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Xtampza ER Coupon - Xtampza ER 9mg capsule

Xtampza ER

oxycodone
Used for Pain
Used for Pain

Xtampza ER is an extended-release form of oxycodone and it's an opioid medication. It's used in adults to treat long-term pain that isn't relieved by non-opioid pain medications. Xtampza ER (oxycodone) is a capsule that's taken by mouth every 12 hours. Xtampza ER (oxycodone) is available as a brand-name medication only; there's no lower-cost generic yet. Common side effects include nausea, headache, and constipation. Xtampza ER (oxycodone) is a controlled substance because it has a warning for misuse and dependence.

Last reviewed on June 12, 2024
Xtampza ER (oxycodone) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Xtampza ER (oxycodone)?

What is Xtampza ER (oxycodone) used for?

How Xtampza ER (oxycodone) works

Xtampza ER (oxycodone) is an opioid. It attaches to certain mu-opioid receptors in your brain to lower how much pain you feel.

When does Xtampza ER (oxycodone) start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsXtampza ER
Drug ClassOpioid
Controlled Substance ClassificationSchedule II
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$487.09(save 18.06%)
GoodRx discount
$399.11
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What are the risks and warnings for Xtampza ER (oxycodone)?

Xtampza ER (oxycodone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Potential for addiction and misuse

  • Risk factors: Personal or family history of alcohol or substance use disorder | Personal or family history of mental health problems

    Xtampza ER (oxycodone) is a controlled substance that has a risk for misuse and addiction. Take the medication exactly as prescribed. Don't change how much or how often you take it without talking to your prescriber first.

    Misusing Xtampza ER (oxycodone) can raise the risk for serious and possibly life-threatening side effects, such as dangerously slow breathing, not able to stay awake, addiction, and opioid overdose. You'll be prescribed the lowest amount of Xtampza ER (oxycodone) that's necessary to manage your pain for the shortest period of time possible.

    Because of the risk for misuse and addiction, Xtampza ER (oxycodone) is only available through a Risk Evaluation and Mitigation Strategy (REMS) program called the Opioid Analgesic REMS program. Your prescriber and pharmacy must register with the program, receive training on proper medication use, and discuss with you about how to safely take Xtampza ER (oxycodone).

    risk-warning

    Dangerously slow breathing (respiratory depression)

    • Risk factors: Taking medications that can cause slow breathing | Drinking alcohol | Older age | Being frail | Medical conditions that cause breathing problems (e.g., COPD, asthma, head injury) | Taking too much Xtampza ER (oxycodone)

      Xtampza ER (oxycodone) can cause dangerously slow breathing, which can be life-threatening. This can happen to anyone and at recommended doses. But the risk is greatest when you first start treatment or when your prescriber raises your dose.

      Don't drink alcohol while you're taking Xtampza ER (oxycodone). Also don't take Xtampza ER (oxycodone) with medications that slow your body down (e.g., benzodiazepines, other opioids, muscle relaxants). This can put you at risk for having dangerously slow breathing.

      Your prescriber will recommend that you have naloxone (Narcan) to carry with you at all times. Naloxone is a medication that can reverse slowed breathing from opioids. Use naloxone, call 911, and get medical help right away if you or your loved one notices that you have trouble breathing or have bluish-colored lips, fingers, or toes.

      risk-warning

      Risk for opioid overdose

      • Risk factors: History of opioid use disorder | Previous opioid overdose | Taking high doses of Xtampza ER (oxycodone) | Taking more opioids than prescribed | Alcohol use

        Take Xtampza ER (oxycodone) exactly as prescribed. Taking too much medication or taking it more often than prescribed can lead to an overdose. It can be very dangerous if someone accidentally swallows the medication. Be sure to keep Xtampza ER (oxycodone) out of reach from children, pets, and visitors to prevent accidental exposure or overdose.

        Symptoms of an opioid overdose include not responding to sound or touch, extremely slow breathing, slow heartbeat, extreme sleepiness, and cold or clammy skin. Be sure you and your loved ones know how to recognize an overdose. Your prescriber will recommend getting naloxone (Narcan) — either by prescription or over the counter. Naloxone can help treat an opioid overdose. Carry naloxone with you at all times; use it and call 911 right away if an overdose happens.

        risk-warning

        Difficulty concentrating and extreme sleepiness

        • Risk factors: Taking high doses of Xtampza ER (oxycodone) | Age 65 years or older | Drinking alcohol | Taking other medications that can cause sleepiness

          Xtampza ER (oxycodone) can cause extreme sleepiness and lower your ability to think, react, and focus. Don't drink alcohol with Xtampza ER (oxycodone). Also don't take Xtampza ER (oxycodone) with other medications that can cause sleepiness or "brain fog" (e.g., benzodiazepines, muscle relaxants, sleep medications). Otherwise, these side effects might worsen.

          Make sure you know how Xtampza ER (oxycodone) affects you before driving a car or doing activities that require your concentration. Talk to your prescriber right away if you feel too sleepy from the medication.

          risk-warning

          Drug interactions

          Xtampza ER (oxycodone) interacts with several medications. Let your care team know what medications you're taking to make sure they're safe for you to take together. Also speak with your care team first before making any changes to your medications because sudden dose adjustments can be harmful.

          Some medications can raise the level of Xtampza ER (oxycodone) in your body, which can raise your risk for serious side effects like potentially life-threatening slowed breathing. Medications that can lead to this type of interaction include erythromycin and ritonavir (Norvir), among others.

          Other interactions, such as with rifampin (Rifadin) or carbamazepine (Tegretol), can lower the levels of Xtampza ER (oxycodone) in your body. This can cause the opioid medication to work less well to manage your pain. These interactions might also lead to withdrawal symptoms.

          risk-warning

          Harm to newborn babies

          Long-term use of Xtampza ER (oxycodone) during pregnancy can cause your unborn baby to become dependent on the medication. This is because Xtampza ER (oxycodone) can pass through the placenta to your unborn baby.

          Once your baby is born, they can experience withdrawal symptoms, such as high-pitched crying, poor feeding behavior, trembling, abnormal sleep patterns, and even seizures. This condition is called neonatal opioid withdrawal syndrome and can be life-threatening if not recognized and treated in time. Let your healthcare professional (HCP) know if you've taken Xtampza ER (oxycodone) during pregnancy or if you notice these symptoms in your baby.

          risk-warning

          Physical dependence and withdrawal

          • Risk factors: Long-term use of Xtampza ER (oxycodone)

            If taken regularly for a long time, Xtampza ER (oxycodone) can cause physical dependence. This means that your body relies on the medication to function. And you might experience withdrawal if you lower your dose too quickly or suddenly stop taking the medication. Withdrawal symptoms include anxiety, restlessness, irritability, runny nose, yawning, sweating, and chills.

            Don't suddenly lower your dose or stop taking Xtampza ER (oxycodone) suddenly without talking to your prescriber first. If needed, your prescriber will slowly lower your dose over time to prevent withdrawal symptoms. Talk to an HCP if you have concerns about taking Xtampza ER (oxycodone) because of the risk for withdrawal.

            risk-warning

            Low blood pressure

            Xtampza ER (oxycodone) can cause extremely low blood pressure. For example, your blood pressure might suddenly drop when you stand from a sitting or lying down position. This can lead to dizziness and fainting. To avoid falling, get up slowly if you've been sitting or lying down. Talk to an HCP if dizziness or lightheadedness doesn't go away.

            risk-warning

            Low adrenal hormone levels

            • Risk factors: Taking Xtampza ER (oxycodone) for longer than 1 month

              Some people taking opioids like Xtampza ER (oxycodone) have had low adrenal hormone levels. This can be more likely to happen after taking opioids for longer than 1 month. Tell your HCP if you have symptoms of low adrenal hormone levels, such as tiredness, dizziness, weakness, not feeling hungry, nausea, and vomiting. If your adrenal hormone levels are too low, you might need to stop Xtampza ER (oxycodone) and get treated with corticosteroids.

              risk-warning

              Seizures

              • Risk factors: History of seizure conditions

                If you've had a seizure in the past, Xtampza ER (oxycodone) can raise the risk of having seizures more often. Opioids can also raise your risk of seizures in certain situations. Get medical help immediately if you have a seizure while you're taking Xtampza ER (oxycodone).

                basics-icon

                What are the side effects of Xtampza ER (oxycodone)?

                The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

                Common Side Effects

                • Nausea (17%)
                • Headache (14%)
                • Constipation (13%)
                • Sleepiness (9%)
                • Itching (7%)
                • Vomiting (6%)
                • Dizziness (6%)

                Other Side Effects

                • Blurry vision
                • Stomach pain
                • Low appetite
                • Rash

                Serious Side Effects

                Contact your healthcare provider immediately if you experience any of the following.
                • Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
                • Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, slow heartbeat, extreme sleepiness, cold or clammy skin
                • Opioid withdrawal: anxiety, suicidal thoughts, restlessness, irritability, runny nose, yawning, sweating, chills, wide pupils
                • Serious allergic reaction: itchy, red rash (hives); shortness of breath; chest tightness; swelling of lips, tongue, throat, face, or eyes
                When do Xtampza ER (oxycodone) possible side effects begin and end?
                Time passed since treatment started:
                MINUTES
                HOURS
                DAYS
                WEEKS
                MONTHS
                Sleepiness
                "Brain fog"
                Nausea or vomiting
                Constipation
                Risk for dangerously slowed breathing
                Seek immediate medical care if you experience this side effect.
                If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

                Source: DailyMed

                The following side effects have also been reported

                Side effects that you should report to your care team as soon as possible:

                • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
                • CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, difficulty staying awake
                • Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
                • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision

                Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

                pros-and-cons

                Pros and cons of Xtampza ER (oxycodone)

                thumbs-up

                Pros

                Might help with long-term pain that's not completely relieved with non-opioid pain relievers

                Continues to relieve pain for up to 12 hours after a dose

                Can open the capsules and sprinkle contents onto soft food or into an empty cup for people who can't swallow capsules whole

                thumbs-down

                Cons

                Taken every 12 hours

                Not meant to be used to treat sudden pain because it takes 1 hour to start working

                Must slowly lower the dose to stop the medication after long-term use to avoid withdrawal symptoms

                pharmacist-tips

                Pharmacist tips for Xtampza ER (oxycodone)

                pharmacist
                • Take Xtampza ER (oxycodone) with food, about the same amount each time so that the medication levels in your body stay consistent. Taking Xtampza ER (oxycodone) on an empty stomach causes your body to absorb less medication, which might make it work less well to relieve your pain.

                  • You can open the Xtampza ER capsule if you're having trouble swallowing them whole. Sprinkle all the contents over one tablespoon of soft food (e.g., applesauce, yogurt, ice cream) or into an empty cup. Then, swallow all the capsule contents right away. Rinse your mouth with water to make sure you've taken your full dose. Flush the empty capsule down the toilet to throw it away.

                    • Take Xtampza ER (oxycodone) exactly as your prescriber instructed you to. Don't change your dose or stop taking the medication without talking to your prescriber first. They might need to slowly lower your dose before you can stop taking it completely. This lowers your risk of having uncomfortable withdrawal symptoms like sweating, chills, irritability, anxiety, and trouble sleeping.

                      • Xtampza ER (oxycodone) can make you sleepy and affect your ability to think, react, and focus. Don't drive or do anything that you need to focus for until you know how this medication affects you.

                        • Don't drink alcohol while you're taking Xtampza ER (oxycodone). Mixing them together can make you very sleepy or dizzy.

                          • Constipation is a common side effect of Xtampza ER (oxycodone). Some lifestyle changes, like staying hydrated throughout the day and getting more fiber into your diet, might help with this side effect. But speak to your care team if you're still getting constipated. They can suggest medications or a change in your pain treatment to help.

                            • Always carry naloxone (Narcan) with you at all times. Naloxone is a medication that reverses the effects of Xtampza ER (oxycodone) in situations like an accidental overdose. Teach your loved ones about how to give naloxone to you if you can't do it yourself. Be sure to call for emergency help if you need to use naloxone because its effects are temporary.

                              • Keep Xtampza ER (oxycodone) out of reach from children, pets, and visitors. There are a few drug take-back options to safely get rid of the medication if you don't need to take it anymore. This lessens the risk for accidental overdose and medication misuse.

                                More on Xtampza ER (oxycodone) tips

                                faqs

                                Frequently asked questions about Xtampza ER (oxycodone)

                                Is Xtampza ER (oxycodone) an opioid?
                                Yes. Xtampza ER (oxycodone) is an opioid pain medication. In general, opioids have many safety warnings. So be sure to discuss with your prescriber about the risks of opioid use and whether it's an appropriate treatment option for you.
                                How long does it take Xtampza ER (oxycodone) to work?
                                It takes about 1 hour to start feeling pain relief from Xtampza ER (oxycodone). Since it takes some time to start working, Xtampza ER (oxycodone) is taken on a schedule (every 12 hours), rather than as needed, for pain.
                                Can you take ibuprofen or Tylenol with Xtampza ER (oxycodone)?
                                Yes, you can take ibuprofen (Advil) or acetaminophen (Tylenol) with Xtampza ER (oxycodone). They're both generally safe to take with Xtampza ER (oxycodone) because they don't interact with the opioid medication. In fact, clinical guidelines for pain recommend taking non-opioid pain medications, such as ibuprofen and acetaminophen, if you need more relief while you're taking Xtampza ER (oxycodone). This helps lessen the amount of opioids you need to take for pain and the dangerous risks that come with opioids. Keep in mind that these non-opioid pain medications can also have their own risks, such as heart, kidney, or liver problems. Before you take other pain relievers with Xtampza ER (oxycodone), check with your healthcare team to make sure it's safe for you to do so.
                                Can you crush Xtampza ER (oxycodone) capsules?
                                No, you can't crush the Xtampza ER (oxycodone) capsules because this might damage the medication. If you're having trouble swallowing the capsules whole, you can open them and sprinkle the contents onto a small amount of soft food (e.g., applesauce, pudding, yogurt, ice cream, jam) and then eat it right away. Or you can sprinkle the contents into an empty cup, pour the contents from the cup into the mouth, and then swallow. Afterwards, rinse your mouth with water to make sure you've swallowed any medication that's still in the mouth.
                                Is Xtampza ER the same as oxycodone?
                                Xtampza ER is a brand-name medication that contains oxycodone as the active ingredient. More specifically, Xtampza ER is an extended-release form of oxycodone; the Xtampza ER capsule releases the medication slowly into the body. This helps control pain throughout the day. There are other forms of oxycodone: immediate-release oxycodone (Roxicodone, Oxaydo) and another brand-name extended-release oxycodone called OxyContin.
                                Is Xtampza ER the same as OxyContin?
                                No, but they're very similar. Xtampza ER and OxyContin are both extended-release forms of oxycodone, meaning that they slowly release the medication into the body throughout the day. The main difference is that OxyContin is a tablet and Xtampza ER is a capsule. You can't cut, crush, or chew either; this can cause too much medication to get into the body too quickly and raise your risk for serious side effects. But you can open the Xtampza ER capsule and sprinkle the contents over soft food or into an empty cup and then swallow; this can be an option for people who can't swallow pills whole. Talk to your prescriber if you have questions about comparing between OxyContin and Xtampza ER.
                                Can you take Xtampza ER (oxycodone) if you're pregnant?
                                Xtampza ER (oxycodone) is generally not recommended during pregnancy because of the risk of harm to an unborn baby. Let your prescriber know if you're pregnant or thinking of becoming pregnant. Your prescriber can discuss with you about safer options for relieving pain while you're pregnant.
                                Can you take Xtampza ER (oxycodone) while breastfeeding?
                                It's typically recommended to avoid taking Xtampza ER (oxycodone) while you're breastfeeding. Opioids like oxycodone can get into breast milk. This can raise the risk for your breastfed baby to have serious side effects like sleepiness and slow breathing. Tell your care team if you're breastfeeding or thinking of starting to breastfeed. They can discuss with you about safer options for treating pain or for feeding your baby.
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                                dosage

                                Xtampza ER (oxycodone) dosage forms

                                The average cost for 60 capsules of 9mg of Xtampza ER (oxycodone) is $399.11 with a free GoodRx coupon. This is 18.06% off the average retail price of $487.09.
                                capsule
                                Capsule
                                DosageQuantityPrice as low asPrice per unit
                                9mg60 capsules$399.11$6.65
                                13.5mg60 capsules$577.86$9.63
                                18mg60 capsules$755.42$12.59
                                27mg60 capsules$1016.24$16.94
                                36mg60 capsules$1208.75$20.15

                                Typical dosing for Xtampza ER (oxycodone)

                                Your prescriber will work with you to find the right dose for your individual needs. It's recommended to take the lowest dose possible for the shortest duration of time to manage your pain.

                                The typical starting dose is 9 mg by mouth every 12 hours with food.

                                Your dose might differ if you have liver problems.

                                drug-cost

                                How much does Xtampza ER (oxycodone) cost?

                                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                                contraindications-icon

                                Xtampza ER (oxycodone) contraindications

                                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Xtampza ER (oxycodone) will not be safe for you to take.
                                • Severely slowed breathing (respiratory depression)

                                • Severe asthma

                                • Conditions that cause blockage of the stomach passageway

                                • Allergy to oxycodone

                                images

                                Xtampza ER (oxycodone) images

                                White Xtampza Er 9 Mg - Xtampza 9mg Extended-Release Capsule
                                This medicine is White Capsule Imprinted With "Xtampza Er 9 Mg".White Xtampza Er 9 Mg - Xtampza 9mg Extended-Release Capsule

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                                References

                                Best studies we found

                                American College of Obstetricians and Gynecologists. (2017). Opioid use and opioid use disorder in pregnancy.

                                American College of Obstetricians and Gynecologists. (2021). Breastfeeding challenges: ACOG committee opinion, number 820. Obstetrics & Gynecology.

                                Anesthesia Patient Safety Foundation. (n.d.). Respiratory depression and opioids.

                                View All References (10)

                                Center for Disease Control and Prevention. (2024). About opioid use during pregnancy.

                                Collegium Pharmaceutical, Inc. (2023). Xtampza ER- oxycodone capsule, extended release [package insert]. DailyMed.

                                Dowell, D., et al. (2022). CDC clinical practice guideline for prescribing opioids for pain — United States, 2022. Morbidity and Mortality Weekly Report.

                                Drugs and Lactation Database (LactMed®). (2024). Oxycodone. National Institute of Child Health and Human Development.

                                Jansson, L. M., et al. (2019). Neonatal abstinence syndrome. Pediatric Clinics of North America.

                                McNicol, E., et al. (2003). Management of opioid side effects in cancer-related and chronic noncancer pain: A systematic review. The Journal of Pain.

                                National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Adrenal insufficiency & Addison’s disease.

                                National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Symptoms & causes of adrenal insufficiency & Addison's disease.

                                Sadiq, N. M., et al. (2024). Oxycodone. StatPearls.

                                U.S. Food and Drug Administration. (2022). Drug disposal: Drug take back locations.

                                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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