Proton pump inhibitor and penicillin/macrolide antibiotic combinations are used to treat Helicobacter pylori infections. These combinations work by reducing stomach acid with a proton pump inhibitor, killing bacteria with a penicillin antibiotic, and stopping bacterial growth with a macrolide antibiotic. These medications are usually taken orally. Examples include omeprazole/amoxicillin/clarithromycin and lansoprazole/amoxicillin/clarithromycin. You can take these medications in pill form to help manage your condition effectively.