Drugs for Men: A GoodRx Savings Guide to 7 Notable Men’s Health Medications
Viagra and minoxidil are some of the most commonly prescribed medications for men. See the other top drugs for men’s health, from ED treatment to hair loss.
Xyosted
Used for Testosterone Replacement
Used for Testosterone Replacement
Xyosted (testosterone enanthate) is a testosterone replacement therapy used to treat adult males with low testosterone. It comes as a prefilled autoinjector that you inject under the skin in the stomach once a week. Side effects include high blood pressure, headache, and bruising at the injection site.
What is Xyosted (testosterone enanthate)?
What is Xyosted (testosterone enanthate) used for?
- Low testosterone (also called hypogonadism)
How Xyosted (testosterone enanthate) works
Xyosted (testosterone enanthate) is a testosterone replacement therapy that acts like the natural hormone testosterone. Testosterone helps support many male traits and functions, such as muscle and bone strength, sex drive, and sperm production.
Xyosted (testosterone enanthate) works by raising testosterone levels back to a normal and healthy range in males with low testosterone.
When does Xyosted (testosterone enanthate) start working?Time passed since treatment started:
Drug facts
| Common Brands | Xyosted |
|---|---|
| Drug Class | Testosterone replacement |
| Controlled Substance Classification | Schedule III |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Risks and warnings for Xyosted (testosterone enanthate)
Xyosted (testosterone enanthate) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Higher red blood cell count
Xyosted (testosterone enanthate) can raise your red blood cell count, which can lead to blood clots. Your prescriber will check your red blood cell levels before you start treatment and during it. If your levels get too high, you might have to stop the medication until they go back to normal.
Blood clots
Xyosted (testosterone enanthate) itself can cause life-threatening blood clots in your legs or lungs. If you notice leg pain, swelling, warmth, or redness, tell your prescriber right away, as these could be signs of a blood clot in your leg. If you suddenly have trouble breathing or chest pain, it could mean a clot has moved to your lungs. If this happens, you might have to stop taking the medication.
Worsening of enlarged prostate and risk of prostate cancer
- Risk factors: History of enlarged prostate
Taking Xyosted (testosterone enanthate) can worsen certain symptoms if you have an enlarged prostate, also called benign prostatic hyperplasia (BPH). Let your prescriber know if you notice changes in urination, such as going more often at night, feeling like you need to go right away, having trouble starting, leaking, or a weak stream.
Xyosted (testosterone enanthate) might also raise your risk of prostate cancer. Your prescriber might order blood tests or check your prostate before and during treatment to help keep you safe.
Higher blood pressure
- Risk factors: History of high blood pressure
Xyosted (testosterone enanthate) can raise your blood pressure. Having high blood pressure over time can raise your risk for heart problems, like heart attack or stroke.
Get emergency help right away if you have chest pain, cold sweats, left arm pain, trouble breathing, trouble walking, trouble speaking, or weakness on one side of the body. You should check your blood pressure often while you’re using this medication, especially if you already have high blood pressure.
Potential for misuse, addiction, and dependency
- Risk factors: Taking more Xyosted (testosterone enanthate) than prescribed | Taking Xyosted (testosterone enanthate) with other testosterones
Xyosted (testosterone enanthate) is a controlled substance because it can be misused or cause dependence, especially if you take higher doses than prescribed or combine it with other testosterone products.
Misusing Xyosted (testosterone enanthate) can lead to addiction. This medication is only approved by the FDA to treat low testosterone in men. Taking Xyosted (testosterone enanthate) for other reasons can cause serious heart and mental health problems. Always use it exactly as prescribed.
Lower sperm count
- Risk factors: Taking more Xyosted (testosterone enanthate) than prescribed
Xyosted (testosterone enanthate) can lower sperm count, which might make it harder to have a baby. This is more likely with higher doses, and the effect could be permanent. Tell your prescriber if you plan to have children before starting this medication.
Liver problems
Using certain forms of testosterone, such as methyltestosterone or testosterone enanthate intramuscular injection, for a long time can cause serious liver problems. This isn't a known risk of Xyosted (testosterone enanthate), but it's still important to look out for symptoms of liver damage. Let your prescriber know if you have stomach pain, pale stools, dark urine, or yellowing of your skin or eyes.
Swelling in the arms and legs (edema)
- Risk factors: History of heart, liver, or kidney conditions | Taking other medications that cause swelling like corticosteroids
Xyosted (testosterone enanthate) can make your body keep extra salt and water, which might lead to edema, or swelling in your arms and legs. This is more likely if you take other medications that cause swelling, like corticosteroids (e.g., prednisone, methylprednisolone). Swelling can be more serious if you have heart, liver, or kidney problems. Tell your prescriber if you notice these symptoms.
Breathing problems during sleep (sleep apnea)
- Risk factors: Obesity | History of lung problems
Xyosted (testosterone enanthate) can make sleep apnea, a condition that causes breathing problems during sleep, worse in some people. This is more likely if you have obesity or lung problems. Talk to your prescriber if you or your partner notice loud snoring, pauses in breathing during sleep, or if you feel very tired during the day.
Enlarged breasts
Some people using Xyosted (testosterone enanthate) might develop gynecomastia, which is swelling or enlargement of breast tissue in men. You might also feel soreness or pain in your chest area. Talk to your prescriber if you have questions about this side effect.
Changes in cholesterol levels
Testosterone treatments like Xyosted (testosterone enanthate) can affect your cholesterol levels. Your prescriber might need to adjust your dose or stop the medication if these changes happen. They will check your cholesterol regularly, especially when you first start using the medication.
High calcium levels
- Risk factors: History of cancer
Xyosted (testosterone enanthate) can raise calcium levels in your blood and urine, especially in people with cancer. High calcium levels can cause symptoms such as muscle weakness, frequent urination, thirst, stomach pain, and blood in the urine. Your prescriber might check your blood regularly during treatment to make sure your calcium levels stay normal.
Mood changes and thoughts suicide
- Risk factors: History of depression | History of mental health conditions
Xyosted (testosterone enanthate) can affect your mood. Some people have reported depression, anxiety, or thoughts of self-harm while taking this medication.
Tell your care team right away if you notice new or worsening depression, anxiety, mood changes, or thoughts of hurting yourself. Family members and caregivers should also watch for these changes and seek medical help if they occur.
Side effects of Xyosted (testosterone enanthate)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- High red blood cell count (14%)
- High blood pressure (13%)
- Rise in prostate-specific antigen (PSA, (12%)
- Injection site bruising (7%)
- Headache (5%)
Less Common Side Effects
- Back pain
- Injection site bleeding
- Acne
- Cough
- Swelling in the arms and legs
- Injection site redness
- Urinary tract infection
- Stomach pain
- Joint pain
- Tiredness
- Blood in the urine
- Sleep apnea problems
Xyosted (testosterone enanthate) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- High blood pressure: headache, dizziness, blurred vision, shortness of breath, chest pain, nosebleeds, pounding heartbeat
- Heart attack: chest pain, cold sweats, left arm pain, difficulty breathing
- Stroke: face drooping, trouble seeing, walking, or speaking, weakness on one side of the body
- Blood clot in the legs: pain, swelling, warm to touch, redness
- Blood clot in the lungs: trouble breathing, chest pain, cough
- Liver damage: stomach pain, nausea, vomiting, yellowing of the skin, yellowing of the whites of the eyes, light-colored stools, dark urine, weight loss
- Withdrawal: depression, fatigue, craving, restlessness, irritability, lack of appetite, trouble sleeping, lowered sex drive, low testosterone
- Suicidal thoughts and behaviors
When do Xyosted (testosterone enanthate) possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
High red blood cell count
Rise in PSA
Injection site reactions
High blood pressure
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.
The following Xyosted (testosterone enanthate) side effects have also been reported
Discuss these possible effects with your doctor:
Tumors of the liver, liver cancer, or peliosis hepatis (a form of liver disease) have occurred during long-term, high-dose therapy with androgens. Although these effects are rare, they can be very serious and may cause death.
Androgens can stimulate existing prostate cancer in men who already have it but have not yet been diagnosed. Also, the prostate (a male gland) may become enlarged. Enlargement of the prostate does not mean that cancer will develop. If enlargement occurs and you have difficulty in urinating, it is a good idea to be checked by your doctor.
When androgens are used in women, especially in high doses, male-like changes may occur, such as hoarseness or deepening of the voice, unnatural hair growth, or unusual hair loss. Most of these changes will go away if the medicine is stopped as soon as the changes are noticed. However, some changes, such as voice changes or enlarged clitoris, may not go away.
When androgens are used in high doses in males, they interfere with the production of sperm. This effect is usually temporary and only happens during the time you are taking the medicine. However, discuss this possible effect with your doctor if you are planning on having children.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
For females only
Acne or oily skin
decreased breast size
irregular menstrual cycles
hoarseness or deepening of voice
increase in size of female genitals
increase in unnatural hair growth or male pattern baldness
These symptoms may occur in females whose male sexual partner uses a scrotal patch.
For males only
Blistering of skin under patch (especially when the nonscrotal patch is applied to bony areas of the skin)
breast soreness or enlargement
frequent or continuing erection of penis lasting up to 4 hours or painful penile erections lasting longer than 4 hours
frequent urge to urinate
itching or redness of skin under patch (less likely with nonscrotal patch) or at site of implants, mild to severe
For prepubertal boys only
early growth of pubic hair
enlargement of penis
frequent or continuing erections
Less common
For males or females
Dizziness
frequent or continuing headache
lack or loss of strength
overall body flushing, redness, or itching of skin
rapidly changing moods, such as depersonalization, dysphoria, euphoria, depression, paranoia, and quick to react or overreact emotionally
swelling of feet or lower legs
unusual bleeding
unusual tiredness
yellow skin or eyes (occurring with fluoxymesterone or methyltestosterone more often than with testosterone)
For females with breast cancer or bedridden males or females—in addition to the side effects listed above
Confusion or mental depression
increased thirst
increased urge to urinate or increased amount of urine
For males only
Black, tarry stools
burning sensation or hardening or thickening of skin under patch
chills
continuing pain at site of implants
difficulty in urinating
itching, skin redness, or rash under patch, severe (less likely with nonscrotal patch)
pain in scrotum or groin
vomiting of blood or material that looks like coffee grounds
Rare
For males or females—more likely with oral androgens or long-term or high doses of androgens
Abdominal or stomach pain, continuing
bad breath odor, continuing
black, tarry or light-colored stools or dark urine
loss of appetite, continuing
mood or mental changes
purple or red spots on body or inside the mouth or nose
swelling, pain, or tenderness of abdomen
vomiting of blood
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
For males and females
Acne, mild
decrease or increase in sexual desire or drive
hair loss or thinning of hair
increase in pubic hair growth
infection, pain, redness, or other irritation at site of injection
nervousness
stomach pain
trouble in sleeping
For males only
Decrease in testicle size
infection, pain, redness, swelling, sores, or other skin irritation underneath patch
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
N/A
GoodRx discount
$165.23
Pros and cons of Xyosted (testosterone enanthate)
Pros
- Only needs to be injected once a week
- Available as a ready-to-use autoinjector
- Can be injected at home
Cons
- Can cause high blood pressure
- Requires regular blood tests to monitor testosterone
- Not approved for children
Pharmacist tips for Xyosted (testosterone enanthate)
- Check your blood pressure regularly while taking Xyosted (testosterone enanthate). This medication can raise your blood pressure, which might increase your risk of heart attack or stroke.
- Xyosted (testosterone enanthate) can cause breast swelling, tenderness, or pain. Tell your prescriber if these symptoms become bothersome.
- Xyosted (testosterone enanthate) can lower your blood sugar. If you have diabetes, you might need to check your blood sugar more often. Know how to treat low blood sugar.
- If you take warfarin, you might need more frequent INR blood tests when starting, stopping it, or changing your dose of Xyosted (testosterone enanthate). Testosterones can increase your risk of bleeding.
- Xyosted (testosterone enanthate) can lower your sperm count and may affect your ability to have children. Talk to your care team before starting treatment if you plan to have a baby in the future.
- Storage: Keep Xyosted (testosterone enanthate) at room temperature. Don't refrigerate or freeze it, and keep it in the original box until you’re ready to use it.
How to use Xyosted (testosterone enanthate)
- Read the instructions for use before your first injection. Ask your prescriber or pharmacist if you have questions about how to inject it.
- When you're ready to inject, use your fingers to gently pinch an area of your stomach, and keep pinching until you finish injecting. With your other hand, press the injector firmly against the skin until you hear a click, then hold it in place for 10 seconds.
- Rotate injection sites each week to help reduce bruising and skin irritation.
- After injecting, throw away the injector in a sharps container to avoid injury. Follow local instructions for safe disposal.
Xyosted (testosterone enanthate) dosage
The average cost for 1 carton of 4 autoinjectors of 75mg of Xyosted (testosterone enanthate) is $437.21 with a free GoodRx coupon. This is 45.05% off the average retail price of $795.67.
Interactions between Xyosted (testosterone enanthate) and other drugs
Xyosted (testosterone enanthate) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Xyosted (testosterone enanthate). Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acenocoumarol
- Anisindione
- Atorvastatin
- Bupropion
- Dicumarol
- Fluvastatin
- Lovastatin
- Paclitaxel
- Paclitaxel Protein-Bound
- Pexidartinib
- Phenindione
- Phenprocoumon
- Warfarin
How much does Xyosted (testosterone enanthate) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Xyosted (brand)
$165.23
Xyosted (testosterone enanthate) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Xyosted (testosterone enanthate) will not be safe for you to take.
- Men with breast cancer or prostate cancer
- Women who are pregnant
What are alternatives to Xyosted (testosterone enanthate)?
There are a number of medications that your doctor can prescribe in place of Xyosted (testosterone enanthate). Compare a few possible alternatives below.
News about Xyosted (testosterone enanthate)
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Xyosted (testosterone enanthate) images
