Skip to main content
Trimipramine Coupon - Trimipramine 25mg capsule

trimipramine

Generic Surmontil
Used for Depression

Trimipramine is taken by mouth and used to treat depression. It's not a first-choice medication because it can cause many side effects, such as dizziness, dry mouth, anxiety, or heart problems.

Reviewed by:
reviewerAllison Gourley, PharmD
reviewerMichelle Nguyen, PharmD
Last reviewed on January 13, 2022
basics-icon

What is Trimipramine?

What is Trimipramine used for?

  • Depression

How Trimipramine works

Trimipramine is a tricyclic antidepressant. The exact way that it works to treat depression is unknown. But it's thought to make your brain more sensitive to serotonin, a natural chemical in your brain. This is likely to improve mood.

Drug facts

Common BrandsSurmontil(brand no longer available)
Drug ClassTricyclic antidepressant
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
side-effects-icon

Side effects of Trimipramine

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Drowsiness
  • Blood pressure changes
  • Feeling of pins and needles in your arms and legs
  • Dry mouth
  • Blurred vision
  • Nausea and vomiting

Less Common Side Effects

  • Skin rash
  • Loss of appetite
  • Change in sex drive
  • Headache
  • Stomach cramps

Trimipramine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts and behaviors
  • Serotonin syndrome: high fever, sudden changes in thought, mood, and movement, or high blood pressure
  • Heart attack: new or worsening chest pain, fast or irregular heartbeat, dizziness, tiredness, clammy skin, nausea, vomiting
  • Stroke: tiredness, weakness, difficulty speaking, difficulty maintaining balance, headache, feeling confused, not able to move one side of your body

Source: DailyMed

The following Trimipramine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain

agitation

black, tarry stools

bleeding or bruising

blood in the urine or stools

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort

clay-colored stools

cold sweats

confusion about identity, place, and time

continuing ringing, buzzing, or other unexplained noise in the ears

convulsions

cool, pale skin

cough or hoarseness

dark urine

decrease in the frequency of urination

decreased urine output or volume

depression

difficulty in passing urine (dribbling)

difficulty with speaking

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

double vision

drooling

dry mouth

false beliefs that cannot be changed by facts

fast, pounding, or irregular heartbeat or pulse

feeling of warmth

feeling that others are watching you or controlling your behavior

feeling that others can hear your thoughts

feeling, seeing, or hearing things that are not there

fever with or without chills

flushed, dry skin

fruit-like breath odor

general feeling of tiredness or weakness

headache

hearing loss

hostility

hyperventilation

inability to move the arms, legs, or facial muscles

inability to speak

increased hunger

increased need to urinate

increased thirst

increased urination

irritability

itching or rash

lack of coordination

lethargy

loss of appetite

loss of balance control

lower back or side pain

mood or mental changes

muscle spasm or jerking of all extremities

muscle trembling or stiffness

muscle twitching

nausea

nightmares

pain or discomfort in the arms, jaw, back, or neck

painful or difficult urination

passing urine more often

pinpoint red or purple spots on the skin

pounding in the ears

rapid weight gain

redness of the face, neck, arms, and occasionally, upper chest

restlessness

shakiness and unsteady walk

shuffling walk

slow speech

slurred speech

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stiffness of the limbs

sudden loss of consciousness

sweating

swelling of the face, ankles, legs, or hands

swollen glands

talking, feeling, and acting with excitement

trouble in holding or releasing urine

trouble sleeping

twisting movements of the body

uncontrolled movements, especially of the face, neck, and back

unpleasant breath odor

unsteadiness, awkwardness, trembling, or other problems with muscle control or coordination

unusual behavior

unusual tiredness or weakness

vomiting of blood

weakness in the arms, hands, legs, or feet

weight gain or loss

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Abdominal or stomach cramps

bigger, dilated, or enlarged pupils (black part of the eye)

black tongue

bloating

decreased interest in sexual intercourse

diarrhea

difficulty having a bowel movement (stool)

disturbance of accommodation

enlargement of the breast

hair loss or thinning of the hair

heartburn

hives or welts

inability to have or keep an erection

increase in sexual ability, desire, drive, or performance

increased sensitivity of the eyes to light

increased sensitivity of the skin to sunlight

loss in sexual ability, desire, drive, or performance

pain or discomfort in the chest, upper stomach, or throat

peculiar taste

redness or other discoloration of the skin

severe sunburn

small red or purple spots on the skin

swelling of the breasts or breast soreness in both women and men

swelling of the testicles

swelling or inflammation of the mouth

swollen, painful, or tender lymph glands in the neck

unexpected milk flow from the breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See more Trimipramine side effects
prices-container

Get your GoodRx coupon

Avg retail price
$214.47(Save 82.77%)
GoodRx discount
$36.95
See prices
pros-and-cons-icon

Pros and cons of Trimipramine

Pros

  • Available as a lower-cost generic
  • Available in 3 different strengths, convenient if you need to adjust your dose
  • Can be taken once a day, usually before you go to bed

Cons

  • Might not notice changes in your mood until you've taken trimipramine for several weeks
  • Stopping trimipramine suddenly can cause withdrawal symptoms, such as nausea, headache, and discomfort
  • Can cause more side effects than other medications used to treat depression
  • Not recommended for use for people with certain medical conditions, such as heart problems, thyroid problems, or seizures
pharmacist-tips-icon

Pharmacist tips for Trimipramine

pharmacist
  • Trimipramine can cause a lot of side effects. To help your body get used to the medication, your provider will start you at a low dose. They'll adjust your dose if you're not getting enough benefit from the medication, as long as you don't have side effects. Let your provider or pharmacist know before you start any new medications, including over-the-counter medications or supplements, so they can make sure that it's safe.
  • Make sure your provider has a full list of the medications you take or have recently taken (within the last 2 weeks). Trimipramine can have dangerous interactions with certain medications.
  • Since trimipramine can make you sleepy, don't drive or do anything that requires concentration or focus until you know how your body reacts to it.
  • Even if you start to feel better and less depressed, you'll need to keep taking trimipramine as your provider prescribed.
  • Don't stop taking trimipramine without talking to your provider first. If you want to stop, ask your provider how to do so safely. Stopping this medication suddenly can cause withdrawal symptoms, such as headache, nausea, or discomfort.
  • Be very careful getting up if you've been sitting or lying down for a while since trimipramine can make you feel dizzy or cause you to fall.
warnings-icon

Risks and warnings for Trimipramine

Trimipramine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Suicidal thoughts or behavior

  • Risk factors: People 24 years or younger | History of depression or other mood problems | Taking antidepressants | Starting trimipramine for the first time | Change in dose of trimipramine

Black Box WarningTrimipramine can raise the risk of suicidal thoughts or behavior. Watch for new or worsening depression, suicidal thoughts or behavior, especially during the first few months of treatment or when the dose changes. Let your healthcare provider know right away if you notice any unusual changes in mood or behavior while taking this medication.

Possible bipolar disorder

Sometimes depression can be the first sign of bipolar disorder. Unfortunately, trimipramine doesn't treat bipolar and can cause a manic phase. Your provider will screen you for bipolar disorder before starting trimipramine. Let them know your full medical history and if anyone in your family has a history of bipolar disorder.

Serotonin syndrome

  • Risk factors: Taking trimipramine with tricyclic antidepressants, fentanyl, tramadol, buspirone, ADHD medications, triptan medications, or SSRI antidepressants

In some rare cases, taking trimipramine can lead to serotonin syndrome. Symptoms can include high fever, sudden changes in thought, mood, and movement, or high blood pressure. This is more likely to happen if you take certain medications for depression, migraines, or pain control. Tell your provider or pharmacist about all the medications you take before starting trimipramine.

Heart problems

  • Risk factors: History of heart disease

If you have a history of heart disease, talk to your provider or pharmacist before taking trimipramine. People have had faster heartbeats or irregular heartbeats while taking trimipramine. People have also had heart attacks and strokes while on trimipramine.

Drowsiness or sleepiness

During the first few days of taking trimipramine, you might feel sleepy or drowsy. Be very careful driving or doing anything that requires concentration until you know how trimipramine affects you. This usually goes away after a few days to a week. Talk to your provider if you find the drowsiness isn't getting better, they may suggest taking your dose once a day at bedtime or they may switch you to a different medication.

Withdrawal symptoms

If you've been taking trimipramine for a while and want to stop taking it, talk to your provider first. While it's not addictive, stopping trimipramine suddenly can cause nausea, headache, and uneasiness for a few days until your body readjusts. Your provider will work with you to lessen the discomfort.

dosage-icon

Trimipramine dosage

The average cost for 30 capsules of 25mg of Trimipramine is $36.95 with a free GoodRx coupon. This is 82.77% off the average retail price of $214.47.
capsuleCapsule
DosageQuantityPrice as low asPrice per unit
25mg30 capsules$36.95$1.23
50mg60 capsules$106.70$1.78
100mg90 capsules$218.61$2.43
See more Trimipramine dosage
interactions-icon

Interactions between Trimipramine and other drugs

Trimipramine may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Trimipramine. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Arbutamine
  • Atomoxetine
  • Cannabis
  • Dicumarol
  • Phenprocoumon
  • S-Adenosylmethionine
See more Trimipramine interactions
cost-icon

How much does Trimipramine cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Trimipramine (generic)
GoodRx lowest price

$36.95

(save 94.77%)
View prices and coupons
contraindications-icon

Trimipramine contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Trimipramine will not be safe for you to take.

  • Recovering from a recent heart attack
  • Taking trimipramine within 14 days of a monoamine oxidase inhibitor (MAOI)
alternatives-icon

What are alternatives to Trimipramine?

There are a number of medications that your doctor can prescribe in place of Trimipramine. Compare a few possible alternatives below.
Trimipramine
Used for:
  • Depression
$36.95Lowest GoodRx priceView prices
Used for:
$4.00Lowest GoodRx priceView prices
Used for:
  • Depression
  • Bedwetting in children (imipramine hydrochloride only)
$10.66Lowest GoodRx priceView prices
latest-news-icon

News about Trimipramine

images-icon

Trimipramine images

Blue And Yellow A-293 A-293 - Trimipramine Maleate 25mg Capsule
This medicine is Blue And Yellow Capsule Imprinted With "A-293 A-293".Blue And Yellow A-293 A-293 - Trimipramine Maleate 25mg Capsule
Blue And Yellow A-293 A-293 - Trimipramine Maleate 25mg Capsule
This medicine is Blue And Yellow Capsule Imprinted With "A-293 A-293".Blue And Yellow A-293 A-293 - Trimipramine Maleate 25mg Capsule