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Pazopanib Coupon - Pazopanib 200mg tablet

pazopanib

Generic Votrient
Used for Soft Tissue Sarcoma, Renal Cancer
Used for Soft Tissue Sarcoma, Renal Cancer

Votrient (pazopanib) is a targeted anticancer medication that’s used to treat advanced kidney cancer (renal cell carcinoma) and advanced soft tissue sarcoma in adults. This medication is conveniently taken by mouth once a day. But it can commonly cause side effects like diarrhea, high blood pressure, and changes in hair color (lighter or grayer).

Last reviewed on November 6, 2023
basics-icon

What is Votrient (pazopanib)?

What is Votrient (pazopanib) used for?

  • Advanced kidney cancer (renal cell carcinoma)

  • Advanced soft tissue sarcoma, after previously receiving chemotherapy

How Votrient (pazopanib) works

Votrient (pazopanib) is a targeted therapy for cancer known as a tyrosine kinase inhibitor (TKI). It targets and blocks specific proteins in cancer cells called tyrosine kinases, including those in the VEGFR family, among others. These proteins are involved in providing blood supply to the tumor.

By blocking these tyrosine kinases, Votrient (pazopanib) prevents blood vessels from forming and supplying blood to the tumor. This helps slow and stop cancer growth.

Drug Facts

Common BrandsVotrient
Drug ClassTyrosine kinase inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Votrient (pazopanib)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Elevated liver enzymes (53%)
  • Diarrhea (52%)
  • Elevated blood sugar (41%)
  • High blood pressure (40%)
  • Changes in hair color (e.g., lighter hair color; 38%)
  • Low white blood cell levels (up to 37%)
  • Elevated bilirubin levels (36%)
  • Low platelet levels (32%)
  • Nausea (26%)
  • Loss of appetite or not feeling hungry (22%)
  • Vomiting (21%)
  • Fatigue (19%)
  • Low blood sugar (17%)

Other Side Effects

  • Weakness
  • Headache
  • Taste changes
  • Indigestion
  • Belly pain
  • Chest pain
  • Hoarseness
  • Hair loss
  • Rash
  • Hand-foot syndrome
  • Changes in skin color (e.g., lighter skin color)
  • Weight loss
  • Protein in the urine (cloudy urine)
Note: Side effects listed here were reported by people with renal cell carcinoma during clinical studies. Side effects might differ for people with soft tissue sarcoma.

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious infections: body aches, chills, fever, headache, new cough, sore throat, tiredness
  • Serious heart problems: chest pounding, chest pain, irregular heartbeat, shortness of breath, lightheadedness, swelling in the legs
  • Gut problems: fever; chills; intense stomach pain or cramps; bloating; skin irritation, swelling, or redness around the anus; discharge from the anus; blood in stool
  • Serious liver problems: right-sided stomach pain, tiredness, loss of appetite, yellowing of the skin or eyes
  • Serious bleeding: unusual bleeding, bleeding that’s hard to stop, easy bruising, blood in urine or stool
  • Blood clot in the lungs or serious lung problems: cough, chest pain, trouble breathing, shortness of breath, racing heart
  • Blood clot near the heart: chest pain, stomach discomfort, sweating, nausea, dizziness
  • Blood clot in the leg: leg cramp, swelling, pain, muscle tightness
  • Dangerously high blood pressure: anxiety, blurry vision, confusion, chest pain, nausea, vomiting, headache
  • Tumor lysis syndrome: fever, chills, nausea or vomiting, confusion, shortness of breath, seizures, irregular heartbeat, dark or cloudy urine, muscle or joint pain, unusual tiredness

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Black, tarry stools

bleeding gums

blood in the urine or stools

blurred vision

chest pain

chills

clay colored stools

cloudy urine

constipation

cough

coughing up blood

dark urine

decreased appetite

depressed mood

difficulty with breathing or swallowing

dizziness

dry skin and hair

feeling cold

fever

hair loss

headache

hoarseness or husky voice

increased menstrual flow or vaginal bleeding

itching, skin rash

loss of appetite

lower back or side pain

muscle cramps and stiffness

nausea and vomiting

nervousness

nosebleeds

painful or difficult urination

pale skin

paralysis

pinpoint red spots on the skin

pounding in the ears

prolonged bleeding from cuts

red or black, tarry stools

red or dark brown urine

redness, swelling, or pain of the skin

scaling of the skin on the hands and feet

slow or fast heartbeat

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stomach pain or tenderness

swelling of the feet or lower legs

swollen glands

tingling of the hands and feet

ulceration of the skin

unusual bleeding or bruising

unusual tiredness or weakness

weight gain

yellow eyes or skin

Less common

Bleeding from the rectum or bloody stools

bloody nose

chest discomfort

confusion

fainting

irregular or slow heart rate

numbness or tingling in the face, arms, or legs

pain or discomfort in the shoulders, arms, jaw, back, or neck

sweating

swelling or puffiness of the face

trouble speaking, thinking, or walking

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Change in hair color

change in taste

decreased weight

diarrhea

hair loss

lack or loss of strength

loss of taste

thinning of the hair

weight loss

Less common

Belching

heartburn

indigestion

stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Votrient (pazopanib)

thumbs-up

Pros

Pills that are swallowed once daily

More precise in the way it targets cancer cells than traditional chemotherapy

Recommended treatment option for certain types of kidney cancer and soft tissue sarcoma

thumbs-down

Cons

Shouldn’t take with food (must take at least 1 hour before or 2 hours after a meal)

Has many risks, including infection, bleeding, and blood clots

Not safe to take while pregnant or breastfeeding

pharmacist-tips

Pharmacist tips for Votrient (pazopanib)

pharmacist
  • Take Votrient (pazopanib) once a day without food, at least 1 hour before or 2 hours after a meal. For each dose, you'll need to take several tablets all at once (or one right after another).

    • Swallow Votrient (pazopanib) tablets whole with water. Don't crush, break, or chew tablets because this might affect how well and how quickly the medication is absorbed into the body.

      • If you miss a dose of Votrient (pazopanib), take it as soon as you remember. But if your next dose is less than 12 hours away, don’t take the medication until your next regularly scheduled time. Don't double the dose because this can raise your risk for side effects.

        • Regularly check your blood pressure while you’re taking Votrient (pazopanib) because the medication can raise your blood pressure. Tell your provider if your blood pressure is higher than usual. Your provider can prescribe blood pressure medications to help lower your blood pressure to a safer range.

          • Call your provider if you fall or get injured while you’re taking Votrient (pazopanib). The medication can raise your risk for bleeding, so your provider should check for any serious bleeding to be safe. Also, tell your provider if you notice bruises that don’t go away or bleeding that’s hard to stop because you might need more medical attention.

            • Be sure to tell your provider about any upcoming surgeries or procedures because Votrient (pazopanib) can make it harder for your body to heal from them. Your provider will typically ask you not to take the medication a week before and at least 2 weeks after your procedure and until the wounds fully heal.

              • Sometimes, Votrient (pazopanib) can make urine look cloudy. This can mean that too much protein has passed into your urine, which can be a sign of kidney problems. Tell your provider if you have cloudy-looking urine. You might need lab tests done to check your kidneys.

                • Let your provider and pharmacist know about other medications and supplements you take because Votrient (pazopanib) can interact with many medications. For example, taking the cancer medication with simvastatin (Zocor) can raise your risk for liver damage. Your providers can make sure all your medications are safe for you.

                  • If you or your partner can have children, use reliable birth control methods while you’re taking Votrient (pazopanib) to avoid getting pregnant. After you take your last dose of medication, continue to use birth control for at least 2 weeks. Tell your provider right away if you or your partner gets pregnant while you’re taking this medication. Votrient (pazopanib) can harm an unborn baby.

                    faqs

                    Frequently asked questions about Votrient (pazopanib)

                    Is Votrient (pazopanib) a type of chemotherapy?
                    No, Votrient (pazopanib) isn’t considered chemotherapy. Chemotherapy is a class of medications that directly kills cancer cells that are quickly multiplying in your body. But Votrient (pazopanib) is a type of targeted therapy called a tyrosine kinase inhibitor, which works differently than chemotherapy. Votrient (pazopanib) works by targeting and blocking specific proteins on cancer cells called tyrosine kinases, such as VEGF, PDGF, and FGF, among others. These proteins play a role in providing blood supply to the tumor and promoting tumor growth. By targeting and blocking these specific proteins, Votrient (pazopanib) can help slow cancer growth.
                    Can Votrient (pazopanib) cause changes to my hair?
                    Yes, Votrient (pazopanib) can cause changes in hair color. More specifically, the medication can cause your hair to gradually become lighter in color or gray over a few months. In a study for metastatic kidney cancer, changes in hair color happened in 38% of people who took Votrient (pazopanib). Some people have also reported that their hair texture changed from coarse to fine during treatment. These hair changes might gradually improve when you stop treatment, but it can be permanent in some cases. Speak with your healthcare team if you’re concerned about any changes in hair color or texture that you have while you’re taking Votrient (pazopanib).
                    How can I lower my chances of developing an infection while taking Votrient (pazopanib)?
                    Washing your hands often is one of the best ways to prevent infection while you're taking Votrient (pazopanib). Try to avoid large crowds and people who are sick. In addition, wash raw fruits and vegetables before eating and cook foods thoroughly. It’s important to avoid getting sick while you’re taking Votrient (pazopanib) because the medication can cause your white blood cell counts to drop. Having low levels of white blood cells can weaken your immune system and put you at risk of developing a serious infection. Let your healthcare provider know if you have signs of an infection, like fever, tiredness, or chills.
                    Can I take Votrient (pazopanib) if I have liver problems?
                    Possibly, it depends on how severe your liver problem is. You should be able to take Votrient (pazopanib) if you have mild liver problems. But your healthcare provider might consider an alternative treatment for your cancer or suggest lowering your Votrient (pazopanib) dosage to 200 mg once daily if you have moderate liver problems. And if you have severe liver problems, taking Votrient (pazopanib) isn’t recommended. Speak with your provider before you start treatment if you have liver problems.
                    Can I breastfeed while I’m taking Votrient (pazopanib)?
                    It isn’t recommended to breastfeed while you’re taking Votrient (pazopanib). We don’t know if the medication can pass into human breast milk, but there’s a risk of serious harm to nursing infants if it does. Because of this risk, you shouldn’t breastfeed while you’re taking Votrient (pazopanib) and for at least 2 weeks after your last dose. Talk with your provider about other ways to feed your baby during treatment.
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                    warings-icon

                    What are the risks and warnings for Votrient (pazopanib)?

                    Votrient (pazopanib) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                    risk-warning

                    Serious liver problems

                    • Risk factors: Age greater than 65 years |Taking simvastatin (Zocor)

                      Votrient (pazopanib) can cause liver damage that can sometimes lead to life-threatening liver failure. Your risk for liver damage is higher if you take the cholesterol medication simvastatin (Zocor) with Votrient (pazopanib).

                      In studies, signs of liver damage appeared in the first 4 months of treatment. Your provider will check your liver through lab work at the start of treatment and regularly while you’re taking this medication. Tell your provider if you have symptoms of liver problems, such as tiredness, loss of appetite, nausea or vomiting, dark urine, right-side stomach pain, or yellowing of the eyes or skin. Your provider might check your liver more frequently, pause treatment until your symptoms get better, lower your dose, or stop the medication altogether.

                      risk-warning

                      Heart problems

                      • Risk factors: History of QT prolongation | Taking antiarrhythmics or other medications that can cause QT prolongation | Already have heart problems | Previous treatment with medications like doxorubicin

                        Some people taking Votrient (pazopanib) had heart problems, like a lowering of the heart’s ability to pump blood and heart failure. Some also had changes in the electrical activity of the heart called QT prolongation, which raises the risk for life-threatening, irregular heartbeats. To monitor your risk for heart problems, your provider might check your heart’s ability to pump using an echocardiogram (echo), check your electrolyte levels through blood testing, and check your heart’s electrical activity using an electrocardiogram (ECG).

                        Tell your provider right away if you have symptoms like chest pain, shortness of breath, swelling in the lower legs or feet, racing or irregular heartbeat, lightheadedness, or tiredness. These symptoms might suggest heart problems, and you might need to pause or stop treatment with Votrient (pazopanib) if they occur.

                        risk-warning

                        Serious bleeding

                        Some people who took Votrient (pazopanib) had unusual bleeding, such as nosebleeds and rectal bleeding (blood on toilet paper after you wipe). Let your healthcare provider know immediately if you have any unusual bleeding, especially bleeding that’s hard to stop.

                        Rarely, serious and fatal bleeding has happened. Serious bleeding can happen in any area of the body, including in the lungs, stomach, and brain. Get medical help right away if you feel nauseous, have a sudden or painful headache, notice a change in your vision, have stomach pain, or are coughing or spitting up blood. Your healthcare provider might stop treatment with Votrient (pazopanib) based on how severe the bleed is.

                        risk-warning

                        Blood clots

                        Votrient (pazopanib) can raise your risk for blood clots in your body. Sometimes, blood clots can be life-threatening and lead to stroke or heart attack. Symptoms of a blood clot might be different depending on the location of the clot. They can include trouble walking, blurry vision, breathing problems, chest pain, and swelling in the leg. Get medical attention as soon as possible if you have any of these symptoms. You’ll need to stop stop treatment with Votrient (pazopanib).

                        Votrient (pazopanib) can also cause blood clotting problems called thrombotic microangiopathy (TMA), which includes thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Your provider might monitor for signs of these problems through lab work. You’ll probably need to permanently stop treatment if you develop these conditions.

                        risk-warning

                        Injury in the gut and fistulas

                        Though uncommon, some people who took Votrient (pazopanib) developed tears and fistulas (an abnormal connection from one part of the body to another) in the gut. These problems are serious and can sometimes be life-threatening. Notify your provider if you have symptoms of gut injuries or fistulas, like high fever, shivering, vomiting, severe constipation, pain in the anal area, or severe stomach pain (especially if it doesn’t go away). Your provider might permanently stop your Votrient (pazopanib) treatment.

                        risk-warning

                        Lung problems

                        Though rare, a few people who took Votrient (pazopanib) had serious lung problems, like lung inflammation and interstitial lung disease, which can be fatal. Tell your provider if you have any new or worsening breathing problems, such as shortness of breath, dry cough, and faster breathing. You might need to stop taking Votrient (pazopanib) if you develop lung inflammation or interstitial lung disease.

                        risk-warning

                        Posterior reversible encephalopathy syndrome

                        Posterior reversible encephalopathy syndrome (PRES) is a very rare, but sometimes fatal side effect of Votrient (pazopanib) that affects your nervous system. Let your provider know if you have any symptoms of PRES, like headache, feeling sluggish, confusion, and vision loss. If you develop symptoms, your provider will check for PRES by ordering a brain scan called an MRI (magnetic resonance imaging) for you. Your provider will stop your treatment if it’s confirmed that you have PRES.

                        risk-warning

                        High blood pressure

                        Votrient (pazopanib) can raise your blood pressure, most commonly within the first 4 months of treatment. Don’t start taking this medication until your blood pressure gets under control (with guidance from your provider).

                        Once you’ve started Votrient (pazopanib), regularly check your blood pressure and contact your provider if it rises during treatment. You might need to start blood pressure medications to manage this side effect. Depending on your blood pressure, you also might need to take Votrient (pazopanib) at a lower dosage or even stop the medication. Tell your provider if you feel dizzy or tired or if you have headaches. And get medical help right away if you have signs of extremely high blood pressure, like changes in vision or speech, confusion, shortness of breath, weakness, or numbness.

                        risk-warning

                        Problems with surgery and wound healing

                        Votrient (pazopanib) can make it harder for wounds to heal. Tell your provider if you’re planning to have a surgery or procedure. You shouldn’t take Votrient (pazopanib) a week before and at least 2 weeks after surgery and until your surgical wounds fully heal.

                        risk-warning

                        Thyroid gland problems

                        Votrient (pazopanib) can cause thyroid gland problems like hypothyroidism (low thyroid hormone levels). Symptoms of thyroid gland problems can include weight loss or weight gain, feeling nervous or anxious, depression, eye or neck swelling, feeling hot or cold, sweating, or changes in menstruation. Contact your healthcare provider if you have any of these symptoms. Your provider will check your thyroid hormone levels during treatment and start thyroid replacement therapy if needed.

                        risk-warning

                        Kidney problems

                        It’s possible for Votrient (pazopanib) to cause kidney problems, sometimes causing more proteins than usual to seep into the urine. Your provider will regularly monitor your kidney health through blood tests and urine samples while you’re taking this medication.

                        If you develop kidney problems, your provider might pause treatment until your kidney gets better or stop treatment permanently depending on how severe the problem is. Talk to your provider if you notice any changes in how often you urinate (more or less), any blood in your urine, or any cloudy urine so they can check for kidney issues.

                        risk-warning

                        Tumor lysis syndrome

                        • Risk factors: Fast-growing tumor | High tumor burden | Kidney problems | Dehydration

                          Some people treated with Votrient (pazopanib) have had a serious and sometimes fatal reaction called tumor lysis syndrome (TLS). This reaction happens when many cancer cells quickly die and suddenly break down in your body. In the process, these cells release their inner contents, like uric acid, potassium, and phosphorus, into your blood.

                          High levels of uric acid and electrolytes in your body can cause serious problems, such as kidney damage and abnormal heart rhythms. Your provider will routinely order blood tests to check for signs of TLS. Tell your provider right away if you’re urinating less than usual or if you have dark urine, muscle cramps, or a racing heartbeat.

                          risk-warning

                          Risk of infections

                          Votrient (pazopanib) can raise your risk of getting a serious infection, which can be fatal. To prevent getting sick, stay away from people who are sick and practice good hand hygiene (wash your hands often with soap and water). Tell your provider if you have any signs or symptoms of a new infection, like fever, chills, stuffy nose, cough, ear or sinus pain, pain while urinating, or wounds that won’t heal. If you have an infection, your provider might pause your treatment with Votrient (pazopanib) until you recover from it.

                          risk-warning

                          Harm to an unborn baby

                          Votrient (pazopanib) can cause harm to an unborn baby when it’s taken during pregnancy. If you can have children, your provider might ask you to take a pregnancy test before you start treatment. And if you or your partner can become pregnant, use effective birth control once you start the medication. Continue using birth control for at least 2 weeks after your last dose. Tell your provider right away if you or your partner becomes pregnant during this time.

                          dosage

                          Votrient (pazopanib) dosage forms

                          Typical dosing for Votrient (pazopanib)

                          The typical dose is 800 mg (four 200 mg tablets) by mouth once daily. Your dose might be lower if you have liver problems.

                          During treatment, your dose can change based on how well you tolerate Votrient (pazopanib). It might also change if you’re taking certain medications that interact with Votrient (pazopanib).

                          interactions

                          Interactions between Votrient (pazopanib) and other drugs

                          Votrient (pazopanib) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Votrient (pazopanib). Please note that only the generic name of each medication is listed below.

                          Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                          Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                          drug-cost

                          How much does Votrient (pazopanib) cost?

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                          alternatives

                          What are alternatives to Votrient (pazopanib)?

                          There are a number of medications that your doctor can prescribe in place of Votrient (pazopanib). Compare a few possible alternatives below.
                          Votrient (pazopanib)
                          Used for:
                          • Advanced kidney cancer (renal cell carcinoma)

                          • Advanced soft tissue sarcoma, after previously receiving chemotherapy

                          Used for:
                          $1907.42 Lowest GoodRx priceView Prices
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                          References

                          Best studies we found
                          View All References (20)

                          Arnold, D. M., et al. (2017). Thrombotic microangiopathies: A general approach to diagnosis and management. Canadian Medical Association Journal

                          Gupta, A., et al. (2018). Tumor lysis syndrome. Journal of the American Medical Association Oncology.

                          MedlinePlus. (2022). Bilirubin blood test.

                          MedlinePlus. (2022). Uric acid test.

                          MedlinePlus. (2023). Fistula.

                          National Cancer Institute (n.d.). Hand-foot syndrome

                          National Cancer Institute. (2022). Targeted therapy to treat cancer.

                          National Comprehensive Cancer Network. (2023). Soft tissue sarcoma.

                          National Comprehensive Cancer Network. (2024). Kidney cancer.

                          National Heart, Lung, and Blood Institute. (2022). Thrombotic thrombocytopenic purpura (TTP).

                          National Kidney Foundation. (n.d.). Hemolytic uremic syndrome (HUS).

                          Novartis Pharmaceuticals Corporation. (2024). Votrient- pazopanib hydrochloride tablet, film coated [package insert]. DailyMed.

                          Šeparović, R., et al. (2018). Rapid hair depigmentation in patient treated with pazopanib. British Medical Journal Case Reports.

                          Shibuya, M. (2011). Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: A crucial target for anti- and pro-angiogenic therapies. Genes & Cancer.

                          Sternberg, C. N., et al. (2010). Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial. Journal of Clinical Oncology.

                          Thomson, R. J., et al. (2023). Tyrosine kinase inhibitors. StatPearls.

                          Triplett, J. D., et al. (2022). Posterior reversible encephalopathy syndrome (PRES): Diagnosis and management. Practical Neurology.

                          Wolter, P., et al. (2011). Incidence of thyroid dysfunction in renal cell carcinoma (RCC) patients treated with pazopanib in prospective clinical trials. Journal of Clinical Oncology.

                          Yun, H. J., et al. (2015). Gray hair associated with the multitargeted receptor tyrosine kinase inhibitor pazopanib. Annals of Dermatology.

                          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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