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Sulfamethoxazole / Trimethoprim Coupon - Sulfamethoxazole / Trimethoprim 800mg/160mg tablet

sulfamethoxazole / trimethoprim

Generic Sulfatrim
Used for Ear Infection, Urinary Tract Infection, Lower Respiratory Infection, Pneumonia, Gastrointestinal Infection, Diarrhea
Used for Ear Infection, Urinary Tract Infection, Lower Respiratory Infection, Pneumonia, Gastrointestinal Infection, Diarrhea

Sulfatrim Pediatric (sulfamethoxazole / trimethoprim) is an antifolate and sulfa antibiotic. It treats several types of infections, including urinary tract infections (UTIs), ear infections, and lung infections. This antibiotic is a cherry-flavored liquid suspension that's available as a brand-name product and a lower-cost generic. Even though Sulfatrim is branded for use in children, it's also a good choice for adults who have trouble swallowing the tablet version of the antibiotic. Side effects include stomach upset, nausea, and rash.

Last reviewed on May 15, 2024
basics-icon

What is Sulfatrim (sulfamethoxazole / trimethoprim)?

What is Sulfatrim (sulfamethoxazole / trimethoprim) used for?

How Sulfatrim (sulfamethoxazole / trimethoprim) works

Sulfatrim (sulfamethoxazole / trimethoprim) is a combination of two antibiotics, sulfamethoxazole (a sulfonamide) and trimethoprim (antifolate). They work together to stop bacteria from being able to make folic acid, which is a nutrient that bacteria need to grow and survive. By stopping bacteria from making folic acid, Sulfatrim (sulfamethoxazole / trimethoprim) kills bacteria.

Are you looking for information on trimethoprim or sulfamethoxazole/trimethoprim (Bactrim, Septra) instead?
When does Sulfatrim (sulfamethoxazole / trimethoprim) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsSulfatrim
Drug ClassSulfonamide antibiotic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Sulfatrim (sulfamethoxazole / trimethoprim)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Muscle pain
  • Joint pain
  • Fatigue
  • Weakness
  • Trouble falling asleep
  • Changes to blood sugar levels

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction or skin reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing
  • Infectious diarrhea (C. difficile-related diarrhea): rapid heart rate, fever, nausea, foul-smelling diarrhea, frequent bowel movements (even up to 15 times per day)
  • High potassium levels: nausea, muscle cramps or weakness
  • Low sodium levels: nausea, fatigue, headache, confusion, hallucinations (seeing things that aren't real), seizure, unconsciousness
  • Kidney problems: urinating less often than usual; swelling in your feet, ankles, or hands; unexplained weight gain
When do Sulfatrim (sulfamethoxazole / trimethoprim) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Nausea or vomiting
Stomach upset
Skin sensitivity to sun (risk for sunburn)
Skin rash
Seek immediate medical care if you experience this side effect.

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Black, tarry stools

blistering, peeling, or loosening of the skin

changes in skin color

chest pain or tightness

chills

cough or hoarseness

dark urine

diarrhea

dizziness

fever

general feeling of tiredness or weakness

headache

itching, skin rash

joint or muscle pain

light-colored stools

loss of appetite

lower back or side pain

nausea

pain, tenderness, or swelling of the foot or leg

painful or difficult urination

pale skin

red skin lesions, often with a purple center

red, irritated eyes

sore throat

sores, ulcers, or white spots in the mouth or on the lips

stomach pain

swollen or painful glands

trouble breathing

unpleasant breath odor

unusual bleeding or bruising

vomiting of blood

yellow eyes or skin

Incidence not known

Back, leg, or stomach pains

bleeding gums

blindness or vision changes

bloating

blood in the urine or stools

bluish-colored lips, fingernails, or palms

burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings

burning of the face or mouth

cloudy urine

confusion

constipation

continuing ringing or buzzing or other unexplained noise in the ears

cracks in the skin

decreased frequency or amount of urine

difficulty with swallowing

fainting spells

general body swelling

general feeling of discomfort or illness

hair loss

hearing loss

hives

increased thirst

indigestion

irregular heartbeat

large, flat, blue, or purplish patches in the skin

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of heat from the body

muscle or joint pain

nosebleeds

not able to pass urine

numbness or tingling in the hands, feet, or lips

pain or burning while urinating

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

raised red swellings on the skin, the buttocks, legs, or ankles

redness of the white part of the eyes

redness, swelling, or soreness of the tongue

seizures

soreness of the muscles

stiff neck or back

stomach tenderness

swelling of the face, hands, legs, and feet

unsteadiness, trembling, or other problems with muscle control or coordination

weakness in the hands or feet

weakness or heaviness of the legs

weight gain or loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Passing of gas

Incidence not known

Discouragement

feeling of constant movement of self or surroundings

feeling sad or empty

increased sensitivity of the skin to sunlight

lack of feeling or emotion

loss of interest or pleasure

nervousness

redness or other discoloration of the skin

seeing, hearing, or feeling things that are not there

sensation of spinning

severe sunburn

trouble concentrating

trouble sleeping

uncaring

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Sulfatrim (sulfamethoxazole / trimethoprim)

thumbs-up

Pros

Works well to treat many types of bacterial infections

Available as a lower-cost generic

Cherry-flavored for better taste

thumbs-down

Cons

Not a good choice if you have a sulfa allergy

Not recommended if you're pregnant or if you have liver or kidney problems

Some suspensions contain a small amount of alcohol

pharmacist-tips

Pharmacist tips for Sulfatrim (sulfamethoxazole / trimethoprim)

pharmacist
  • Shake the bottle well before you measure out your dose. Make sure to only use a medication dose cup or oral syringe from the pharmacy to measure the dose. Don't use household spoons; they might not be accurate and using them can cause you to take the wrong dose of Sulfatrim (sulfamethoxazole / trimethoprim).

    • Take Sulfatrim (sulfamethoxazole / trimethoprim) with or without food. But nausea and upset stomach are common, so taking it with food might help prevent or ease these side effects.

      • Take Sulfatrim (sulfamethoxazole / trimethoprim) exactly as prescribed. Be sure to finish your antibiotics, even if you're feeling better. Stopping the antibiotic earlier than prescribed can raise the risk that your infection can come back and be harder to treat.

        • Drink plenty of fluids while you're taking Sulfatrim (sulfamethoxazole / trimethoprim). Staying hydrated can help lessen the chance of possible kidney problems with this antibiotic.

          • Get medical help right away if you have watery or bloody diarrhea, stomach cramps, or fever at any time during treatment or after stopping Sulfatrim (sulfamethoxazole / trimethoprim). These could be signs of serious diarrhea from a Clostridiodes difficile (C. diff) infection. This infectious diarrhea needs to be treated as soon as possible.

            • Ask a healthcare professional (HCP) whether you can take a probiotic with Sulfatrim (sulfamethoxazole / trimethoprim). Probiotics might help lessen the risk of getting a C. diff infection that can happen with antibiotic treatment. Separate the probiotic from Sulfatrim (sulfamethoxazole / trimethoprim) by at least 2 hours to prevent the antibiotic from killing the "good" bacteria in the probiotic.

              • It's possible for your blood sugar levels to drop while you're taking Sulfatrim (sulfamethoxazole / trimethoprim). The risk might be higher if you have liver or kidney problems or poor nutrition. If you have diabetes, ask your HCP whether you need to check your blood sugar more often while you're taking this antibiotic.

                • In general, it's okay to breastfeed while you're taking Sulfatrim (sulfamethoxazole / trimethoprim) if your baby is older than 2 months and was born full-term. But it isn't recommended to nurse while you're treated with this antibiotic if your baby was born premature, is sick, or has jaundice. To be safe, speak with your baby's primary care provider about breastfeeding while you're taking this antibiotic.

                  faqs

                  Frequently asked questions about Sulfatrim (sulfamethoxazole / trimethoprim)

                  How long does it take for Sulfatrim (sulfamethoxazole / trimethoprim) to work?
                  Sulfatrim (sulfamethoxazole / trimethoprim) generally starts to work quickly, though it depends on what infection you have and how serious it is. For example, you should start feeling better in a few days after you start taking the antibiotic for a urinary tract infection (UTI). But for more serious infections, like pneumonia, it can take a couple weeks to feel better. No matter what infection you have and when you start feeling better, it's important to take Sulfatrim (sulfamethoxazole / trimethoprim) exactly as prescribed and finish your treatment course. Stopping the antibiotic earlier than prescribed can make your infection come back and be harder to treat.
                  Does Sulfatrim (sulfamethoxazole / trimethoprim) need to be refrigerated?
                  No, Sulfatrim (sulfamethoxazole / trimethoprim) should be stored only at room temperature in the original bottle to be protected from light.
                  Is Sulfatrim the same as Bactrim?
                  No, but they're very similar. Sulfatrim Pediatric (better known as just Sulfatrim) and Bactrim are brand-name medications that contain the same active ingredients, sulfamethoxazole and trimethoprim. The only difference between both brand names is that Sulfatrim is a liquid suspension and Bactrim is a tablet. Sulfatrim is a good choice for people who don't like to take or who are having trouble swallowing Bactrim tablets.
                  Will Sulfatrim (sulfamethoxazole / trimethoprim) treat strep throat?
                  No, Sulfatrim (sulfamethoxazole / trimethoprim) isn't one of the antibiotics recommended for strep throat. Typically, antibiotics like amoxicillin or cephalexin (Keflex) are prescribed for strep throat.
                  Can you drink alcohol while you're taking Sulfatrim (sulfamethoxazole / trimethoprim)?
                  You should generally avoid drinking alcohol while you're taking antibiotics like Sulfatrim (sulfamethoxazole / trimethoprim). Alcohol can weaken your immune system and make it harder for you to recover from an infection. It can also worsen certain side effects of Sulfatrim (sulfamethoxazole / trimethoprim), such as diarrhea, nausea, and vomiting. Talk to a healthcare professional about your drinking habits and ways to avoid alcohol before you start taking this antibiotic.
                  Does Sulfatrim (sulfamethoxazole / trimethoprim) contain sulfa?
                  Yes. One of the active ingredients, sulfamethoxazole, is a sulfa drug. So Sulfatrim (sulfamethoxazole / trimethoprim) might not be a good choice for you if you have a sulfa allergy. Tell your prescriber what your reaction to sulfa was like in the past; this will help your prescriber decide whether to use Sulfatrim (sulfamethoxazole / trimethoprim) to treat your infection. You still might get prescribed Sulfatrim (sulfamethoxazole / trimethoprim) if you typically get a mild rash or itchy skin from a sulfa medication. Just make sure to watch closely for allergic reactions. But your prescriber will probably choose a different antibiotic to treat your infection if you had a severe reaction, like facial swelling, trouble breathing, or anaphylaxis.
                  Does Sulfatrim (sulfamethoxazole / trimethoprim) have penicillin?
                  No, Sulfatrim (sulfamethoxazole / trimethoprim) doesn't have a penicillin or any antibiotic that's closely related to a penicillin in it. This means that it's safe for you to take Sulfatrim (sulfamethoxazole / trimethoprim) if you have a penicillin allergy.
                  Does Sulfatrim (sulfamethoxazole / trimethoprim) expire?
                  Yes, Sulfatrim (sulfamethoxazole / trimethoprim) can expire. There should be an expiration date that's written on the medication bottle that you picked up from the pharmacy. Don't use Sulfatrim (sulfamethoxazole / trimethoprim) past the written expiration date. Expired Sulfatrim (sulfamethoxazole / trimethoprim) might not work well to help treat your infection and it might make you sicker.
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                  What are the risks and warnings for Sulfatrim (sulfamethoxazole / trimethoprim)?

                  Sulfatrim (sulfamethoxazole / trimethoprim) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Not for use during pregnancy

                  Sulfatrim (sulfamethoxazole / trimethoprim) isn't recommended during pregnancy because there's a risk that the antibiotic can cause severe developmental harm to an unborn baby. Let your prescriber know if you're pregnant or thinking of becoming pregnant before starting this antibiotic. Also contact your prescriber right away if you become pregnant while you're taking Sulfatrim (sulfamethoxazole / trimethoprim). Your prescriber can discuss safer treatment options for you.

                  risk-warning

                  Severe allergic reactions and skin reactions

                  • Risk factors: Allergy to sulfa

                    Severe allergic reactions to Sulfatrim (sulfamethoxazole / trimethoprim) are possible, including life-threatening reactions, like facial swelling and anaphylaxis. Although rare, this antibiotic can also cause serious skin reactions, such as Stevens-Johnson syndrome (SJS) and drug reaction with eosinophilia and systemic symptoms (DRESS syndrome).

                    Let your prescriber know if you have an allergy to antibiotics or medications, especially any sulfa drugs, to make sure this antibiotic is safe for you. Stop taking Sulfatrim (sulfamethoxazole / trimethoprim) and get medical help right away if you have hives, rash, blisters, skin reddening, skin peeling, swelling of the lips or tongue, or trouble breathing.

                    risk-warning

                    Low platelet counts and risk for bleeding

                    • Risk factors: Taking Sulfatrim (sulfamethoxazole / trimethoprim) together with medications that raise your bleeding risk

                      Sulfatrim (sulfamethoxazole / trimethoprim) can lower your platelet count (thrombocytopenia). Having a low platelet count can put you at risk for serious bleeding. Your risk is higher if you're taking this antibiotic with other medications that also raise your bleeding risk, such as aspirin or warfarin (Coumadin). Typically, platelet counts go back to usual within a week after stopping the antibiotic.

                      Seek medical help right away if you have any unusual bleeding; bleeding that lasts for a long time; trouble stopping bleeds; easy bruising; or blood in your vomit, urine, or stool. Speak to a healthcare professional (HCP) if you have concerns.

                      risk-warning

                      Diarrhea from Clostridioides difficile infection

                      Sulfatrim (sulfamethoxazole / trimethoprim) can raise your risk of getting infected with a bacteria called Clostridioides difficile (C. diff). Antibiotics change the amount of normal bacteria in your stomach and intestines. This can cause C. diff to overgrow in your gut and lead to an infection. C. diff infection can cause severe diarrhea.

                      It's important to recognize the difference between diarrhea as a side effect of Sulfatrim (sulfamethoxazole / trimethoprim) and C. diff-related diarrhea. This type of infectious diarrhea can cause rapid heart rate, fever, nausea, foul-smelling diarrhea, and frequent bowel movements (even up to 15 times per day). It's a medical emergency, so get help as soon as possible if you have any symptoms of a C. diff infection. You'll need to get tested for C. diff infection and get treatment.

                      risk-warning

                      Low sodium levels and high potassium levels

                      • Risk factors: Taking high doses of Sulfatrim (sulfamethoxazole / trimethoprim) | Kidney problems

                        Sulfatrim (sulfamethoxazole / trimethoprim), especially at high dosages, can raise your potassium levels and lower your sodium levels. Contact an HCP right away if you experience weakness, tingling or numbness, headache, confusion, trouble concentrating, or memory problems.

                        risk-warning

                        Blood cell-related problems

                        • Risk factors: Genetic condition called glucose-6 phosphate dehydrogenase (G6PD) deficiency | Older adult | Regularly drink alcohol | Kidney problems | Liver problems | Poor nutrition

                          Taking Sulfatrim (sulfamethoxazole / trimethoprim) can lead to some blood-cell related problems in certain people. For example, people who have certain genetic conditions are at risk of having their red blood cells damaged and broken down when they take this antibiotic.

                          Taking Sulfatrim (sulfamethoxazole / trimethoprim) can also sometimes make it more difficult for your body to absorb an important vitamin called folic acid. This can sometimes lead to low folic acid levels, which can affect how well your body can make blood cells. Low folic acid levels might be more likely if you're an older adult, if you regularly drink large amounts of alcohol, or if you have kidney or liver problems.

                          risk-warning

                          Problems with processing phenylalanine - for people with phenylketonuria (PKU) only

                          People with a rare genetic condition called phenylketonuria should follow a low-protein diet while they're taking Sulfatrim (sulfamethoxazole / trimethoprim). This genetic condition happens when the body has trouble processing a nutrient called phenylalanine. And Sulfatrim (sulfamethoxazole / trimethoprim) can make it even harder for the body to break down this nutrient. Following a proper diet seems to help lower your chance of having any noticeable PKU problems.

                          dosage

                          Sulfatrim (sulfamethoxazole / trimethoprim) dosage forms

                          ml of oral suspension
                          Ml of oral suspension
                          DosageQuantityPrice as low asPrice per unit
                          200mg/40mg/5ml200 ml$25.03$0.13

                          Typical dosing for Sulfatrim (sulfamethoxazole / trimethoprim)

                          Each 5 mL (teaspoonful) of Sulfatrim contains 200 mg of sulfamethoxazole and 40 mg of trimethoprim.

                          • Urinary tract infections (UTI) or shigellosis

                            • Adults: The typical dose is 20 mL (four teaspoonfuls) by mouth every 12 hours. This antibiotic is taken for 10 to 14 days for UTI and 5 days for shigellosis.

                            • Children age 2 months and older: The prescriber will calculate the dose based on your child's body weight. The typical dose is 20 mg/kg of sulfamethoxazole and 4 mg/kg of trimethoprim by mouth every 12 hours. It's taken for 10 days for UTI and 5 days for shigellosis.

                          • Ear infections

                            • Children age 2 months and older only: The prescriber will calculate the dose based on your child's body weight. The typical dose is 20 mg/kg of sulfamethoxazole and 4 mg/kg of trimethoprim by mouth every 12 hours for 10 days.

                          • Infections related to bronchitis

                            • Adults only: The typical dose is 20 mL (four teaspoonfuls) by mouth every 12 hours for 14 days.

                          • Pneumocystis pneumonia

                            • Prevention

                              • Adults: The typical dose is 20 mL (four teaspoonfuls) by mouth once per day.

                              • Children age 2 months and older: The prescriber will calculate the dose based on your child's body weight and height. In general, the typical dose ranges from 2.5 mL to 10 mL by mouth every 12 hours.

                            • Treatment

                              • Adults and children age 2 months and older: The prescriber will calculate your dose based on your body weight. The typical dose is 75 mg/kg to 100 mg/kg of sulfamethoxazole and 15 mg/kg to 20 of mg/kg trimethoprim by mouth per day. The daily dose is divided into equal doses that are taken every 6 hours. Treatment typically lasts for 2 to 3 weeks.

                          • Travelers' diarrhea

                            • Adults only: The typical dose is 20 mL (four teaspoonfuls) by mouth every 12 hours for 5 days.

                          Your dose might differ if you have kidney problems.

                          interactions

                          Interactions between Sulfatrim (sulfamethoxazole / trimethoprim) and other drugs

                          Sulfatrim (sulfamethoxazole / trimethoprim) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Sulfatrim (sulfamethoxazole / trimethoprim). Please note that only the generic name of each medication is listed below.

                          More on Sulfatrim (sulfamethoxazole / trimethoprim) interactions

                          Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                          Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                          Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                          contraindications-icon

                          Sulfatrim (sulfamethoxazole / trimethoprim) contraindications

                          Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Sulfatrim (sulfamethoxazole / trimethoprim) will not be safe for you to take.
                          alternatives

                          What are alternatives to Sulfatrim (sulfamethoxazole / trimethoprim)?

                          There are a number of medications that your doctor can prescribe in place of Sulfatrim (sulfamethoxazole / trimethoprim). Compare a few possible alternatives below.
                          latest news

                          What is the latest news about Sulfatrim (sulfamethoxazole / trimethoprim)?

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                          Sulfatrim (sulfamethoxazole / trimethoprim) images

                          Sulfatrim Coupon - Sulfatrim 200mg / 40mg / 5ml oral suspension
                          ml 200mg/40mg/5ml of Sulfatrim oral suspensionSulfatrim Coupon - Sulfatrim 200mg / 40mg / 5ml oral suspension
                          Sulfamethoxazole / Trimethoprim Coupon - Sulfamethoxazole / Trimethoprim 200mg / 40mg / 5ml oral suspension
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                          References

                          Best studies we found

                          Centers for Disease Control and Prevention. (2024). Pneumocystis pneumonia basics.

                          Drugs and Lactation Database (LactMed®). (2021). Trimethoprim-sulfamethoxazole. National Institute of Child Health and Human Development.

                          Hariz, A., et al. (2023). Megaloblastic anemia.

                          View All References (7)

                          Kemnic, T. R., et al. (2022). Trimethoprim sulfamethoxazole. StatPearls.

                          MedlinePlus. (2016). Phenylketonuria.

                          MedlinePlus. (2023). Folic-acid - test.

                          MedlinePlus. (2023). Glucose-6-phosphate dehydrogenase deficiency.

                          National Heart, Lung, and Blood Institute. (2022). Thrombocytopenia.

                          PAI Holdings, LLC dba PAI Pharma. (2024). Sulfatrim- sulfamethoxazole and trimethoprim suspension [package insert]. DailyMed.

                          Shahzad, S., et al. (2020). Folic acid-sulfonamide conjugates as antibacterial agents: Design, synthesis and molecular docking studies. RSC Advances.

                          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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