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propantheline

Generic Pro-Banthine
Used for Peptic Ulcer
Used for Peptic Ulcer

Propantheline is an oral medication that's usually taken with other medications to treat stomach ulcers. It's no longer available in the United States because it was discontinued.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Daisy Chau, PharmD
Last reviewed on January 3, 2023
BasicsFAQsInteractionsAlternativesReferencesPricesMedicare
basics-icon

What is Propantheline?

What is Propantheline used for?

  • Add-on therapy for the treatment of stomach ulcers

How Propantheline works

Drug Facts

Common BrandsPro-Banthine (brand no longer available)
Drug ClassAnticholinergic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
faqs

Frequently asked questions about Propantheline

What is propantheline?
Propantheline is an anticholinergic that's used to treat stomach ulcers. It works by blocking a chemical called acetylcholine in your gut. This helps to relax your gut muscles and lower the amount of acid your stomach makes to allow your stomach ulcers to heal.
Is propantheline still available?
No, propantheline has been discontinued and is no longer available in the United States. It's not completely clear why propantheline has been discontinued, but it wasn't due to safety or efficacy reasons from the medication.
What medications are used in place of propantheline?
Proton pump inhibitors (PPIs) like omeprazole (Prilosec) are first-choice options for the treatment of stomach ulcers. And histamine-2 antagonists like famotidine (Pepcid AC) are also considered good options for treating stomach ulcers. Talk to your provider to see which medication is best for your condition.
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interactions

Interactions between Propantheline and other drugs

Propantheline may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Propantheline. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

alternatives

What are alternatives to Propantheline?

There are a number of medications that your doctor can prescribe in place of Propantheline. Compare a few possible alternatives below.
Propantheline
Used for:

  • Add-on therapy for the treatment of stomach ulcers

View Prices
Famotidine (Pepcid AC)
Used for:

  • Prevention and treatment of heartburn (gastroesophageal reflux disease or GERD)

$6.60 Lowest GoodRx priceView Prices
Omeprazole (Prilosec)
Used for:

  • Gastroesophageal reflux disease (GERD)

  • Inflamed esophagus due to GERD

$5.88 Lowest GoodRx priceView Prices

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References

Best studies we found

Department of Health and Human Services and U.S. Food and Drug Administration. (2010). Determination that PRO-BANTHINE (Propantheline Bromide) tablets and 14 other drug products were not withdrawn from sale for reasons of safety or effectiveness. Federal Register.

Kamada, T., et al. (2021). Evidence-based clinical practice guidelines for peptic ulcer disease 2020. Journal of Gastroenterology.

Purves, D., et al. (2001). Acetylcholine. Neuroscience, 2nd edition.

View All References (1)

West-Ward Pharmaceuticals Corp. (2016). PROPANTHELINE BROMIDE- propantheline bromide tablet, film coated [package insert]. DailyMed.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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