The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
When used with other anticancer medications:
- Diarrhea (81%)
- Rash, redness, pain, or blisters on the palms of your hands or soles of your feet (hand-foot syndrome, 63%)
- Nausea (58%)
- Liver damage (42%)
- Vomiting (36%)
- Pain, sores, blisters, or inflammation in the mouth (32%)
- Lower appetite (25%)
Less Common Side Effects
- Headache
- Tiredness
- Stomach pain
- Joint pain
- Nerve damage
- Rash
- Weight loss
- Anemia
- Nose bleed
Tukysa serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe diarrhea
- Liver problems: yellowing of skin or whites of your eyes, dark-colored urine, right upper stomach pain or discomfort, itchy skin
Source: DailyMed
The following Tukysa side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

