The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Abnormal liver labs (up to 91%)
- Diarrhea (up to 86%)
- Low red blood cell levels (84%)
- Nausea (up to 80%)
- Abnormal kidney labs (up to 77%)
- Vomiting (up to 67%)
- Stomach pain (up to 54%)
- Higher blood sugar levels (up to 53%)
- Tiredness (up to 52%)
- Lower phosphate levels (up to 38%)
- Abnormal pancreas labs (up to 37%)
- Loss of appetite (up to 34%)
Less Common Side Effects
- Constipation
- Cough
- Weight loss
- Rash
- Chest pain
- Back pain
- Headache
- Fever
- Heartburn, stomach reflux, or trouble swallowing
Zykadia serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious heart rhythm problems: blurry vision, feeling light-headed, weakness, pounding heart
- Lung problems: cough, fever, trouble breathing, shortness of breath, chest pain
- Pancreas problems: upper stomach or back that gets worse when you eat, unexplained weight loss, nausea, or vomiting
- Liver problems: nausea, vomiting stomach pain or swelling, itchy skin, dark-colored urine, pale-colored stool, yellowing of the whites of the eyes or skin
- Severe stomach problems: diarrhea, nausea, vomiting, or stomach pain
Source: DailyMed
The following Zykadia side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dry cough, shortness of breath or trouble breathing
- Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
- High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
- Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Diarrhea
- Fatigue
- Loss of appetite with weight loss
- Nausea
- Stomach pain
- Vomiting
