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Orserdu Coupon - Orserdu 345mg tablet

Orserdu

elacestrant
Used for Breast Cancer
Used for Breast Cancer

Orserdu (elacestrant) is a selective estrogen receptor degrader (SERD), also known as an antiestrogen. It's used to treat advanced or metastatic ER-positive, HER2-negative breast cancer. Orserdu (elacestrant) isn't a first-choice option for this type of cancer, but typically only prescribed when other hormone therapy stopped working. Orserdu (elacestrant) is available as a tablet that’s taken by mouth once a day. This medication can cause side effects such as nausea, and muscle and joint pain.

Reviewed by:
reviewer
Julia Lee, PharmD, BCOP
reviewer
Connie Zheng, PharmD
Last reviewed on September 21, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageAlternativesImagesReferencesPricesMedicare
basics-icon

What is Orserdu (elacestrant)?

What is Orserdu (elacestrant) used for?

How Orserdu (elacestrant) works

Many breast cancers depend on hormones, like estrogen and progesterone, to grow. These specific types of breast cancer have the estrogen receptor (ER) or progesterone receptor (PR) on their cells. They are called hormone-receptor positive (HR+) breast cancer.

Orserdu (elacestrant) is a selective estrogen receptor degraders (SERDs), which is a type of hormone therapy. It binds and destroys estrogen receptors on breast cancer cells. Without estrogen, the breast cancer cells can’t grow or spread as easily.

Drug Facts

Common BrandsOrserdu
Drug ClassSelective estrogen receptor degrader (SERD)
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Orserdu (elacestrant)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Muscle, bone or joint pain (41%)
  • Nausea (35%)
  • Higher blood cholesterol and triglyceride levels (up to 30%)
  • Signs of stress to the liver on blood tests (up to 29%)
  • Feeling very tired (26%)
  • Lower hemoglobin levels (26%)

Other Side Effects

  • Vomiting
  • Not feeling hungry
  • Diarrhea
  • Constipation
  • Headache
  • Stomach pain
  • Hot flash

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Orserdu (elacestrant)

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Pros

Taken by mouth once a day

Targeted therapy, so it works in a more specific way than traditional chemotherapy

Don't need to take it with other anticancer medications

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Cons

Can raise cholesterol levels in the blood

Commonly causes nausea and muscle pain

Interacts with many medications, supplements, and food products (e.g. grapefruit juice)

pharmacist-tips

Pharmacist tips for Orserdu (elacestrant)

pharmacist

  • Orserdu (elacestrant) is available as 345 mg tablets and 86 mg tablets. You might need to take more than one 86 mg tablet to make your prescribed dose. Take the entire Orserdu (elacestrant) dose at once at around the same time every day.

    • If you forget to take your Orserdu (elacestrant) dose and it’s more than 6 hours after the usual time, skip that dose and take your next dose at the regular time.

      • Orserdu (elacestrant) can interact with other medications, supplements, and foods. For example, the herbal supplement St. John’s Wort can lower Orserdu (elacestrant) levels in the blood, which might make the medication not work as well. On the other hand, grapefruit juice can raise Orserdu (elacestrant) levels in the blood, which could put you at higher risk for side effects with the medication. It’s a good idea to share a complete list of medications, supplements, and herbals with your provider so they can make sure they’re safe to take with Orserdu (elacestrant).

        • If you’re able to become pregnant, or if you’re male and have a partner who’s able to become pregnant, continue using effective birth control while taking Orserdu (elacestrant) and for at least a week after the last dose. There's a risk that Orserdu (elacestrant) can cause harm in an unborn baby.

          faqs

          Frequently asked questions about Orserdu (elacestrant)

          How is Orserdu (elacestrant) different from fulvestrant (Faslodex)?
          Orserdu (elacestrant) and fulvestrant (Faslodex) are both elective estrogen receptor degraders (SERDs). Both can treat HR-positive, HER2-negative breast cancer. But, Orserdu (elacestrant) only treats breast cancer that has the ESR1 mutation. In addition, Orserdu (elacestrant) and fulvestrant (Faslodex) are used in slightly different ways and have different dosing strategies. For example, fulvestrant (Faslodex) is a first-choice treatment for breast cancer, while Orserdu (elacestrant) is only prescribed after the first-choice treatment no longer works well. Another example is that fulvestrant (Faslodex) is an injection usually given once a month, while Orserdu (elacestrant) is a pill that’s taken by mouth once a day. Talk with your healthcare team about which treatment might be best for you.
          How do I know if Orserdu (elacestrant) is right for me?
          Orserdu (elacestrant) is FDA-approved for people with advanced or metastatic breast cancer that’s ER-positive, HER2-negative, and ESR-1 mutated. It’s typically only prescribed after you’ve already tried a first-choice hormone treatment, but it’s no longer working well to treat the cancer. Before considering Orserdu (elacestrant), your healthcare team will check if your cancer has an ESR1 mutation with a blood test or biopsy. If so, then Orserdu (elacestrant) might be a treatment option for you.
          What should I do if I vomit after my Orserdu (elacestrant) dose?
          If you vomit after taking your Orserdu (elacestrant) dose, skip the dose and take your next dose at the regularly scheduled time. There’s no need to make up the dose or take a double dose. To prevent nausea and vomiting, try taking Orserdu (elacestrant) with food. If you often have a hard time keeping this medication down, let your provider know and they can recommend antinausea medications that are appropriate for you.
          What can I do to ease nausea while taking Orserdu (elacestrant)?
          Nausea is a common Orserdu (elacestrant) side effect. Make sure to take Orserdu (elacestrant) with food to help prevent nausea. If your provider prescribed you an antinausea medication, take it 30 minutes to an hour before your Orserdu (elacestrant) dose. Eating smaller meals more often, instead of larger meals 3 times a day can also help you prevent stomach upset. If the nausea makes it hard for you to get through the day, talk to your healthcare team. If your side effects are severe and aren’t well-controlled by medications, your provider might lower your Orserdu (elacestrant) dose, or have you take a break from the medication.
          What can I do to manage fatigue while taking Orserdu (elacestrant)?
          Orserdu (elacestrant) commonly causes fatigue. If you feel tired or weak, do your best to get enough sleep, eat a healthy diet, and stay hydrated. If you're up for it, doing some light exercise and movement can also help you feel less tired. It’s a good idea to keep track of your energy levels throughout the day, so you can schedule activities for times when you have more energy. If you're too tired to go through your typical daily activities, talk with your healthcare team. They might have other recommendations to help with your fatigue. They might also adjust your Orserdu (elacestrant) dose or have you take a break from the medication.
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          What are the risks and warnings for Orserdu (elacestrant)?

          Orserdu (elacestrant) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Higher cholesterol levels

          Orserdu (elacestrant) commonly raises triglyceride and cholesterol levels (lipids) in the blood. Before you start treatment with Orserdu (elacestrant), your provider will have you do a blood test to check on your cholesterol levels. They’ll continue checking your blood tests throughout treatment to make sure your lipid levels are in a safe range for you to continue the medication.

          risk-warning

          Harm to the unborn baby and breastfeeding child

          Let your provider know if you are pregnant or plan to become pregnant. Orserdu (elacestrant) is likely to harm unborn babies. If you’re able to become pregnant, your provider will have you do a pregnancy test before starting treatment. If you’re able to become pregnant, or you’re male and have a partner who’s able to become pregnant, continue using effective birth control while taking Orserdu (elacestrant) and for at least a week after the last dose. Since Orserdu (elacestrant) hasn’t been studied in people who are lactating, avoid breastfeeding while taking this medication and for 1 week after stopping.

          dosage

          Orserdu (elacestrant) dosage forms

          Typical dosing for Orserdu (elacestrant)

          The typical dose is 345 mg by mouth with food once a day.

          alternatives

          What are alternatives to Orserdu (elacestrant)?

          There are a number of medications that your doctor can prescribe in place of Orserdu (elacestrant). Compare a few possible alternatives below.
          Orserdu (elacestrant)
          Used for:
          View Prices
          Fulvestrant (Faslodex)
          Used for:

          • Hormone receptor (HR)-positive, advanced or metastatic breast cancer

          $234.50 Lowest GoodRx priceView Prices
          Anastrozole (Arimidex)
          Used for:

          • Early stage HR+ breast cancer in postmenopausal women

          • Advanced or metastatic HR+ breast cancer in postmenopausal women

          • Advanced breast cancer in postmenopausal women that's getting worse after treatment with tamoxifen

          $10.03 Lowest GoodRx priceView Prices
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          Orserdu (elacestrant) images

          Blue Oval Mh - Orserdu 345mg Tablet
          This medicine is Blue, Oval Tablet Imprinted With "Mh".Blue Oval Mh - Orserdu 345mg Tablet

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          References

          Best studies we found

          Alembic Pharmaceuticals Inc. (2023). Fulvestrant injection [package insert]. DailyMed.

          American Cancer Society. (2021). Breast cancer hormone receptor status.

          Burstein, H. J., et al. (2023). Testing for ESR1 mutations to guide therapy for hormone receptor–positive, human epidermal growth factor receptor 2–negative metastatic breast cancer: ASCO guideline rapid recommendation update. Journal of Clinical Oncology.

          View All References (3)

          Stemline Therapeutics, Inc. (2023). Orserdu- elacestrant tablet, film coated [package insert]. DailyMed.

          Stemline Therapeutics, Inc. (2023). Take Orserdu once a day, every day, from anywhere.

          Stemline Therapeutics, Inc. (2023). Understanding ESR1 mutations.

          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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