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Omeclamox-Pak Coupon - Omeclamox-Pak 10 day package

Omeclamox Pak

omeprazole / clarithromycin / amoxicillin
Used for Duodenal Ulcer
Used for Duodenal Ulcer

Omeclamox-Pak is a combination medication made up of omeprazole (a proton pump inhibitor), clarithromycin (a macrolide antibiotic), and amoxicillin (a penicillin antibiotic). These medications work together to treat H. pylori infections in adults and active or recent duodenal ulcers. The dose is taken twice daily, in the morning and evening, for 10 days. Side effects include diarrhea, changes in taste, and headache.

Note: Omeclamox-Pak has been discontinued and is no longer available.

Last reviewed on April 21, 2025
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What is Omeclamox-Pak?

What is Omeclamox-Pak used for?

How Omeclamox-Pak works

Omeclamox-Pak is a combination of three medications:

Are you looking for information on omeprazole (Prilosec), clarithromycin, or amoxicillin (Amoxil) alone instead?

Drug Facts

Common BrandsOmeclamox-Pak
Drug ClassPPI / Macrolide antibiotic / Penicillin antibiotic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
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Avg retail price
$905.46(save 43.88%)
GoodRx discount
$508.10
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What are the side effects of Omeclamox-Pak?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (14%)
  • Change in taste (10%)
  • Headache (7%)

Other Side Effects

  • Stomach pain
  • Nausea
  • Vomiting
  • Passing gas
  • Upper respiratory infection
  • Constipation
  • Dizziness
  • Rash
  • Lack of energy
  • Back pain
  • Cough

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reactions: trouble breathing, swelling of your face or tongue, swelling in your arms and legs, severe rash or hives, chest pain or tightness, racing heart, dizziness or fainting
  • Severe skin reaction: rash, blistering or peeling of skin, hives, fever, painful sores in your mouth or around your eyes
  • Infectious diarrhea (C. difficile-related diarrhea): rapid heart rate, fever, nausea, foul-smelling diarrhea, frequent bowel movements (even up to 15 times per day)
  • Kidney problems: fever, rash, tiredness, nausea, loss of appetite

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Lupus-like syndrome—joint pain, swelling, or stiffness, butterfly-shaped rash on the face, rashes that get worse in the sun, fever, unusual weakness or fatigue
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Severe diarrhea, fever
  • Severe or prolonged vomiting or diarrhea
  • Unusual vaginal discharge, itching, or odor

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Omeclamox-Pak

thumbs-up

Pros

Works well for treating H. pylori infection

Combines all three medications into a single pack

Only needs to be taken for 10 days

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Cons

Common side effects include diarrhea, changes in taste, and headache

Must take 4 pills at the same time for each dose

Can't be used if you have a penicillin allergy because it contains amoxicillin

pharmacist-tips

Pharmacist tips for Omeclamox-Pak

pharmacist
  • Take Omeclamox-Pak by mouth twice a day before a meal for 10 days. You can swallow the 4 pills one at a time if it makes it easier. Swallow the pills whole; never crush, chew, or open them because this can damage the medication.

    • If you have an ulcer when starting Omeclamox-Pak, you might need to take omeprazole 20 mg once a day for 18 more days. This helps heal the ulcer and ease symptoms.

      • Finish all 10 days of Omeclamox-Pak, even if you start feeling better. Stopping early or skipping doses can make the medication not work as well and possibly cause the infection to come back and be harder to treat.

        • If you get diarrhea while taking Omeclamox-Pak, drink plenty of fluids to stay hydrated. You can ask your care team if a probiotic might help. If recommended, take the probiotic at least 2 hours before or after your Omeclamox-Pak dose.

          • Call your prescriber if you develop severe diarrhea with stomach cramps, fever, or tiredness. These could be signs of infectious diarrhea, a rare but serious side effect of Omeclamox-Pak that can appear during or even months after treatment.

            • Watch for signs of a serious skin reaction while taking Omeclamox-Pak. If you notice a rash, sores in your mouth, or any other unusual skin changes, stop taking the medication right away and call your prescriber. These might be signs of an allergic reaction that needs quick medical attention.

              • Tell your care team about all of the medications and supplements you're taking or planning to take. Omeclamox-Pak interacts with many medications, and your care team can make sure everything is safe to take together.

                faqs

                Frequently asked questions about Omeclamox-Pak

                Is Omeclamox-Pak available?
                No, Omeclamox-Pak isn't available anymore. But the active ingredients — omeprazole, amoxicillin, and clarithromycin — are still available as separate medications that a healthcare professional can prescribe individually.
                How do you take Omeclamox-Pak?
                You take Omeclamox-Pak by mouth twice a day for 10 days, before a meal. Each dose includes 1 capsule of omeprazole (20 mg), 1 tablet of clarithromycin (500 mg), and 2 capsules of amoxicillin (500 mg each). All of these should be taken together once in the morning and once in the evening.
                Can you drink alcohol while you're taking Omeclamox-Pak?
                It's probably best to avoid drinking alcohol while you're taking Omeclamox-Pak. Alcohol can worsen stomach side effects like nausea, vomiting, and diarrhea. To stay safe, it's a good idea to wait until you've finished the full course before drinking alcohol. If you have questions, ask your prescriber or pharmacist.
                What are alternatives to Omeclamox-Pak?
                There are several treatment regimens that can be used instead of Omeclamox-Pak for treating H. pylori infection. Examples include lansoprazole / amoxicillin / clarithromycin combination and Voquezna Triple Pak (vonoprazan / amoxicillin/ clarithromycin). Since Omeclamox-Pak is no longer available, talk to your healthcare professional if you have questions about other treatment options.
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                What are the risks and warnings for Omeclamox-Pak?

                Omeclamox-Pak can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Harm to unborn baby

                Clarithromycin isn't recommended during pregnancy because it's not clear how safe it is. One study found no link between taking clarithromycin in the first trimester and major birth defects. But animal studies have shown harm to babies at higher doses than what's used in people. Talk to your prescriber about the risks and benefits of taking Omeclamox-Pak while pregnant. Ask them if there are any safer options available.

                risk-warning

                Severe skin reactions

                Omeclamox-Pak can cause rare but serious skin reactions like Stevens-Johnson syndrome (SJS), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, and toxic epidermal necrolysis (TEN). If you notice symptoms such as a rash, blistering, peeling skin, fever, or swelling, stop taking the medication right away and call your prescriber. These side effects are serious and might need immediate medical care.

                risk-warning

                Interaction with other medications

                Omeprazole, clarithromycin, and amoxicillin — the ingredients in Omeclamox-Pak — can interact with many common medications. These interactions can make some medications work less well or raise your risk of side effects. Examples include colchicine, amlodipine, warfarin, tacrolimus, digoxin, and certain statins.

                Tell your prescriber about all of the medications you're taking before starting Omeclamox-Pak. They can decide if you need any dose changes or if you should pause any medications during treatment. Don’t start any new medications without checking with your care team to make sure they’re safe to take together.

                risk-warning

                Worsening of myasthenia gravis

                Clarithromycin, one of the ingredients in Omeclamox-Pak, has been linked to worsening symptoms of myasthenia gravis. If you have a history of myasthenia gravis, talk to your prescriber before starting treatment. Your care team might need to monitor you closely for symptoms like muscle weakness, trouble swallowing, or difficulty breathing. Let them know right away if you notice any of these signs.

                risk-warning

                Infectious diarrhea

                Taking Omeclamox-Pak can raise your risk of getting an infection caused by a bacteria called Clostridioides difficile (C. difficile). C. difficile normally lives in your gut without causing problems. But taking antibiotics can make it grow out of control. This can lead to infectious diarrhea, which might be mild or life-threatening.

                C. difficile-related diarrhea is a medical emergency. Get help right away if you have symptoms like rapid heart rate, fever, nausea, foul-smelling diarrhea, and frequent bowel movements. You might have to get tested and treated for the infection.

                risk-warning

                Kidney problems

                A rare type of kidney inflammation called acute tubulointerstitial nephritis (TIN) has been reported in people taking proton pump inhibitors (PPIs) like omeprazole, one of the ingredients in Omeclamox-Pak. TIN can happen at any point during treatment. Symptoms can range from allergic reactions (like fever or rash) to more general signs of kidney problems, such as tiredness, nausea, or loss of appetite. Let your care team know if you notice any symptoms that could be related to kidney problems.

                risk-warning

                Lupus

                Some people who've taken proton pump inhibitors like omeprazole reported new or worsening symptoms related to lupus. Lupus is a condition that happens when your body’s immune system attacks itself. Contact your prescriber and stop taking Omeclamox-Pak if you notice a butterfly-like rash on your face, tiredness, joint pain or swelling, or sores on your skin. These can be symptoms of lupus.

                dosage

                Omeclamox-Pak dosage forms

                The average cost for 1 package of 10 day of Omeclamox-Pak is $508.10 with a free GoodRx coupon. This is 43.88% off the average retail price of $905.46.
                package
                Package
                DosageQuantityPrice as low asPrice per unit
                10 day1 package$508.10$508.10

                Typical dosing for Omeclamox-Pak

                Each card of Omeclamox-Pak contains the total daily dose of all three medications: 2 capsules of omeprazole 20 mg, 2 tablets of clarithromycin 500 mg, and 4 capsules of amoxicillin 500 mg.

                The typical dose is 1 capsule of omeprazole, 1 tablet of clarithromycin, and 2 capsules of amoxicillin taken together by mouth twice a day for 10 days.

                If you have an ulcer, you'll keep taking omeprazole 20 mg once a day for 18 more days.

                contraindications-icon

                Omeclamox-Pak contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Omeclamox-Pak will not be safe for you to take.
                alternatives

                What are alternatives to Omeclamox-Pak?

                There are a number of medications that your doctor can prescribe in place of Omeclamox-Pak. Compare a few possible alternatives below.
                Omeclamox-Pak
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                images

                Omeclamox-Pak images

                White Oblong 54 312 - Omeclamox-Pak
                This medicine is White, Oblong Package Imprinted With "54 312".White Oblong 54 312 - Omeclamox-Pak

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                References

                Best studies we found

                Andersson, N. W., et al. (2021). Association between use of macrolides in pregnancy and risk of major birth defects: Nationwide, register based cohort study. The British Medical Journal.

                Bhandari, J., et al. (2024). Tubulointerstitial nephritis. StatPearls.

                Chey, W., et al. (2024). ACG Clinical Guideline: Treatment of Helicobacter pylori infection. The American Journal of Gastroenterology.

                View All References (2)
                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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