have chest pain, cold sweats, left arm pain, difficulty breathing, trouble walking, trouble speaking, or weakness on one side of the body, since you might have to stop taking the medication.

    risk-warning

    Blood clots

    There have been reports of Androderm (testosterone patch) causing blood clots in your legs or lungs. Symptoms of a blood clot in the legs include leg pain, swelling, or redness. Symptoms of a blood clot in the lungs include difficulty breathing or chest pain. Let your prescriber know if you have any of these symptoms and seek medical help right away as you might have to stop the medication.

    risk-warning

    Potential for misuse, dependency, and addiction

    • Risk factors: Taking more Androderm (testosterone patch) than prescribed | Taking Androderm (testosterone patch) with other testosterones

      Androderm (testosterone patch) is a controlled substance, because it has a risk of misuse and addiction, especially if you use higher doses than prescribed or use it with other testosterones. Only take Androderm (testosterone patch) as prescribed to lower the risk of misuse, dependency, and addiction.

      risk-warning

      Worsening symptoms of enlarged prostate and prostate cancer

      • Risk factors: History of enlarged prostate

        Taking Androderm (testosterone patch) can worsen certain symptoms in people with an enlarged prostate, or benign prostatic hyperplasia (BPH). Let your prescriber know if you experience any changes in your urinary routine, such as more urination at night, feeling like you need to urinate more often or immediately, trouble urinating, accidentally urinating, or urinating slowly.

        Androderm (testosterone patch) can raise your risk of prostate cancer. Your prescriber might have you perform occasional blood tests and physical check-ups before and during treatment with Androderm (testosterone patch) . Androderm (testosterone patch) isn't recommended if you have prostate cancer because it can worsen your cancer.

        risk-warning

        Liver problems

        Using certain forms of testosterone, such as methyltestosterone and testosterone enanthate intramuscular injection, for long periods of time can cause life-threatening liver problems. This isn't a known risk of Androderm (testosterone patch) but it's important to look out for signs and symptoms of liver damage. Let your care team know if you're experiencing stomach pain, light-colored stools, dark urine, or if your skin or the whites of your eyes turn yellow because you might need to stop the medication.

        risk-warning

        Low sperm count

        • *Risk factors: Higher doses of Androderm (testosterone patch) *

          Androderm (testosterone patch) can lower sperm count, which might affect your ability to have a baby (fertility). There's a chance these effects can be permanent. Let your prescriber know if you're thinking of having a baby before you start Androderm (testosterone patch) .

          risk-warning

          Swelling in the legs or arms (edema)

          • Risk factors: History of heart, liver, or kidney conditions | Taking other medications that cause swelling like corticosteroids

            Androderm (testosterone patch) can cause your body to hold onto more salt and water, which can lead to swelling in your legs or arms and sudden weight gain. This is more likely to happen if you're taking other medications that cause swelling, such as corticosteroids (e.g., prednisone, methylprednisolone (Medrol)). It can be more serious in people with heart, liver, or kidney conditions. Talk to your prescriber if you have any of these symptoms because you might need to stop the medication.

            risk-warning

            Breathing problems during sleep (sleep apnea)

            • Risk factors: History of sleep apnea | Identified as obese | History of lung disease

              Androderm (testosterone patch) can worsen symptoms in people who have breathing problems in their sleep. This is called sleep apnea. This is more likely to happen to people who also have a history of obesity or lung disease, like asthma or chronic obstructive pulmonary disease (COPD). If you experience more daytime sleepiness or if your partner notices that you stop breathing in your sleep more often, talk to your prescriber.

              risk-warning

              High calcium in the blood

              • Risk factors: History of cancer | Taking other medications that cause high calcium in the blood

                Androderm (testosterone patch) can cause high calcium in the blood (hypercalcemia), especially in people with cancer or people who take medications that raise calcium. High calcium levels can lead to muscle weakness and kidney problems, such as frequent urination, thirst, stomach pain, and blood in the urine. During treatment with Androderm (testosterone patch) , your prescriber might have you perform regular blood tests to make sure your calcium levels are within the normal range.

                basics-icon

                What are the side effects of Androderm (testosterone patch) ?

                The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

                Common Side Effects

                • Application site itchiness (17%)
                • Application site blisters (6%)
                • Back pain (6%)

                Other Side Effects

                • Application site redness
                • Chills
                • Diarrhea
                • Fatigue
                • Headache
                • Acid reflux
                • Bleeding into a joint
                • Blood in the urine
                • Urinating more
                • Swelling of the prostate

                Serious Side Effects

                Contact your healthcare provider immediately if you experience any of the following.
                • Heart attack: chest pain, cold sweats, left arm pain, difficulty breathing
                • Stroke: face drooping, trouble seeing, walking, or speaking, weakness on one side of the body
                • Blood clots: legs (pain, swelling, warm to touch, redness), lungs (trouble breathing, chest pain, cough)
                • Withdrawal: depression, fatigue, craving, restlessness, irritability, lack of appetite, trouble sleeping (insomnia), lower sex drive, low testosterone
                • Liver damage: stomach pain, nausea, vomiting, yellowing of the skin, yellowing of the whites of the eyes, light-colored stools, dark urine, weight loss
                When do Androderm (testosterone patch) possible side effects begin and end?
                Time passed since treatment started:
                HOURS
                DAYS
                WEEKS
                MONTHS
                Application site irritation

                Source: DailyMed

                The following side effects have also been reported

                Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

                Check with your doctor immediately if any of the following side effects occur:

                More common

                Skin itching, blistering, or redness at the application site

                Less common

                Blistering, burning, crusting, dryness, or flaking of the skin

                bloody or black, tarry stools

                burning feeling at the application site

                constipation

                difficult urination

                hardening or thickening of the skin under patch

                itching, scaling, severe redness, soreness, or swelling of the skin

                pelvic pain

                severe stomach pain

                vomiting of blood or material that looks like coffee grounds

                Rare

                Bladder pain

                bloody or cloudy urine

                blurred vision

                difficult, burning, or painful urination

                dizziness

                frequent urge to urinate

                headache

                lower back or side pain

                nervousness

                pounding in the ears

                slow or fast heartbeat

                testicular problems

                Incidence not known

                Pain, redness, or swelling in the arm or leg

                Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

                Less common

                Discouragement

                feeling sad or empty

                irritability

                lack of appetite

                loss of interest or pleasure

                rash

                tiredness

                trouble concentrating

                trouble sleeping

                Rare

                Accelerated growth

                blemishes on the skin

                body pain

                burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

                cold hands and feet

                contamination of the application site

                decreased interest in sexual intercourse

                fear

                feeling of constant movement of self or surroundings

                inability to have or keep an erection

                increased appetite

                lightheadedness

                loss in sexual ability, desire, drive, or performance

                loss of bladder control

                mood or mental changes

                pimples

                sensation of spinning

                thinking abnormalities

                weakness

                Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

                Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

                pros-and-cons

                Pros and cons of Androderm (testosterone patch)

                thumbs-up

                Pros

                Compared to testosterone gel, there’s a lower risk of accidentally exposing others to testosterone

                Doesn't need to be removed during sex or while showering or bathing

                Applied to your skin

                Applied once a day

                thumbs-down

                Cons

                Can cause skin irritation

                Need to remember to rotate application sites every night

                Heavy exercise or sweating too much might cause the patch to loosen or fall off

                Need to wait 3 hours before you can shower, swim, or bathe

                pharmacist-tips

                Pharmacist tips for Androderm (testosterone patch)

                pharmacist
                • Mark your appointments in your calendar to see your healthcare professional (HCP) and get any needed blood tests done while taking Androderm (testosterone patch) . The test results can let your HCP know whether they need to adjust your dose of Androderm (testosterone patch) .

                  • Testosterone replacement therapy like Androderm (testosterone patch) can cause growth, pain, or tenderness in the breast area of males. This might continue throughout treatment. Let your HCP know if this becomes bothersome.

                    • Testosterone replacement therapy like Androderm (testosterone patch) can lower your blood sugar levels. People with diabetes might need to monitor their blood sugar more often while taking this medication. If needed, your HCP might adjust the dose of your blood sugar medications.

                      • Taking testosterone replacement therapy like Androderm (testosterone patch) together with blood thinners like warfarin (Coumadin) might cause you to bleed more easily. Your HCP might monitor your blood clotting time more often while taking this medication. Let your care team know if you experience bleeding that takes longer to stop, bruising, blood in your urine, or dark stools because your dose might need to be adjusted.

                        faqs

                        Frequently asked questions about Androderm (testosterone patch)

                        Is Androderm (testosterone patch) discontinued?
                        Yes, Androderm (testosterone patch) is discontinued and is no longer available in the United States. But there are several other testosterone replacement therapies that your healthcare professional (HCP) might recommend in place of Androderm (testosterone patch) .
                        Is Androderm (testosterone patch) a controlled substance?
                        Yes, Androderm (testosterone patch) is a schedule III controlled substance because it has a risk of addiction and dependence.
                        How well does Androderm (testosterone patch) work?
                        Studies show almost 100% of people achieved normal testosterone levels after using Androderm (testosterone patch) for 28 days.
                        How long does it take for Androderm (testosterone patch) to work?
                        Studies show that males who took Androderm (testosterone patch) saw their testosterone levels return to normal within 28 days of starting treatment. But the time it takes to feel the effects of normal testosterone levels will depend on the specific effect. For example, a study showed it can take about 3 weeks for sexual interest to appear, but can take up to 6 months to notice changes in erections/ejaculation. Additionally, it can take up to a year to see more controlled blood sugar levels and more stabilized muscle strength. Your prescriber will monitor you closely to see how you're responding to testosterone replacement therapy and adjust your dose if needed. Talk to your prescriber if you're concerned with how well Androderm (testosterone patch) is working for you.
                        Where do I apply Androderm (testosterone patch) ?
                        Androderm (testosterone patch) is applied to clean, dry, and unbroken skin on the back, abdomen, upper arms, or thighs. Because it can cause skin irritation, a new patch needs to be applied to a different site on your body every night. Wait at least 7 days before applying it to the same spot. Don't apply Androderm (testosterone patch) to skin that's oily, sweaty, or hairy because the patch might not stick as well. Avoid applying it to your scrotum, buttocks, or over a bony area. Please note Androderm (testosterone patch) has been discontinued. Talk to your primary care provider about using other testosterone replacement therapies.
                        How long do you wear Androderm (testosterone patch) ?
                        Androderm (testosterone patch) is applied all day. A patch should be worn for up to 24 hours and then replaced with a new patch. Once you've applied the patch to a particular location on the skin, don't apply to that same area for at least 7 days. This will help prevent skin irritation and side effects. Please note Androderm (testosterone patch) has been discontinued. Talk to your primary care provider about using other testosterone replacement therapies.
                        How do you prevent Androderm (testosterone patch) rash?
                        Talk to your prescriber or your pharmacist if you experience any rash or irritation. Androderm (testosterone patch) is known to cause skin irritation at the application site, itching, and rash. A healthcare professional might recommend using an over-the-counter (OTC) steroid cream, such as hydrocortisone, after the patch is removed.
                        What's the difference between Androderm and Androgel?
                        Both Androderm and Androgel are brands that contain testosterone as the active ingredient. Androgel is supplied as a gel that's applied to the shoulders or upper arm, whereas Androderm (testosterone patch) is a patch that's applied to the skin all day. Secondly, Androgel is still available in the market whereas Androderm has been discontinued.
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                        dosage

                        Androderm (testosterone patch) dosage forms

                        Typical dosing for Androderm (testosterone patch)

                        • Adults: The typical starting dose is one 4 mg patch applied every night to your back, stomach, upper arms, or thighs. Your prescriber might adjust your dose depending on how your testosterone levels respond to the medication.

                        interactions

                        Interactions between Androderm (testosterone patch) and other drugs

                        Androderm (testosterone patch) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Androderm (testosterone patch) . Please note that only the generic name of each medication is listed below.

                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        • Licorice
                        contraindications-icon

                        Androderm (testosterone patch) contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Androderm (testosterone patch) will not be safe for you to take.
                        • Males with breast cancer or prostate cancer

                        • Currently pregnant

                        alternatives

                        What are alternatives to Androderm (testosterone patch) ?

                        There are a number of medications that your doctor can prescribe in place of Androderm (testosterone patch) . Compare a few possible alternatives below.
                        Androderm (testosterone patch)
                        Used for:
                        Used for:
                        • Low testosterone (hypogonadism)

                        $38.30 Lowest GoodRx priceView Prices
                        Used for:
                        $554.89 Lowest GoodRx priceView Prices

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                        References

                        Best studies we found

                        Allergan, Inc. (2020). Androderm- testosterone patch [package insert]. DailyMed.

                        American Society of Health-System Pharmacists. (2023). Testosterone transdermal system.

                        Drugs@FDA: FDA-Approved Drugs. (n.d.). Androderm. U.S. Food and Drug Administration.

                        View All References (3)

                        Saad, F., et al. (2011). Onset of effects of testosterone treatment and time span until maximum effects are achieved. European Journal of Endocrinology.

                        Sizar, O., et al. (2024). Male hypogonadism. StatPearls.

                        You and Your Hormones. (2020). Testosterone.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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