Propantheline is an oral medication that's usually taken with other medications to treat stomach ulcers. It's no longer available in the United States because it was discontinued.
Add-on therapy for the treatment of stomach ulcers
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Prevention and treatment of heartburn (gastroesophageal reflux disease or GERD)
Gastric ulcer (open sore in the stomach)
Duodenal ulcer (open sore in the first part of the small intestine)
Heartburn (GERD)
Erosive esophagitis due to GERD (inflammation of the esophagus)
Other conditions that cause too much stomach acid secretion (i.e., Zollinger-Ellison syndrome)
Heartburn — OTC only
Lower the risk of duodenal ulcer caused by Helicobacter pylori (H. pylori) infection
Other medical conditions that cause too much stomach acid (e.g., Zollinger-Ellison syndrome)
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Department of Health and Human Services and U.S. Food and Drug Administration. (2010). Determination that PRO-BANTHINE (Propantheline Bromide) tablets and 14 other drug products were not withdrawn from sale for reasons of safety or effectiveness. Federal Register.
Kamada, T., et al. (2021). Evidence-based clinical practice guidelines for peptic ulcer disease 2020. Journal of Gastroenterology.
Purves, D., et al. (2001). Acetylcholine. Neuroscience, 2nd edition.
West-Ward Pharmaceuticals Corp. (2016). PROPANTHELINE BROMIDE- propantheline bromide tablet, film coated [package insert]. DailyMed.
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