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Nilotinib
Specialty Drug

Tasigna

NILOTINIB is a medicine that targets proteins in cancer cells and stops the cells from growing. It is used to treat chronic myelogenous leukemia (CML). Compare kinase inhibitors.
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Nilotinib Side Effects

What should I watch for?

Visit your doctor for checks on your progress. You will need to have regular blood tests while on this medicine. Report any new symptoms promptly.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal or stomach pain or tenderness

black, tarry stools

bleeding gums

blood in the urine or stools

blurred vision

bone pain

clay colored stools

confusion

convulsions

cough or hoarseness

dark urine

decreased appetite

difficult or labored breathing

dry mouth

fainting

fever or chills

flushed, dry skin

fruit-like breath odor

headache

increased hunger

increased thirst

increased urination

irregular heartbeat, recurrent

loss of appetite

lower back or side pain

muscle aches, cramps, or pain

nausea and vomiting

no blood pressure

no breathing

no pulse

numbness, tingling, pain, or weakness in the hands or feet

painful or difficult urination

pale skin

pinpoint red spots on the skin

seizures

skin rash or itching

sore throat

stuffy or runny nose

sweating

swelling of the hands, ankles, feet, or lower legs

tightness in the chest

trembling

troubled breathing with exertion

ulcers, sores, or white spots in the mouth

unexplained weight loss

unusual bleeding or bruising

unusual tiredness or weakness

weakness and heaviness of the legs

yellow eyes or skin

Less common

Coma

decreased urine output

dizziness

fast heartbeat

muscle cramps in the hands, arms, feet, legs, or face

nervousness

numbness and tingling around the mouth, fingertips, or lips

rapid weight gain

tremor

Less common or rare

Bladder pain

bloody or cloudy urine

body aches or pain

constipation

cough producing mucus

depressed mood

difficult, burning, or painful urination

dry skin and hair

ear congestion

feeling cold

frequent urge to urinate

hair loss

loss of voice

muscle stiffness

pain or tenderness around the eyes and cheekbones

sensitivity to heat

slowed heartbeat

sneezing

swelling or puffiness of the face

tender, swollen glands in the neck

trouble sleeping

trouble swallowing

weight changes

white patches in the mouth or throat or on the tongue

white patches with diaper rash

Incidence not known

Pain or swelling of the treated skin

rapid, shallow breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

burning, itching, and pain in hairy areas

diarrhea

difficulty with moving

lack or loss of strength

muscle spasms

pain in the arms or legs

pain in the joints

pus at the root of the hair

swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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